Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

Anti-Inflammatory Effects of Sphingosine Kinase Modulation in Inflammatory Arthritis

(2014) W.-Q. Lai et al.   JOURNAL OF IMMUNOLOGY

Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate

(2011) Yugesh Kharel et al.   BIOCHEMICAL JOURNAL

Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells

(2011) Andrew J. Kennedy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel sphingosine kinase-1 inhibitors. Part 2

(2010) Yibin Xiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential regulation of sphingosine kinases 1 and 2 in lung injury

(2009) Raj Wadgaonkar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

When the Sphingosine Kinase 1/Sphingosine 1-Phosphate Pathway Meets Hypoxia Signaling: New Targets for Cancer Therapy

(2009) I. Ader et al.   CANCER RESEARCH

Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

(2009) D. Kapitonov et al.   CANCER RESEARCH

Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells

(2009) Andreas Billich et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

The vascular S1P gradient—Cellular sources and biological significance

(2008) T HLA   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

(2008) S. W. Paugh et al.   BLOOD

Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions

(2008) C. A. Oskeritzian et al.   BLOOD

Targeting SphK1 as a New Strategy against Cancer

(2008) Dai Shida et al.   CURRENT DRUG TARGETS

Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease

(2008) Yun-Ping Wu et al.   HUMAN MOLECULAR GENETICS

Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

(2008) Frank Niessen et al.   NATURE

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS