标题
Physiology and role of irisin in glucose homeostasis
作者
关键词
-
出版物
Nature Reviews Endocrinology
Volume 13, Issue 6, Pages 324-337
出版商
Springer Nature
发表日期
2017-02-17
DOI
10.1038/nrendo.2016.221
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Irisin exerts dual effects on browning and adipogenesis of human white adipocytes
- (2016) Yuan Zhang et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Irisin levels in relation to metabolic and liver functions in Egyptian patients with metabolic syndrome
- (2016) Fatma H. Rizk et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype
- (2016) You-Cheol Hwang et al. Cardiovascular Diabetology
- Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice
- (2016) Huikun Duan et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Leptin administration in physiological or pharmacological doses does not alter circulating irisin levels in humans
- (2016) A Gavrieli et al. INTERNATIONAL JOURNAL OF OBESITY
- Irisin Increased the Number and Improved the Function of Endothelial Progenitor Cells in Diabetes Mellitus Mice
- (2016) Guangxu Zhu et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- High Serum Irisin Level as an Independent Predictor of Diabetes Mellitus
- (2016) Ji Hye Huh et al. MEDICINE
- Association between circulating irisin and insulin resistance in non-diabetic adults: A meta-analysis
- (2016) Shanhu Qiu et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism
- (2016) Li Mo et al. MOLECULAR ENDOCRINOLOGY
- Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes
- (2016) Shanshan Gao et al. PLoS One
- Association of irisin concentrations with the presence of diabetic nephropathy and retinopathy
- (2016) Wenchao Hu et al. ANNALS OF CLINICAL BIOCHEMISTRY
- Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling
- (2016) Hong Tang et al. EBioMedicine
- Increased 24-hour ad libitum food intake is associated with lower plasma irisin concentrations the following morning in adult humans
- (2015) Mathias Schlögl et al. APPETITE
- Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway
- (2015) Fang Han et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice
- (2015) Junyan Lu et al. ATHEROSCLEROSIS
- FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity
- (2015) Xiao-Qing Xiong et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes
- (2015) Luc Rochette et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Central and Peripheral Irisin Differentially Regulate Blood Pressure
- (2015) Weizhen Zhang et al. CARDIOVASCULAR DRUGS AND THERAPY
- Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry
- (2015) Mark P. Jedrychowski et al. Cell Metabolism
- New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro
- (2015) Min-Jung Park et al. CELLULAR SIGNALLING
- Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes
- (2015) T.-Y. Liu et al. CLINICAL SCIENCE
- Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice
- (2015) Aaron R. Cox et al. DIABETOLOGIA
- Circulating irisin is lower in gestational diabetes mellitus
- (2015) Liang Zhao et al. ENDOCRINE JOURNAL
- Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2
- (2015) Nasser M. Al-Daghri et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues
- (2015) Fatemeh Ahmadi Ghahrizjani et al. GENE
- Study on the Distribution and Elimination of the New Hormone Irisin In Vivo: New Discoveries Regarding Irisin
- (2015) J. Lv et al. HORMONE AND METABOLIC RESEARCH
- Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues
- (2015) J Dong et al. INTERNATIONAL JOURNAL OF OBESITY
- Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway
- (2015) C Xin et al. INTERNATIONAL JOURNAL OF OBESITY
- SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise.
- (2015) Joseph P. Tiano et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SMAD3 Negatively Regulates Serum Irisin and Skeletal Muscle FNDC5 and Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) during Exercise
- (2015) Joseph P. Tiano et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Irisin in Response to Exercise in Humans With and Without Metabolic Syndrome
- (2015) Joo Young Huh et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Irisin and Its Relation to Insulin Resistance and Puberty in Obese Children: A Longitudinal Analysis
- (2015) Thomas Reinehr et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Serum Irisin Levels Are Regulated by Acute Strenuous Exercise
- (2015) Dennis Löffler et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Elevated Circulating Levels of Irisin and the Effect of Metformin Treatment in Women With Polycystic Ovary Syndrome
- (2015) Minyan Li et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Relationship between serum irisin levels and urinary albumin excretion in patients with type 2 diabetes
- (2015) Hao-hua Wang et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses
- (2015) Di Zhu et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Irisin is more strongly predicted by muscle oxidative potential than adiposity in non-diabetic men
- (2015) Claire Huth et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Irisin, a unique non-inflammatory myokine in stimulating skeletal muscle metabolism
- (2015) Roger A. Vaughan et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid
- (2015) A. E. Huerta et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Irisin: A true, circulating hormone
- (2015) Stergios A. Polyzos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- An update on the validity of irisin assays and the link between irisin and hepatic metabolism
- (2015) Stergios A. Polyzos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Resistance exercise induces a greater irisin response than endurance exercise
- (2015) Yoshifumi Tsuchiya et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice
- (2015) Tamiris Lima Rachid et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK
- (2015) Hye Jeong Lee et al. MOLECULAR ENDOCRINOLOGY
- Irisin: A myokine with locomotor activity
- (2015) Weizhen Zhang et al. NEUROSCIENCE LETTERS
- Irisin levels before and after physical activity among school-age children with different BMI: A direct relation with leptin
- (2015) Berenice Palacios-González et al. Obesity
- Irisin, a newly discovered myokine, is a novel biomarker associated with physical activity in patients with chronic obstructive pulmonary disease
- (2015) Naoki Ijiri et al. RESPIROLOGY
- Circulating irisin detection: Does it really work?
