Intestinal transport and metabolism of bile acids

Ostα−/− mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity

(2014) Sadie G. Wheeler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Colonic inflammation and secondary bile acids in alcoholic cirrhosis

(2014) Genta Kakiyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Microbes, Microbiota, and Colon Cancer

(2014) Cynthia L. Sears et al.   Cell Host & Microbe

Probiotics and the BSH-related cholesterol lowering mechanism: a Jekyll and Hyde scenario

(2014) Sy-Bing Choi et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

The human microbiome and bile acid metabolism: dysbiosis, dysmetabolism, disease and intervention

(2014) Mitchell L Jones et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Role of the Microbiome in Energy Regulation and Metabolism

(2014) Max Nieuwdorp et al.   GASTROENTEROLOGY

Interactions Between the Intestinal Microbiome and Liver Diseases

(2014) Bernd Schnabl et al.   GASTROENTEROLOGY

Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype

(2014) Frédéric M. Vaz et al.   HEPATOLOGY

Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids

(2014) Lirui Wang et al.   JOURNAL OF HEPATOLOGY

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

(2014) Alan F. Hofmann et al.   JOURNAL OF LIPID RESEARCH

In Vivo Performance of a Novel Fluorinated Magnetic Resonance Imaging Agent for Functional Analysis of Bile Acid Transport

(2014) Diana Vivian et al.   MOLECULAR PHARMACEUTICS

Beyond intestinal soap—bile acids in metabolic control

(2014) Folkert Kuipers et al.   Nature Reviews Endocrinology

Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy

(2014) Julian R. F. Walters   Nature Reviews Gastroenterology & Hepatology

Bile salts act as effective protein-unfolding agents and instigators of disulfide stress in vivo

(2014) C. M. Cremers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bile acids are nutrient signaling hormones

(2014) Huiping Zhou et al.   STEROIDS

The gut microbiome, probiotics, bile acids axis, and human health

(2014) Mitchell Lawrence Jones et al.   TRENDS IN MICROBIOLOGY

PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis

(2014) Xueyan Zhou et al.   Nature Communications

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

(2014) Chiara Degirolamo et al.   Cell Reports

Advances in understanding of bile acid diarrhea

(2014) Michael Camilleri   Expert Review of Gastroenterology & Hepatology

Inhibition of ileal apical but not basolateral bile acid transport reduces atherosclerosis in apoE−/− mice

(2013) Tian Lan et al.   ATHEROSCLEROSIS

Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism

(2013) Youcai Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Transmembrane protein OSTA-1 shapes sensory cilia morphology via regulation of intracellular membrane trafficking in C. elegans

(2013) A. Olivier-Mason et al.   DEVELOPMENT

Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice

(2013) Samuele De Minicis et al.   HEPATOLOGY

Transport and biological activities of bile acids

(2013) Brittnee L. Zwicker et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

(2013) Genta Kakiyama et al.   JOURNAL OF HEPATOLOGY

Discovery of a Highly Potent, Nonabsorbable Apical Sodium-Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes

(2013) Yulin Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The heteromeric organic solute transporter, OSTα–OSTβ/SLC51: A transporter for steroid-derived molecules

(2013) Nazzareno Ballatori et al.   MOLECULAR ASPECTS OF MEDICINE

The solute carrier family 10 (SLC10): Beyond bile acid transport

(2013) Tatiana Claro da Silva et al.   MOLECULAR ASPECTS OF MEDICINE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Bile acid receptors as targets for drug development

(2013) Frank G. Schaap et al.   Nature Reviews Gastroenterology & Hepatology

Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters

(2013) M. Sawkat Anwer et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Effect of Dietary Prebiotics and Probiotics on Body Weight, Large Intestine Indices, and Fecal Bile Acid Profile in Wild Type and IL10−/− Mice

(2013) Shiu-Ming Kuo et al.   PLoS One

Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice

(2013) Xing Xian Yu et al.   PLoS One

Role of Glucuronidation for Hepatic Detoxification and Urinary Elimination of Toxic Bile Acids during Biliary Obstruction

