Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes

(2017) Guoxiang Xie et al.   Scientific Reports

Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy

(2016) Yoshihiro Komohara et al.   ADVANCED DRUG DELIVERY REVIEWS

Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis

(2016) Bo Kong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile Acid Analog Intercepts Liver Fibrosis

(2016) C. Daniel De Magalhaes Filho et al.   CELL

Association between serum bile acid profiles and gestational diabetes mellitus: A targeted metabolomics study

(2016) Jieying Gao et al.   CLINICA CHIMICA ACTA

Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis

(2016) Guoxiang Xie et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis

(2016) Anna Baghdasaryan et al.   JOURNAL OF HEPATOLOGY

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

(2016) Frederik Nevens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet–fed mice

(2016) Anuradha Rao et al.   Science Translational Medicine

Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment

(2016) Jordan E Axelrad et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Distinctly altered gut microbiota in the progression of liver disease

(2016) Guoxiang Xie et al.   Oncotarget

Tissue-specific actions of FXR in metabolism and cancer

(2015) Raffaella Maria Gadaleta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases

(2015) Bojan Stanimirov et al.   Hepatobiliary & Pancreatic Diseases International

New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond

(2015) Ulrich Beuers et al.   JOURNAL OF HEPATOLOGY

Two-step enzymatic synthesis of ursodeoxycholic acid with a new 7β-hydroxysteroid dehydrogenase from Ruminococcus torques

(2015) Ming-Min Zheng et al.   PROCESS BIOCHEMISTRY

Individual bile acids have differential effects on bile acid signaling in mice

(2015) Peizhen Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

TGR5 and Immunometabolism: Insights from Physiology and Pharmacology

(2015) Alessia Perino et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis

(2015) In Hye Jung et al.   NEOPLASIA

The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics

(2015) Jason M. Ridlon et al.   Acta Pharmaceutica Sinica B

Microbes, Microbiota, and Colon Cancer

(2014) Cynthia L. Sears et al.   Cell Host & Microbe

The Bacteroides fragilis Toxin Gene Is Prevalent in the Colon Mucosa of Colorectal Cancer Patients

(2014) Annemarie Boleij et al.   CLINICAL INFECTIOUS DISEASES

The cross talk between microbiota and the immune system: metabolites take center stage

(2014) Hagit Shapiro et al.   CURRENT OPINION IN IMMUNOLOGY

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation

(2014) Chiara Degirolamo et al.   HEPATOLOGY

Intestinal transport and metabolism of bile acids

(2014) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Exploitation of Cholane Scaffold for the Discovery of Potent and Selective Farnesoid X Receptor (FXR) and G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) Ligands

(2014) Carmen Festa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeted inhibition of the FGF19-FGFR4 pathway in hepatocellular carcinoma; translational safety considerations

(2014) Howard R. Mellor   LIVER INTERNATIONAL

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

Bacterial Bile Metabolising Gene Abundance in Crohn's, Ulcerative Colitis and Type 2 Diabetes Metagenomes

(2014) Alain Labbé et al.   PLoS One

Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?

(2014) Georgina L Hold   WORLD JOURNAL OF GASTROENTEROLOGY

Secondary bile acids: an underrecognized cause of colon cancer

(2014) Hana Ajouz et al.   World Journal of Surgical Oncology

Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency

(2014) Fabio Iannelli et al.   Nature Communications

Shaping macrophages function and innate immunity by bile acids: Mechanisms and implication in cholestatic liver diseases

(2014) Yvon Calmus et al.   Clinics and Research in Hepatology and Gastroenterology

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

(2014) Chiara Degirolamo et al.   Cell Reports

FXR silencing in human colon cancer by DNA methylation and KRAS signaling

(2013) Ann M. Bailey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition

(2013) Javier Vaquero et al.   BIOCHEMICAL PHARMACOLOGY

Inflammasome biology in fibrogenesis

(2013) Xinshou Ouyang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

(2013) Ning Ding et al.   CELL

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Nuclear Receptors as Drug Targets in Cholestatic Liver Diseases

(2013) Emina Halilbasic et al.   Clinics in Liver Disease

Tumour-associated macrophages and cancer

(2013) Jenny Cook et al.   CURRENT OPINION IN PHARMACOLOGY

Crosstalk between colon cancer cells and macrophages via inflammatory mediators and CD47 promotes tumour cell migration

(2013) Yuan Zhang et al.   EUROPEAN JOURNAL OF CANCER

TGR5 signalling inhibits the production of pro-inflammatory cytokines byin vitrodifferentiated inflammatory and intestinal macrophages in Crohn's disease

(2013) Kazuaki Yoneno et al.   IMMUNOLOGY

Farnesoid X Receptor Expression Is Decreased in Colonic Mucosa of Patients with Primary Sclerosing Cholangitis and Colitis-associated Neoplasia

(2013) Joana Torres et al.   INFLAMMATORY BOWEL DISEASES

Bile salts and their importance for drug absorption

(2013) René Holm et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The Bile Acid Receptor TGR5 Does Not Interact with β-Arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts

(2013) Dane D. Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile Acid Receptor Activation Modulates Hepatic Monocyte Activity and Improves Nonalcoholic Fatty Liver Disease

(2013) Rachel H. McMahan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages

(2013) Katrin Haselow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human Gut Microbiome and Risk for Colorectal Cancer

(2013) Jiyoung Ahn et al.   JNCI-Journal of the National Cancer Institute

Cocarcinogenic Effects of Intrahepatic Bile Acid Accumulation in Cholangiocarcinoma Development

(2013) Elisa Lozano et al.   MOLECULAR CANCER RESEARCH

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Commensal bacteria at the interface of host metabolism and the immune system

(2013) Jonathan R Brestoff et al.   NATURE IMMUNOLOGY

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

(2013) N. Iida et al.   SCIENCE

Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice

(2013) Guodong Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bile acids and liver carcinogenesis: TGR5 as a novel piece in the puzzle?

