Biofilms and Cyclic di-GMP (c-di-GMP) Signaling: Lessons fromPseudomonas aeruginosaand Other Bacteria

Novel Functions of (p)ppGpp and Cyclic di-GMP in Mycobacterial Physiology Revealed by Phenotype Microarray Analysis of Wild-Type and Isogenic Strains of Mycobacterium smegmatis

(2015) Kuldeepkumar Ramnaresh Gupta et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Application of Synthetic Peptide Arrays To Uncover Cyclic Di-GMP Binding Motifs

(2015) Juliane Düvel et al.   JOURNAL OF BACTERIOLOGY

Structural Basis of Functional Diversification of the HD-GYP Domain Revealed by the Pseudomonas aeruginosa PA4781 Protein, Which Displays an Unselective Bimetallic Binding Site

(2015) Serena Rinaldo et al.   JOURNAL OF BACTERIOLOGY

The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

(2015) Henrik Almblad et al.   JOURNAL OF BACTERIOLOGY

Diversity of Cyclic Di-GMP-Binding Proteins and Mechanisms

(2015) Shan-Ho Chou et al.   JOURNAL OF BACTERIOLOGY

Bacterial Rotary Export ATPases Are Allosterically Regulated by the Nucleotide Second Messenger Cyclic-di-GMP

(2015) Eleftheria Trampari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dimeric c-di-GMP Is Required for Post-translational Regulation of Alginate Production inPseudomonas aeruginosa

(2015) John C. Whitney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The REC domain mediated dimerization is critical for FleQ from Pseudomonas aeruginosa to function as a c-di-GMP receptor and flagella gene regulator

(2015) Tiantian Su et al.   JOURNAL OF STRUCTURAL BIOLOGY

Oligoribonuclease is a central feature of cyclic diguanylate signaling inPseudomonas aeruginosa

(2015) Dorit Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligoribonuclease is the primary degradative enzyme for pGpG inPseudomonas aeruginosathat is required for cyclic-di-GMP turnover

(2015) Mona W. Orr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Hierarchical Cascade of Second Messengers Regulates Pseudomonas aeruginosa Surface Behaviors

(2015) Yun Luo et al.   mBio

A Pterin-Dependent Signaling Pathway Regulates a Dual-Function Diguanylate Cyclase-Phosphodiesterase Controlling Surface Attachment in Agrobacterium tumefaciens

(2015) Nathan Feirer et al.   mBio

Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1

(2015) Shanshan Li et al.   Scientific Reports

Capture Compound Mass Spectrometry - A Powerful Tool to Identify Novel c-di-GMP Effector Proteins

(2015) Benoît-Joseph Laventie et al.   Jove-Journal of Visualized Experiments

Cyclic-di-GMP levels affectPseudomonas aeruginosafitness in the presence of imipenem

(2014) Gianlucca G. Nicastro et al.   ENVIRONMENTAL MICROBIOLOGY

The Diguanylate Cyclase SadC Is a Central Player in Gac/Rsm-Mediated Biofilm Formation in Pseudomonas aeruginosa

(2014) J. A. Moscoso et al.   JOURNAL OF BACTERIOLOGY

The Pseudomonas aeruginosa Diguanylate Cyclase GcbA, a Homolog of P. fluorescens GcbA, Promotes Initial Attachment to Surfaces, but Not Biofilm Formation, via Regulation of Motility

(2014) O. E. Petrova et al.   JOURNAL OF BACTERIOLOGY

Elevated levels of the second messenger c-di-GMP contribute to antimicrobial resistance ofPseudomonas aeruginosa

(2014) Kajal Gupta et al.   MOLECULAR MICROBIOLOGY

BrlR fromPseudomonas aeruginosais a c-di-GMP-responsive transcription factor

(2014) Jacob R. Chambers et al.   MOLECULAR MICROBIOLOGY

Diguanylate cyclase NicD-based signalling mechanism of nutrient-induced dispersion byPseudomonas aeruginosa