(2013) Martin Perreault et al.   PLoS One

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

Microbial Biotransformations of Bile Acids as Detected by Electrospray Mass Spectrometry

(2013) Lee R. Hagey et al.   Advances in Nutrition

Bile Acids Activate YAP to Promote Liver Carcinogenesis

(2013) Sayeepriyadarshini Anakk et al.   Cell Reports

Bile resistance mechanisms in Lactobacillus and Bifidobacterium

(2013) Lorena Ruiz et al.   Frontiers in Microbiology

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

(2012) Matthew J. Potthoff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Relationship between bile salt hydrolase activity, changes in the internal pH and tolerance to bile acids in lactic acid bacteria

(2012) Ana Yanina Bustos et al.   BIOTECHNOLOGY LETTERS

Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans

(2012) T. Wu et al.   DIABETES OBESITY & METABOLISM

A Cholecystohepatic Shunt Pathway: Does the Gallbladder Protect the Liver?

(2012) James L. Boyer et al.   GASTROENTEROLOGY

Defects in Gallbladder Emptying and Bile Acid Homeostasis in Mice With Cystic Fibrosis Transmembrane Conductance Regulator Deficiencies

(2012) Dominique Debray et al.   GASTROENTEROLOGY

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

α5β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes

(2012) Holger Gohlke et al.   HEPATOLOGY

Defective bile salt biosynthesis and hydroxylation in mice with reduced cytochrome P450 activity

(2012) Cindy Kunne et al.   HEPATOLOGY

Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion

(2012) Shi-Ying Cai et al.   HEPATOLOGY

Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism

(2012) Tian Lan et al.   JOURNAL OF HEPATOLOGY

Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease

(2012) Derrick E. Fouts et al.   JOURNAL OF HEPATOLOGY

Bile acid transporters and regulatory nuclear receptors in the liver and beyond

(2012) Emina Halilbasic et al.   JOURNAL OF HEPATOLOGY

Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2)

(2012) Daniël A. Lionarons et al.   JOURNAL OF LIPID RESEARCH

Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXRα

(2012) Changming Fang et al.   JOURNAL OF LIPID RESEARCH

Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

(2012) Geoffrey Porez et al.   JOURNAL OF LIPID RESEARCH

Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in-vitro kinetic parameters for the prediction of clinically relevant drug-drug interactions

(2012) Anne Sophie Grandvuinet et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

Dysfunction of Organic Anion Transporting Polypeptide 1a1 Alters Intestinal Bacteria and Bile Acid Metabolism in Mice

(2012) Youcai Zhang et al.   PLoS One

Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure

(2012) Mitsuhiro Watanabe et al.   PLoS One

The Ileal Lipid Binding Protein Is Required for Efficient Absorption and Transport of Bile Acids in the Distal Portion of the Murine Small Intestine

(2012) Dana Praslickova et al.   PLoS One

Intestinal synthesis and secretion of bile salts as an adaptation to developmental biliary atresia in the sea lamprey

(2012) C.-Y. Yeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Therapeutic Modulation of Microbiota-Host Metabolic Interactions

(2012) E. Holmes et al.   Science Translational Medicine

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

(2012) Taoufiq Harach et al.   Scientific Reports

Discovering Novel Bile Protection Systems in Bifidobacterium breve UCC2003 through Functional Genomics

(2011) Lorena Ruiz et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1

(2011) Alex Odermatt et al.   BIOCHEMICAL JOURNAL

Efflux of bile acids in Lactobacillus reuteri is mediated by ATP

(2011) Ana Yanina Bustos et al.   BIOTECHNOLOGY LETTERS

Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion

(2011) HE Parker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

(2011) Elaine Studer et al.   HEPATOLOGY

Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice

(2011) Maite G. Fernández-Barrena et al.   JOURNAL OF HEPATOLOGY

Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC–MS/MS

(2011) Jiangeng Huang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Identification of Novel Nonsteroidal Compounds as Substrates or Inhibitors of hASBT