(2013) Noémie Péan et al.   Clinics and Research in Hepatology and Gastroenterology

Bile Acids Activate YAP to Promote Liver Carcinogenesis

(2013) Sayeepriyadarshini Anakk et al.   Cell Reports

Gut Microbial Flora, Prebiotics, and Probiotics in IBD: Their Current Usage and Utility

(2013) Franco Scaldaferri et al.   Biomed Research International

Expression of bile acid receptor TGR5 in gastric adenocarcinoma

(2012) Weibiao Cao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids

(2012) Lotta K. Stenman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia

(2012) Michael Quante et al.   CANCER CELL

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model

(2012) Pieter Van den Abbeele et al.   ISME Journal

FAO/WHO Guidelines on Probiotics

(2012) Lorenzo Morelli et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Bile acid transporters and regulatory nuclear receptors in the liver and beyond

(2012) Emina Halilbasic et al.   JOURNAL OF HEPATOLOGY

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

(2012) Juan C. García-Cañaveras et al.   JOURNAL OF LIPID RESEARCH

Urinary Metabolite Variation Is Associated with Pathological Progression of the Post-Hepatitis B Cirrhosis Patients

(2012) Xiaoning Wang et al.   JOURNAL OF PROTEOME RESEARCH

FXR signaling in the enterohepatic system

(2012) Tsutomu Matsubara et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Therapeutic Modulation of Microbiota-Host Metabolic Interactions

(2012) E. Holmes et al.   Science Translational Medicine

Bile acids in the colon, from healthy to cytotoxic molecules

(2012) Juan I. Barrasa et al.   TOXICOLOGY IN VITRO

Novel insight into mechanisms of cholestatic liver injury

(2012) Benjamin L Woolbright   WORLD JOURNAL OF GASTROENTEROLOGY

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

Carcinogenicity of deoxycholate, a secondary bile acid

(2011) Carol Bernstein et al.   ARCHIVES OF TOXICOLOGY

Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine

(2011) Raffaella M. Gadaleta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

PXR Prevents Cholesterol Gallstone Disease by Regulating Biosynthesis and Transport of Bile Salts

(2011) Jinhan He et al.   GASTROENTEROLOGY

A biliary HCO3−umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes

(2011) Simon Hohenester et al.   HEPATOLOGY

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

Expression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis

(2011) Sigurd Lax et al.   INTERNATIONAL JOURNAL OF CANCER

Type and location of tumor-infiltrating macrophages and lymphatic vessels predict survival of colorectal cancer patients

(2011) Annika Ålgars et al.   INTERNATIONAL JOURNAL OF CANCER

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

(2011) Tingting Wang et al.   ISME Journal

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

(2011) Hongwei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Activation of the Wnt/ -Catenin Pathway in Spontaneous Hepatocellular Carcinoma Observed in Farnesoid X Receptor Knockout Mice

(2011) A. Wolfe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

In Vitro Studies on the Inhibition of Colon Cancer by Butyrate and Polyphenolic Compounds

(2011) Pedro Goncalves et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

(2011) Rian M. Nijmeijer et al.   PLoS One

Nuclear Receptor Small Heterodimer Partner in Apoptosis Signaling and Liver Cancer

(2011) Yuxia Zhang et al.   Cancers

Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes

(2010) Giovanni Musso et al.   Annual Review of Medicine

Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease

(2010) Raffaella M. Gadaleta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Regulation of Bile Acid Synthesis by Fat-soluble Vitamins A and D

(2010) Daniel R. Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity

(2010) Gernot Zollner et al.   PHARMACOLOGY & THERAPEUTICS

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

(2010) J. R. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear receptors as therapeutic targets in cholestatic liver diseases

(2009) Gernot Zollner et al.   BRITISH JOURNAL OF PHARMACOLOGY

Low counts of Faecalibacterium prausnitzii in colitis microbiota

(2009) H. Sokol et al.   INFLAMMATORY BOWEL DISEASES

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

(2009) P. Vavassori et al.   JOURNAL OF IMMUNOLOGY

Bile acids: regulation of apoptosis by ursodeoxycholic acid

(2009) Joana D. Amaral et al.   JOURNAL OF LIPID RESEARCH

Bile acid transporters

(2009) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

(2009) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

Bile acids as endogenous etiologic agents in gastrointestinal cancer

(2009) Harris Bernstein et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Bile acids: Chemistry, physiology, and pathophysiology

(2009) Maria J Monte et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis

(2008) G. Y. Chen et al.   CANCER RESEARCH

Nuclear Bile Acid Receptor FXR Protects against Intestinal Tumorigenesis

(2008) S. Modica et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents

(2008) Charles Nicaise et al.   HEPATOLOGY

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY

Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development

(2008) R. R.M. Maran et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY

Gut microbiota: a potential new territory for drug targeting

(2008) Wei Jia et al.   NATURE REVIEWS DRUG DISCOVERY

Active Crohnʼs disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal flora

(2007) Alexander Swidsinski et al.   INFLAMMATORY BOWEL DISEASES

The Antiapoptotic Role of Pregnane X Receptor in Human Colon Cancer Cells

(2007) Jie Zhou et al.   MOLECULAR ENDOCRINOLOGY