(2014) Ankita Basu Roy et al.   MOLECULAR MICROBIOLOGY

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

(2014) Rasmus Lykke Marvig et al.   NATURE GENETICS

Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles

(2014) Song Lin Chua et al.   Nature Communications

High-Throughput Screening Using the Differential Radial Capillary Action of Ligand Assay Identifies Ebselen As an Inhibitor of Diguanylate Cyclases

(2013) Ori J. Lieberman et al.   ACS Chemical Biology

Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria

(2013) Louise D. Christensen et al.   INFECTION AND IMMUNITY

NO-Induced Biofilm Dispersion in Pseudomonas aeruginosa Is Mediated by an MHYT Domain-Coupled Phosphodiesterase

(2013) Y. Li et al.   JOURNAL OF BACTERIOLOGY

Antimicrobial Tolerance of Pseudomonas aeruginosa Biofilms Is Activated during an Early Developmental Stage and Requires the Two-Component Hybrid SagS

(2013) K. Gupta et al.   JOURNAL OF BACTERIOLOGY

The MerR-Like Regulator BrlR Confers Biofilm Tolerance by Activating Multidrug Efflux Pumps in Pseudomonas aeruginosa Biofilms

(2013) J. Liao et al.   JOURNAL OF BACTERIOLOGY

Structure of the PilZ–FimXEAL–c-di-GMP Complex Responsible for the Regulation of Bacterial Type IV Pilus Biogenesis

(2013) Cristiane R. Guzzo et al.   JOURNAL OF MOLECULAR BIOLOGY

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

(2013) U. Romling et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

C-di-GMP Hydrolysis by Pseudomonas aeruginosa HD-GYP Phosphodiesterases: Analysis of the Reaction Mechanism and Novel Roles for pGpG

(2013) Valentina Stelitano et al.   PLoS One

Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ

(2013) C. Baraquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcellular Clustering of the Phosphorylated WspR Response Regulator Protein Stimulates Its Diguanylate Cyclase Activity

(2013) V. Huangyutitham et al.   mBio

c-di-GMP heterogeneity is generated by the chemotaxis machinery to regulate flagellar motility

(2013) Bridget R Kulasekara et al.   eLife

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis

(2012) Dimpy Kalia et al.   CHEMICAL SOCIETY REVIEWS

Structural Insights into the Regulatory Mechanism of the Response Regulator RocR from Pseudomonas aeruginosa in Cyclic Di-GMP Signaling

(2012) Ming Wei Chen et al.   JOURNAL OF BACTERIOLOGY

The Phosphodiesterase DipA (PA5017) Is Essential for Pseudomonas aeruginosa Biofilm Dispersion

(2012) A. B. Roy et al.   JOURNAL OF BACTERIOLOGY

The MerR-Like Transcriptional Regulator BrlR Contributes to Pseudomonas aeruginosa Biofilm Tolerance

(2012) Julie Liao et al.   JOURNAL OF BACTERIOLOGY

Structures of the PelD Cyclic Diguanylate Effector Involved in Pellicle Formation inPseudomonas aeruginosaPAO1

(2012) Zhi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production inPseudomonas aeruginosa

(2012) John C. Whitney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel capture compound for the identification and analysis of cyclic di-GMP binding proteins

(2012) Jutta Nesper et al.   Journal of Proteomics

The FleQ protein from Pseudomonas aeruginosa functions as both a repressor and an activator to control gene expression from the pel operon promoter in response to c-di-GMP

(2012) C. Baraquet et al.   NUCLEIC ACIDS RESEARCH

The YfiBNR Signal Transduction Mechanism Reveals Novel Targets for the Evolution of Persistent Pseudomonas aeruginosa in Cystic Fibrosis Airways

(2012) Jacob G. Malone et al.   PLoS Pathogens

Key two-component regulatory systems that control biofilm formation in Pseudomonas aeruginosa

(2011) Helga Mikkelsen et al.   ENVIRONMENTAL MICROBIOLOGY

The Pseudomonas aeruginosa sensor RetS switches Type III and Type VI secretion via c-di-GMP signalling