(2011) Vidula Kolhatkar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of Organic Anion-Transporting Polypeptide (Oatp) 1a1 and 1a4 Null Mice Reveals Altered Transport Function and Urinary Metabolomic Profiles

(2011) Lei Gong et al.   TOXICOLOGICAL SCIENCES

Functions of OATP1A and 1B transporters in vivo: insights from mouse models

(2011) Dilek Iusuf et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Bacterial degradation of bile salts

(2010) Bodo Philipp   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Getting the mOST from OST: Role of organic solute transporter, OSTα-OSTβ, in bile acid and steroid metabolism

(2010) Paul A. Dawson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Role of Breast Cancer Resistance Protein in the Adaptive Response to Cholestasis

(2010) A. Mennone et al.   DRUG METABOLISM AND DISPOSITION

Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice

(2010) Iván L. Csanaky et al.   HEPATOLOGY

Inhibiting the Initiation of Clostridium difficile Spore Germination using Analogs of Chenodeoxycholic Acid, a Bile Acid

(2010) J. A. Sorg et al.   JOURNAL OF BACTERIOLOGY

Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

(2010) Evita van de Steeg et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice

(2010) Youcai Zhang et al.   JOURNAL OF LIPID RESEARCH

Neurosteroid transport by the organic solute transporter OSTα-OSTβ

(2010) Fang Fang et al.   JOURNAL OF NEUROCHEMISTRY

Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice

(2010) Johanna H M Stroeve et al.   LABORATORY INVESTIGATION

The role of the gut microbiota in nonalcoholic fatty liver disease

(2010) Ahmed Abu-Shanab et al.   Nature Reviews Gastroenterology & Hepatology

Bile Acid-Induced Arrhythmia Is Mediated by Muscarinic M2 Receptors in Neonatal Rat Cardiomyocytes

(2010) Siti H. Sheikh Abdul Kadir et al.   PLoS One

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

(2010) J. R. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Transporter Proteins in Bile Tolerance of Lactobacillus acidophilus

(2009) E. A. Pfeiler et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Targeted Metabolomics Identifies Glucuronides of Dietary Phytoestrogens as a Major Class of MRP3 Substrates In Vivo

(2009) Koen van de Wetering et al.   GASTROENTEROLOGY

Bile acids: analysis in biological fluids and tissues

(2009) William J. Griffiths et al.   JOURNAL OF LIPID RESEARCH

Bile acid transporters

(2009) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Bile salts of vertebrates: structural variation and possible evolutionary significance

(2009) Alan F. Hofmann et al.   JOURNAL OF LIPID RESEARCH

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

Effect of bile salts on the DNA and membrane integrity of enteric bacteria

(2009) M. E. Merritt et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification

(2009) Yazen Alnouti   TOXICOLOGICAL SCIENCES

Ostα-Ostβ is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver

(2008) Nazzareno Ballatori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

(2008) A. F. Hofmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Vibrio cholerae RND Family Efflux Systems Are Required for Antimicrobial Resistance, Optimal Virulence Factor Production, and Colonization of the Infant Mouse Small Intestine

(2008) X. R. Bina et al.   INFECTION AND IMMUNITY

The ABC-Type Multidrug Resistance Transporter LmrCD Is Responsible for an Extrusion-Based Mechanism of Bile Acid Resistance in Lactococcus lactis

(2008) A. H. Zaidi et al.   JOURNAL OF BACTERIOLOGY

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

(2008) Hiroyuki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY

The X-Ray Structure of Zebrafish (Danio rerio) Ileal Bile Acid-Binding Protein Reveals the Presence of Binding Sites on the Surface of the Protein Molecule

(2008) Stefano Capaldi et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY

The organic solute transporter  - , Ost -Ost , is essential for intestinal bile acid transport and homeostasis

(2008) A. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

(2008) B. V. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bile Acids and the Membrane Bile Acid Receptor TGR5—Connecting Nutrition and Metabolism

(2008) Charles Thomas et al.   THYROID