Physiology and role of irisin in glucose homeostasis

Irisin exerts dual effects on browning and adipogenesis of human white adipocytes

(2016) Yuan Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Irisin levels in relation to metabolic and liver functions in Egyptian patients with metabolic syndrome

(2016) Fatma H. Rizk et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype

(2016) You-Cheol Hwang et al.   Cardiovascular Diabetology

Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice

(2016) Huikun Duan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Leptin administration in physiological or pharmacological doses does not alter circulating irisin levels in humans

(2016) A Gavrieli et al.   INTERNATIONAL JOURNAL OF OBESITY

Irisin Increased the Number and Improved the Function of Endothelial Progenitor Cells in Diabetes Mellitus Mice

(2016) Guangxu Zhu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

High Serum Irisin Level as an Independent Predictor of Diabetes Mellitus

(2016) Ji Hye Huh et al.   MEDICINE

Association between circulating irisin and insulin resistance in non-diabetic adults: A meta-analysis

(2016) Shanhu Qiu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism

(2016) Li Mo et al.   MOLECULAR ENDOCRINOLOGY

Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes

(2016) Shanshan Gao et al.   PLoS One

Association of irisin concentrations with the presence of diabetic nephropathy and retinopathy

(2016) Wenchao Hu et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling

(2016) Hong Tang et al.   EBioMedicine

Increased 24-hour ad libitum food intake is associated with lower plasma irisin concentrations the following morning in adult humans

(2015) Mathias Schlögl et al.   APPETITE

Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway

(2015) Fang Han et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice

(2015) Junyan Lu et al.   ATHEROSCLEROSIS

FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity

(2015) Xiao-Qing Xiong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes

(2015) Luc Rochette et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Central and Peripheral Irisin Differentially Regulate Blood Pressure

(2015) Weizhen Zhang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

(2015) Mark P. Jedrychowski et al.   Cell Metabolism

New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro

(2015) Min-Jung Park et al.   CELLULAR SIGNALLING

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

(2015) T.-Y. Liu et al.   CLINICAL SCIENCE

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice

(2015) Aaron R. Cox et al.   DIABETOLOGIA

Circulating irisin is lower in gestational diabetes mellitus

(2015) Liang Zhao et al.   ENDOCRINE JOURNAL

Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2

(2015) Nasser M. Al-Daghri et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues

(2015) Fatemeh Ahmadi Ghahrizjani et al.   GENE

Study on the Distribution and Elimination of the New Hormone Irisin In Vivo: New Discoveries Regarding Irisin

(2015) J. Lv et al.   HORMONE AND METABOLIC RESEARCH

Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues

(2015) J Dong et al.   INTERNATIONAL JOURNAL OF OBESITY

Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway

(2015) C Xin et al.   INTERNATIONAL JOURNAL OF OBESITY

SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise.

(2015) Joseph P. Tiano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SMAD3 Negatively Regulates Serum Irisin and Skeletal Muscle FNDC5 and Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) during Exercise

(2015) Joseph P. Tiano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Irisin in Response to Exercise in Humans With and Without Metabolic Syndrome

(2015) Joo Young Huh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Irisin and Its Relation to Insulin Resistance and Puberty in Obese Children: A Longitudinal Analysis

(2015) Thomas Reinehr et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Serum Irisin Levels Are Regulated by Acute Strenuous Exercise

(2015) Dennis Löffler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Elevated Circulating Levels of Irisin and the Effect of Metformin Treatment in Women With Polycystic Ovary Syndrome

(2015) Minyan Li et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Relationship between serum irisin levels and urinary albumin excretion in patients with type 2 diabetes

(2015) Hao-hua Wang et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses

(2015) Di Zhu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Irisin is more strongly predicted by muscle oxidative potential than adiposity in non-diabetic men

(2015) Claire Huth et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Irisin, a unique non-inflammatory myokine in stimulating skeletal muscle metabolism

(2015) Roger A. Vaughan et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid

(2015) A. E. Huerta et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Irisin: A true, circulating hormone

(2015) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

An update on the validity of irisin assays and the link between irisin and hepatic metabolism

