Effects of obesity, diabetes and exercise onFndc5gene expression and irisin release in human skeletal muscle and adipose tissue:in vivoandin vitrostudies

Banting Lecture 2012: Regulation of Adipogenesis: Toward New Therapeutics for Metabolic Disease

(2013) B. M. Spiegelman   DIABETES

Serum irisin levels in new-onset type 2 diabetes

(2013) Yeon-Kyung Choi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance

(2013) José María Moreno-Navarrete et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lower circulating irisin is associated with type 2 diabetes mellitus

(2013) Jian-Jun Liu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass

(2013) Andrew G. Swick et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin: A renaissance in metabolism?

(2013) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin-immunoreactivity in neural and non-neural cells of the rodent

(2013) S.L. Dun et al.   NEUROSCIENCE

Interrelation of31P-MRS metabolism measurements in resting and exercised quadriceps muscle of overweight-to-obese sedentary individuals

(2013) Ladislav Valkovič et al.   NMR IN BIOMEDICINE

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity

(2013) Harald Staiger et al.   PLoS One

FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine

(2013) Arturo Roca-Rivada et al.   PLoS One

Expression of the Irisin Precursor FNDC5 in Skeletal Muscle Correlates With Aerobic Exercise Performance in Patients With Heart Failure

(2012) Stewart H. Lecker et al.   Circulation-Heart Failure

Altered Response of Skeletal Muscle to IL-6 in Type 2 Diabetic Patients

(2012) L. Q. Jiang et al.   DIABETES

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

(2012) Marica Bordicchia et al.   JOURNAL OF CLINICAL INVESTIGATION

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Is irisin a human exercise gene?

(2012) James A. Timmons et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index

(2012) Andreas Stengel et al.   PEPTIDES

Age effect on myocellular remodeling: Response to exercise and nutrition in humans

(2011) Brian A. Irving et al.   AGEING RESEARCH REVIEWS

Bimodal Effect on Pancreatic  -Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle

(2011) K. Bouzakri et al.   DIABETES

Remodeling Lipid Metabolism and Improving Insulin Responsiveness in Human Primary Myotubes

(2011) Lauren M. Sparks et al.   PLoS One

Adipokine Protein Expression Pattern in Growth Hormone Deficiency Predisposes to the Increased Fat Cell Size and the Whole Body Metabolic Derangements

(2008) Jozef Ukropec et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

(2008) Bente K. Pedersen et al.   PHYSIOLOGICAL REVIEWS