An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence

The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function

(2014) Kamakshi Sureka et al.   CELL

DhhP, a Cyclic di-AMP Phosphodiesterase of Borrelia burgdorferi, Is Essential for Cell Growth and Virulence

(2014) Meiping Ye et al.   INFECTION AND IMMUNITY

Two-Step Synthesis and Hydrolysis of Cyclic di-AMP in Mycobacterium tuberculosis

(2014) Kasi Manikandan et al.   PLoS One

Listeria monocytogenes MDR transporters are involved in LTA synthesis and triggering of innate immunity during infection

(2014) Keren Tadmor et al.   Frontiers in Cellular and Infection Microbiology

An HD-GYP Cyclic Di-Guanosine Monophosphate Phosphodiesterase with a Non-Heme Diiron–Carboxylate Active Site

(2013) Kyle D. Miner et al.   BIOCHEMISTRY

Cyclic Dinucleotides and the Innate Immune Response

(2013) Olga Danilchanka et al.   CELL

Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome

(2013) Ali A Abdul-Sater et al.   EMBO REPORTS

Two DHH Subfamily 1 Proteins in Streptococcus pneumoniae Possess Cyclic Di-AMP Phosphodiesterase Activity and Affect Bacterial Growth and Virulence

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-AMP Impairs Potassium Uptake Mediated by a Cyclic Di-AMP Binding Protein in Streptococcus pneumoniae

(2013) Y. Bai et al.   JOURNAL OF BACTERIOLOGY

Listeria monocytogenes Multidrug Resistance Transporters and Cyclic Di-AMP, Which Contribute to Type I Interferon Induction, Play a Role in Cell Wall Stress

(2013) M. Kaplan Zeevi et al.   JOURNAL OF BACTERIOLOGY

Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre

(2013) Dom Bellini et al.   MOLECULAR MICROBIOLOGY

Cyclic di-AMP: another second messenger enters the fray

(2013) Rebecca M. Corrigan et al.   NATURE REVIEWS MICROBIOLOGY

Systematic identification of conserved bacterial c-di-AMP receptor proteins

(2013) R. M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection

(2013) C. E. Witte et al.   mBio

Prokaryotic Diacylglycerol Kinase and Undecaprenol Kinase

(2012) Wade D. Van Horn et al.   Annual Review of Biophysics

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis

(2012) Dimpy Kalia et al.   CHEMICAL SOCIETY REVIEWS

Hyperinduction of Host Beta Interferon by a Listeria monocytogenes Strain Naturally Overexpressing the Multidrug Efflux Pump MdrT

(2012) Kierstyn T. Schwartz et al.   INFECTION AND IMMUNITY

Cyclic Di-AMP Homeostasis inBacillus subtilis

(2012) Felix M. P. Mehne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative transcriptomics of pathogenic and non-pathogenic Listeria species

(2012) Omri Wurtzel et al.   Molecular Systems Biology

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Unusual Heme-Binding PAS Domain from YybT Family Proteins

(2011) F. Rao et al.   JOURNAL OF BACTERIOLOGY

Analysis of the role of Bacillus subtilis σM in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis

(2011) Yun Luo et al.   MOLECULAR MICROBIOLOGY

Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions

(2011) K. G. Roelofs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae

(2011) G. Postic et al.   RNA

The Structure of an Unconventional HD-GYP Protein from Bdellovibrio Reveals the Roles of Conserved Residues in this Class of Cyclic-di-GMP Phosphodiesterases

(2011) A. L. Lovering et al.   mBio

c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

(2011) Rebecca M. Corrigan et al.   PLoS Pathogens

Listeria monocytogenes Triggers AIM2-Mediated Pyroptosis upon Infrequent Bacteriolysis in the Macrophage Cytosol

(2010) John-Demian Sauer et al.   Cell Host & Microbe

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Role of Escherichia coli YbeY, a highly conserved protein, in rRNA processing

(2010) Bryan W. Davies et al.   MOLECULAR MICROBIOLOGY

cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!

(2010) Mark Gomelsky   MOLECULAR MICROBIOLOGY

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

Role of GTPases in Bacterial Ribosome Assembly

(2009) Robert A. Britton   Annual Review of Microbiology

YybT Is a Signaling Protein That Contains a Cyclic Dinucleotide Phosphodiesterase Domain and a GGDEF Domain with ATPase Activity

(2009) Feng Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insight into the Mechanism of Substrate Specificity and Catalytic Activity of an HD-Domain Phosphohydrolase: The 5′-Deoxyribonucleotidase YfbR from Escherichia coli

(2008) Matthew D. Zimmerman et al.   JOURNAL OF MOLECULAR BIOLOGY

Great Times for Small Molecules: c-di-AMP, a Second Messenger Candidate in Bacteria and Archaea

(2008) U. Romling   Science Signaling