(2011) Joana A. Moscoso et al.   ENVIRONMENTAL MICROBIOLOGY

Systematic Analysis of Diguanylate Cyclases That Promote Biofilm Formation by Pseudomonas fluorescens Pf0-1

(2011) P. D. Newell et al.   JOURNAL OF BACTERIOLOGY

A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa

(2011) Juliane Düvel et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions

(2011) K. G. Roelofs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of Pseudomonas aeruginosa surface-associated group behaviors by individual amino acids through c-di-GMP signaling

(2011) Steve P. Bernier et al.   RESEARCH IN MICROBIOLOGY

Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

(2011) D. Nguyen et al.   SCIENCE

Modulation of Pseudomonas aeruginosa Biofilm Dispersal by a Cyclic-Di-GMP Phosphodiesterase with a Putative Hypoxia-Sensing Domain

(2010) S. An et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity

(2010) Alex Boehm et al.   CELL

Diversity of structure and function of response regulator output domains

(2010) Michael Y Galperin   CURRENT OPINION IN MICROBIOLOGY

Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain Phosphodiesterases

(2010) Anatoli Tchigvintsev et al.   JOURNAL OF MOLECULAR BIOLOGY

The c-di-GMP Binding Protein YcgR Controls Flagellar Motor Direction and Speed to Affect Chemotaxis by a “Backstop Brake” Mechanism

(2010) Koushik Paul et al.   MOLECULAR CELL

Comparative genomics of cyclic-di-GMP signalling in bacteria: post-translational regulation and catalytic activity

(2010) Aswin S.N. Seshasayee et al.   NUCLEIC ACIDS RESEARCH

Asymmetrical Distribution of the Second Messenger c-di-GMP upon Bacterial Cell Division

(2010) M. Christen et al.   SCIENCE

Cyclic-di-GMP Reaches Out into the Bacterial RNA World

(2010) R. Hengge   Science Signaling

Specific Control of Pseudomonas aeruginosa Surface-Associated Behaviors by Two c-di-GMP Diguanylate Cyclases

(2010) J. H. Merritt et al.   mBio

YfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa

(2010) Jacob G. Malone et al.   PLoS Pathogens

SiaA and SiaD are essential for inducing autoaggregation as a specific response to detergent stress inPseudomonas aeruginosa

(2009) Janosch Klebensberger et al.   ENVIRONMENTAL MICROBIOLOGY

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases

(2009) George S. Baillie   FEBS Journal

Bistable Expression of CsgD in Biofilm Development of Salmonella enterica Serovar Typhimurium

(2009) N. Grantcharova et al.   JOURNAL OF BACTERIOLOGY

Principles of c-di-GMP signalling in bacteria

(2009) Regine Hengge   NATURE REVIEWS MICROBIOLOGY

Connecting Quorum Sensing, c-di-GMP, Pel Polysaccharide, and Biofilm Formation in Pseudomonas aeruginosa through Tyrosine Phosphatase TpbA (PA3885)

(2009) Akihiro Ueda et al.   PLoS Pathogens

MucR, a Novel Membrane-Associated Regulator of Alginate Biosynthesis in Pseudomonas aeruginosa

(2008) I. D. Hay et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

HD-GYP domain proteins regulate biofilm formation and virulence inPseudomonas aeruginosa

(2008) Robert P. Ryan et al.   ENVIRONMENTAL MICROBIOLOGY

Catalytic Mechanism of Cyclic Di-GMP-Specific Phosphodiesterase: a Study of the EAL Domain-Containing RocR from Pseudomonas aeruginosa

(2008) F. Rao et al.   JOURNAL OF BACTERIOLOGY

Membrane topology and roles of Pseudomonas aeruginosa Alg8 and Alg44 in alginate polymerization

(2008) L. L. Oglesby et al.   MICROBIOLOGY-SGM

Identification of FleQ fromPseudomonas aeruginosaas a c-di-GMP-responsive transcription factor

(2008) Jason W. Hickman et al.   MOLECULAR MICROBIOLOGY

Phosphorylation-Independent Regulation of the Diguanylate Cyclase WspR

(2008) Nabanita De et al.   PLOS BIOLOGY