(2015) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Resistance exercise induces a greater irisin response than endurance exercise

(2015) Yoshifumi Tsuchiya et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice

(2015) Tamiris Lima Rachid et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK

(2015) Hye Jeong Lee et al.   MOLECULAR ENDOCRINOLOGY

Irisin: A myokine with locomotor activity

(2015) Weizhen Zhang et al.   NEUROSCIENCE LETTERS

Irisin levels before and after physical activity among school-age children with different BMI: A direct relation with leptin

(2015) Berenice Palacios-González et al.   Obesity

Irisin, a newly discovered myokine, is a novel biomarker associated with physical activity in patients with chronic obstructive pulmonary disease

(2015) Naoki Ijiri et al.   RESPIROLOGY

Circulating irisin detection: Does it really work?

(2015) Fabian Sanchis-Gomar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Association of serum irisin and body composition with chronic kidney disease in obese Chinese adults: a cross-sectional study

(2015) Shuyu Yang et al.   BMC Nephrology

Irisin – a myth rather than an exercise-inducible myokine

(2015) Elke Albrecht et al.   Scientific Reports

Lower irisin level in patients with type 2 diabetes mellitus: A case-control study and meta-analysis

(2015) Chun Zhang et al.   Journal of Diabetes

Fibronectin type III domain containing 5 expression in skeletal muscle in chronic heart failure-relevance of inflammatory cytokines

(2015) Yae Matsuo et al.   Journal of Cachexia Sarcopenia and Muscle

Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training

(2015) Håvard Nygaard et al.   PLoS One

Circulating Irisin Levels Are Positively Associated with Metabolic Risk Factors in Sedentary Subjects

(2015) María Moreno et al.   PLoS One

Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pathway

(2015) Fei Wu et al.   PLoS One

High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects

(2014) G. Sesti et al.   ACTA DIABETOLOGICA

Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation

(2014) D.-J. Li et al.   Acta Physiologica

Serum Irisin Levels, Precocious Myocardial Infarction, and Healthy Exceptional Longevity

(2014) Enzo Emanuele et al.   AMERICAN JOURNAL OF MEDICINE

The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes

(2014) Milan K. Piya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

(2014) Viktoria Gusarova et al.   CELL

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Irisin: ‘fat’ or artefact

(2014) A.B. Crujeiras et al.   CLINICAL ENDOCRINOLOGY

Characterization of the metabolic effects of irisin on skeletal musclein vitro

(2014) R. A. Vaughan et al.   DIABETES OBESITY & METABOLISM

Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women

(2014) S. Ellefsen et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

FNDC5 could be regulated by leptin in adipose tissue

(2014) Carolina Gutierrez-Repiso et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Serum levels of the myokine irisin in relation to metabolic and renal function

(2014) Thomas Ebert et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Oxysterols induce mitochondrial impairment and hepatocellular toxicity in non-alcoholic fatty liver disease

(2014) Francesco Bellanti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inconsistency in Circulating Irisin Levels: What is Really Happening?

(2014) F. Sanchis-Gomar et al.   HORMONE AND METABOLIC RESEARCH

Irisin Is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise

(2014) Julia Brenmoehl et al.   International Journal of Biological Sciences

Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice

(2014) A Rodríguez et al.   INTERNATIONAL JOURNAL OF OBESITY

Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events

(2014) K N Aronis et al.   INTERNATIONAL JOURNAL OF OBESITY

Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

(2014) J Y Huh et al.   INTERNATIONAL JOURNAL OF OBESITY

Circulating Irisin in Healthy, Young Individuals: Day-Night Rhythm, Effects of Food Intake and Exercise, and Associations With Gender, Physical Activity, Diet, and Body Composition

(2014) Athanasios D. Anastasilakis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Exercise-Induced Irisin Secretion Is Independent of Age or Fitness Level and Increased Irisin May Directly Modulate Muscle Metabolism Through AMPK Activation

(2014) Joo Young Huh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Browning of white fat: does irisin play a role in humans?