- (2015) Fabian Sanchis-Gomar et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Association of serum irisin and body composition with chronic kidney disease in obese Chinese adults: a cross-sectional study
- (2015) Shuyu Yang et al. BMC Nephrology
- Irisin – a myth rather than an exercise-inducible myokine
- (2015) Elke Albrecht et al. Scientific Reports
- Lower irisin level in patients with type 2 diabetes mellitus: A case-control study and meta-analysis
- (2015) Chun Zhang et al. Journal of Diabetes
- Fibronectin type III domain containing 5 expression in skeletal muscle in chronic heart failure-relevance of inflammatory cytokines
- (2015) Yae Matsuo et al. Journal of Cachexia Sarcopenia and Muscle
- Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training
- (2015) Håvard Nygaard et al. PLoS One
- Circulating Irisin Levels Are Positively Associated with Metabolic Risk Factors in Sedentary Subjects
- (2015) María Moreno et al. PLoS One
- Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pathway
- (2015) Fei Wu et al. PLoS One
- High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects
- (2014) G. Sesti et al. ACTA DIABETOLOGICA
- Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation
- (2014) D.-J. Li et al. Acta Physiologica
- Serum Irisin Levels, Precocious Myocardial Infarction, and Healthy Exceptional Longevity
- (2014) Enzo Emanuele et al. AMERICAN JOURNAL OF MEDICINE
- The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes
- (2014) Milan K. Piya et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion
- (2014) Viktoria Gusarova et al. CELL
- Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans
- (2014) Paul Lee et al. Cell Metabolism
- Irisin: ‘fat’ or artefact
- (2014) A.B. Crujeiras et al. CLINICAL ENDOCRINOLOGY
- Characterization of the metabolic effects of irisin on skeletal musclein vitro
- (2014) R. A. Vaughan et al. DIABETES OBESITY & METABOLISM
- Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women
- (2014) S. Ellefsen et al. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
- FNDC5 could be regulated by leptin in adipose tissue
- (2014) Carolina Gutierrez-Repiso et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Serum levels of the myokine irisin in relation to metabolic and renal function
- (2014) Thomas Ebert et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Oxysterols induce mitochondrial impairment and hepatocellular toxicity in non-alcoholic fatty liver disease
- (2014) Francesco Bellanti et al. FREE RADICAL BIOLOGY AND MEDICINE
- Inconsistency in Circulating Irisin Levels: What is Really Happening?
- (2014) F. Sanchis-Gomar et al. HORMONE AND METABOLIC RESEARCH
- Irisin Is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise
- (2014) Julia Brenmoehl et al. International Journal of Biological Sciences
- Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice
- (2014) A Rodríguez et al. INTERNATIONAL JOURNAL OF OBESITY
- Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events
- (2014) K N Aronis et al. INTERNATIONAL JOURNAL OF OBESITY
- Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans
- (2014) J Y Huh et al. INTERNATIONAL JOURNAL OF OBESITY
- Circulating Irisin in Healthy, Young Individuals: Day-Night Rhythm, Effects of Food Intake and Exercise, and Associations With Gender, Physical Activity, Diet, and Body Composition
- (2014) Athanasios D. Anastasilakis et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Exercise-Induced Irisin Secretion Is Independent of Age or Fitness Level and Increased Irisin May Directly Modulate Muscle Metabolism Through AMPK Activation
- (2014) Joo Young Huh et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Browning of white fat: does irisin play a role in humans?
