Acid sphingomyelinase determines melanoma progression and metastatic behaviour via the microphtalmia-associated transcription factor signalling pathway

Update on the melanoma staging system: The importance of sentinel node staging and primary tumor mitotic rate

(2014) Charles M. Balch et al.   JOURNAL OF SURGICAL ONCOLOGY

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2

(2013) Chonglin Luo et al.   CANCER LETTERS

Human Vγ2Vδ2 T cells limit breast cancer growth by modulating cell survival-, apoptosis-related molecules and microenvironment in tumors

(2013) Reeva Aggarwal et al.   INTERNATIONAL JOURNAL OF CANCER

Melanoma: New Insights and New Therapies

(2012) Vasiliki A. Nikolaou et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Melanoma molecular classes and prognosis in the postgenomic era

(2012) Elisa Tremante et al.   LANCET ONCOLOGY

Role of MicroRNA-182 in Posterior Uveal Melanoma: Regulation of Tumor Development through MITF, BCL2 and Cyclin D2

(2012) Dongsheng Yan et al.   PLoS One

Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer

(2011) Yixing Jiang et al.   CANCER BIOLOGY & THERAPY

β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas

(2011) William E. Damsky et al.   CANCER CELL

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase

(2011) Russell W. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

(2011) Satoru Yokoyama et al.   NATURE

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

(2011) Corine Bertolotto et al.   NATURE

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia and MITF control metastatic behaviour in mouse and human melanoma cells

(2011) Y Cheli et al.   ONCOGENE

Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny

(2011) Y Cheli et al.   ONCOGENE

Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF

(2011) E. Feige et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of c-Met with the Specific Small Molecule Tyrosine Kinase Inhibitor SU11274 Decreases Growth and Metastasis Formation of Experimental Human Melanoma

(2010) I. Kenessey et al.   CURRENT CANCER DRUG TARGETS

Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes

(2010) Bärbel Edelmann et al.   EMBO JOURNAL

Studies on the Role of Acid Sphingomyelinase and Ceramide in the Regulation of Tumor Necrosis Factor α (TNFα)-converting Enzyme Activity and TNFα Secretion in Macrophages

(2010) Krasimira A. Rozenova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syntaxin 4 Is Required for Acid Sphingomyelinase Activity and Apoptotic Function

(2010) Cristiana Perrotta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biological Roles of Acid and Neutral Sphingomyelinases and Their Regulation by Nitric Oxide

(2010) Cristiana Perrotta et al.   PHYSIOLOGY

PAX3 Expression in Normal Skin Melanocytes and Melanocytic Lesions (Naevi and Melanomas)

(2010) Sandra Medic et al.   PLoS One

Matrix metalloproteinase-1 expression induced by IL-1β requires acid sphingomyelinase

(2009) Jessica Bauer et al.   FEBS LETTERS

Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses

(2009) Eduardo J Villablanca et al.   NATURE MEDICINE

Frequent mutations in the MITF pathway in melanoma

(2009) Julia C. Cronin et al.   Pigment Cell & Melanoma Research

A multi-marker assay to distinguish malignant melanomas from benign nevi

(2009) M. Kashani-Sabet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of novel sense and antisense transcription at the TRPM2 locus in cancer

(2008) Ugo Orfanelli et al.   CELL RESEARCH

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases

(2008) Eric L. Smith et al.   FASEB JOURNAL

Caspase‐3 enhances lung metastasis and cell migration in a protease‐independent mechanism through the ERK pathway

(2008) Yu‐Jung Cheng et al.   INTERNATIONAL JOURNAL OF CANCER