(2014) Manuela Elsen et al.   JOURNAL OF ENDOCRINOLOGY

Irisin in response to acute and chronic whole-body vibration exercise in humans

(2014) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of a 1-year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children

(2014) Susann Blüher et al.   Obesity

Irisin as a muscle-derived hormone stimulating thermogenesis – A critical update

(2014) Tobias Hofmann et al.   PEPTIDES

Exercise-mimicking treatment fails to increase Fndc5 mRNA & irisin secretion in primary human myotubes

(2014) Timea Kurdiova et al.   PEPTIDES

A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues

(2014) Suleyman Aydin et al.   PEPTIDES

Association of Serum Irisin with Metabolic Syndrome in Obese Chinese Adults

(2014) Bing Yan et al.   PLoS One

Irisin Promotes Human Umbilical Vein Endothelial Cell Proliferation through the ERK Signaling Pathway and Partly Suppresses High Glucose-Induced Apoptosis

(2014) Haibo Song et al.   PLoS One

Association between Serum Irisin Levels and Non-Alcoholic Fatty Liver Disease in Health Screen Examinees

(2014) Eun Sung Choi et al.   PLoS One

Circulating levels of irisin in middle-aged first-degree relatives of type 2 diabetes mellitus — correlation with pancreatic β-cell function

(2014) Meili Yang et al.   Diabetology & Metabolic Syndrome

Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5

(2014) Jonathan M. Peterson et al.   PeerJ

Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women

(2013) Ana B. Crujeiras et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

(2013) Peng Yi et al.   CELL

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Irisin

(2013) Ulf Elbelt et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human  -Cell Replication in the Transplant Setting

(2013) Y. Jiao et al.   DIABETES

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

Serum irisin levels in new-onset type 2 diabetes

(2013) Yeon-Kyung Choi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle

(2013) Tizhong Shan et al.   FASEB JOURNAL

The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans

(2013) Frode Norheim et al.   FEBS Journal

Resistance Exercise Training does not Affect Plasma Irisin Levels of Hemodialysis Patients

(2013) C. Moraes et al.   HORMONE AND METABOLIC RESEARCH

Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine

(2013) A Besse-Patin et al.   INTERNATIONAL JOURNAL OF OBESITY

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

(2013) Maria A. Schumacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating Irisin in Relation to Insulin Resistance and the Metabolic Syndrome

(2013) Kyung Hee Park et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance

(2013) José María Moreno-Navarrete et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lower circulating irisin is associated with type 2 diabetes mellitus

(2013) Jian-Jun Liu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Relationship between circulating irisin, renal function and body composition in type 2 diabetes

(2013) Jian-Jun Liu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

(2013) Hui-Jie Zhang et al.   JOURNAL OF HEPATOLOGY

Are skeletal muscleFNDC5gene expression and irisin release regulated by exercise and related to health?

(2013) Satu Pekkala et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of obesity, diabetes and exercise onFndc5gene expression and irisin release in human skeletal muscle and adipose tissue:in vivoandin vitrostudies

(2013) Timea Kurdiova et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines

(2013) Hyun-Seuk Moon et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin in patients with nonalcoholic fatty liver disease

(2013) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients

(2013) Ana B. Crujeiras et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin in humans: recent advances and questions for future research

(2013) Pontus A. Boström et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin-immunoreactivity in neural and non-neural cells of the rodent

(2013) S.L. Dun et al.   NEUROSCIENCE

FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine

(2013) Arturo Roca-Rivada et al.   PLoS One

Decrease in Irisin in Patients with Chronic Kidney Disease

(2013) Ming-Shien Wen et al.   PLoS One

Evidence against a Beneficial Effect of Irisin in Humans

(2013) Silja Raschke et al.   PLoS One

The p38–PGC-1α–irisin–betatrophin axis

(2013) Fabian Sanchis-Gomar et al.   Adipocyte

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells

(2012) M.-S. Hashemi et al.   NEUROSCIENCE

Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index

(2012) Andreas Stengel et al.   PEPTIDES

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects

(2010) Eun Hee Koh et al.   AMERICAN JOURNAL OF MEDICINE

Measurement of human growth hormone by immunoassays: Current status, unsolved problems and clinical consequences

(2009) Martin Bidlingmaier et al.   GROWTH HORMONE & IGF RESEARCH