- (2014) Manuela Elsen et al. JOURNAL OF ENDOCRINOLOGY
- Irisin in response to acute and chronic whole-body vibration exercise in humans
- (2014) Joo Young Huh et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Effects of a 1-year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children
- (2014) Susann Blüher et al. Obesity
- Irisin as a muscle-derived hormone stimulating thermogenesis – A critical update
- (2014) Tobias Hofmann et al. PEPTIDES
- Exercise-mimicking treatment fails to increase Fndc5 mRNA & irisin secretion in primary human myotubes
- (2014) Timea Kurdiova et al. PEPTIDES
- A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues
- (2014) Suleyman Aydin et al. PEPTIDES
- Association of Serum Irisin with Metabolic Syndrome in Obese Chinese Adults
- (2014) Bing Yan et al. PLoS One
- Irisin Promotes Human Umbilical Vein Endothelial Cell Proliferation through the ERK Signaling Pathway and Partly Suppresses High Glucose-Induced Apoptosis
- (2014) Haibo Song et al. PLoS One
- Association between Serum Irisin Levels and Non-Alcoholic Fatty Liver Disease in Health Screen Examinees
- (2014) Eun Sung Choi et al. PLoS One
- Circulating levels of irisin in middle-aged first-degree relatives of type 2 diabetes mellitus — correlation with pancreatic β-cell function
- (2014) Meili Yang et al. Diabetology & Metabolic Syndrome
- Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5
- (2014) Jonathan M. Peterson et al. PeerJ
- Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women
- (2013) Ana B. Crujeiras et al. AMERICAN JOURNAL OF HUMAN BIOLOGY
- RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation
- (2013) Peng Yi et al. CELL
- Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway
- (2013) Christiane D. Wrann et al. Cell Metabolism
- Irisin
- (2013) Ulf Elbelt et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human -Cell Replication in the Transplant Setting
- (2013) Y. Jiao et al. DIABETES
- Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling
- (2013) Y. Zhang et al. DIABETES
- Serum irisin levels in new-onset type 2 diabetes
- (2013) Yeon-Kyung Choi et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle
- (2013) Tizhong Shan et al. FASEB JOURNAL
- The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans
- (2013) Frode Norheim et al. FEBS Journal
- Resistance Exercise Training does not Affect Plasma Irisin Levels of Hemodialysis Patients
- (2013) C. Moraes et al. HORMONE AND METABOLIC RESEARCH
- Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine
- (2013) A Besse-Patin et al. INTERNATIONAL JOURNAL OF OBESITY
- The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer
- (2013) Maria A. Schumacher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Circulating Irisin in Relation to Insulin Resistance and the Metabolic Syndrome
- (2013) Kyung Hee Park et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance
- (2013) José María Moreno-Navarrete et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Lower circulating irisin is associated with type 2 diabetes mellitus
- (2013) Jian-Jun Liu et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Relationship between circulating irisin, renal function and body composition in type 2 diabetes
- (2013) Jian-Jun Liu et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Irisin is inversely associated with intrahepatic triglyceride contents in obese adults
- (2013) Hui-Jie Zhang et al. JOURNAL OF HEPATOLOGY
- Are skeletal muscleFNDC5gene expression and irisin release regulated by exercise and related to health?
- (2013) Satu Pekkala et al. JOURNAL OF PHYSIOLOGY-LONDON
- Effects of obesity, diabetes and exercise onFndc5gene expression and irisin release in human skeletal muscle and adipose tissue:in vivoandin vitrostudies
- (2013) Timea Kurdiova et al. JOURNAL OF PHYSIOLOGY-LONDON
- Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines
- (2013) Hyun-Seuk Moon et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Irisin in patients with nonalcoholic fatty liver disease
- (2013) Stergios A. Polyzos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
- (2013) Ana B. Crujeiras et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Irisin in humans: recent advances and questions for future research
- (2013) Pontus A. Boström et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Irisin-immunoreactivity in neural and non-neural cells of the rodent
- (2013) S.L. Dun et al. NEUROSCIENCE
- FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine
- (2013) Arturo Roca-Rivada et al. PLoS One
- Decrease in Irisin in Patients with Chronic Kidney Disease
- (2013) Ming-Shien Wen et al. PLoS One
- Evidence against a Beneficial Effect of Irisin in Humans
- (2013) Silja Raschke et al. PLoS One
- The p38–PGC-1α–irisin–betatrophin axis
- (2013) Fabian Sanchis-Gomar et al. Adipocyte
- FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
- (2012) Joo Young Huh et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
- (2012) Pontus Boström et al. NATURE
- Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells
- (2012) M.-S. Hashemi et al. NEUROSCIENCE
- Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index
- (2012) Andreas Stengel et al. PEPTIDES
- Inflammatory Mechanisms in Obesity
- (2011) Margaret F. Gregor et al. Annual Review of Immunology
- Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling
- (2011) Hariom Yadav et al. Cell Metabolism
- Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin
- (2011) Janne Orava et al. Cell Metabolism
- Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects
- (2010) Eun Hee Koh et al. AMERICAN JOURNAL OF MEDICINE
- Measurement of human growth hormone by immunoassays: Current status, unsolved problems and clinical consequences
- (2009) Martin Bidlingmaier et al. GROWTH HORMONE & IGF RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now