Targeted inhibition of the FGF19-FGFR4 pathway in hepatocellular carcinoma; translational safety considerations

Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids

(2013) Justine H. Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma

(2012) Seiki Miura et al.   BMC CANCER

Hepatocellular Carcinoma with Obstructive Jaundice: Endoscopic and Percutaneous Biliary Drainage

(2012) Yasunori Minami et al.   DIGESTIVE DISEASES

Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma

(2012) Yuan Chen et al.   HEPATOLOGY

Acetyl-CoA Carboxylase 2−/−Mutant Mice are Protected against Fatty Liver under High-fat, High-carbohydrate Dietary andde NovoLipogenic Conditions

(2012) Lutfi Abu-Elheiga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models

(2012) Dorothy M. French et al.   PLoS One

Antibody-Mediated Inhibition of Fibroblast Growth Factor 19 Results in Increased Bile Acids Synthesis and Ileal Malabsorption of Bile Acids in Cynomolgus Monkeys

(2012) Rama Pai et al.   TOXICOLOGICAL SCIENCES

Fibroblast growth factors and their receptors in cancer

(2011) Jørgen Wesche et al.   BIOCHEMICAL JOURNAL

Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Plasma Metabolomics and Lipid Profiling

(2011) A. D. Patterson et al.   CANCER RESEARCH

The human gallbladder secretes fibroblast growth factor 19 into bile: Towards defining the role of fibroblast growth factor 19 in the enterobiliary tract

(2011) Serge J.L.B. Zweers et al.   HEPATOLOGY

Metabonomic Profiles Discriminate Hepatocellular Carcinoma from Liver Cirrhosis by Ultraperformance Liquid Chromatography–Mass Spectrometry

(2011) Baohong Wang et al.   JOURNAL OF PROTEOME RESEARCH

Serum and Urine Metabolite Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma*

(2011) Tianlu Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Liver Functional Reserve Estimation: State of the Art and Relevance to Local Treatments

(2010) Fotini Manizate et al.   ONCOLOGY

Managing bile acid diarrhoea

(2010) Julian R. F. Walters et al.   Therapeutic Advances in Gastroenterology

A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis

(2009) Julian R.F. Walters et al.   Clinical Gastroenterology and Hepatology

Role of the bile salt export pump, BSEP, in acquired forms of cholestasis

(2009) Bruno Stieger   DRUG METABOLISM REVIEWS

Hepatocellular carcinoma with bile duct tumor thrombi: Correlation of magnetic resonance imaging features to histopathologic manifestations

(2009) Qingyu Liu et al.   EUROPEAN JOURNAL OF RADIOLOGY

Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice

(2009) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

(2008) Frank G. Schaap et al.   HEPATOLOGY

Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention

(2008) Han Kiat Ho et al.   JOURNAL OF HEPATOLOGY