Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis

Dysregulation of bile acid homeostasis in parenteral nutrition mouse model

(2016) Le Zhan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation

(2014) Chiara Degirolamo et al.   HEPATOLOGY

Mechanisms of STAT3 activation in the liver of FXR knockout mice

(2013) Guodong Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice

(2013) Guodong Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice

(2012) Prachi Borude et al.   HEPATOLOGY

Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

(2012) Bo Kong et al.   HEPATOLOGY

Loss of FXR Protects against Diet-Induced Obesity and Accelerates Liver Carcinogenesis inob/obMice

(2012) Yanqiao Zhang et al.   MOLECULAR ENDOCRINOLOGY

Cross-Regulation of Protein Stability by p53 and Nuclear Receptor SHP

(2012) Zhihong Yang et al.   PLoS One

Increased Activation of the Wnt/ -Catenin Pathway in Spontaneous Hepatocellular Carcinoma Observed in Farnesoid X Receptor Knockout Mice

(2011) A. Wolfe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition

(2010) Jiyoung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice

(2010) Youcai Zhang et al.   JOURNAL OF LIPID RESEARCH

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine

(2009) Ann M. Thomas et al.   HEPATOLOGY

Nuclear Bile Acid Receptor FXR Protects against Intestinal Tumorigenesis

(2008) S. Modica et al.   CANCER RESEARCH

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY

Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development

(2008) R. R.M. Maran et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS