Dysregulation of the angiopoietin–Tie-2 axis in sepsis and ARDS

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ligand-independent Tie2 Dimers Mediate Kinase Activity Stimulated by High Dose Angiopoietin-1

(2013) Daishi Yamakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma angiopoietin-2 in clinical acute lung injury

(2012) Carolyn S. Calfee et al.   CRITICAL CARE MEDICINE

Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*

(2012) Sascha David et al.   CRITICAL CARE MEDICINE

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

(2012) Moritz Felcht et al.   JOURNAL OF CLINICAL INVESTIGATION

Pleiotropic effects of angiopoietin-2 deficiency do not protect mice against endotoxin-induced acute kidney injury

(2012) Neng F. Kurniati et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Elevated Plasma Angiopoietin-2 Levels and Primary Graft Dysfunction after Lung Transplantation

(2012) Joshua M. Diamond et al.   PLoS One

Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax

(2012) C. C. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality

(2011) Sascha David et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ANGPT2Genetic Variant Is Associated with Trauma-associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio

(2011) Nuala J. Meyer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Systemic Dysregulation of Angiopoietin-1 and -2 in Streptococcal Toxic Shock Syndrome

(2011) A. V. Page et al.   CLINICAL INFECTIOUS DISEASES

Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis*

(2011) Daniel R. Ricciuto et al.   CRITICAL CARE MEDICINE

Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of β-Catenin

(2011) Jianghui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

(2011) Marie Jeansson et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiopoietin-2, a Regulator of Vascular Permeability in Inflammation, Is Associated With Persistent Organ Failure in Patients With Acute Pancreatitis From the United States and Germany

(2010) David C Whitcomb et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Angiopoietin-2-Driven Vascular Remodeling in Airway Inflammation

(2010) Sebastien P. Tabruyn et al.   AMERICAN JOURNAL OF PATHOLOGY

Imbalances in serum angiopoietin concentrations are early predictors of septic shock development in patients with post chemotherapy febrile neutropenia

(2010) Brunna E Alves et al.   BMC INFECTIOUS DISEASES

Tie1-Tie2 Interactions Mediate Functional Differences between Angiopoietin Ligands

(2010) Tom C.M. Seegar et al.   MOLECULAR CELL

Angiopoietin-2, Marker and Mediator of Endothelial Activation With Prognostic Significance Early After Trauma?

(2009) Michael T. Ganter et al.   ANNALS OF SURGERY

Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality

(2009) Melanie van der Heijden et al.   INTENSIVE CARE MEDICINE

Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome

(2009) Philipp Kümpers et al.   INTENSIVE CARE MEDICINE

Genetic variants in the angiopoietin-2 gene are associated with increased risk of ARDS

(2009) Li Su et al.   INTENSIVE CARE MEDICINE

VE-PTP controls blood vessel development by balancing Tie-2 activity

(2009) Mark Winderlich et al.   JOURNAL OF CELL BIOLOGY

Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium

(2009) H. T. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Serum Angiopoietin-1 and -2 Levels Discriminate Cerebral Malaria from Uncomplicated Malaria and Predict Clinical Outcome in African Children

(2009) Fiona E. Lovegrove et al.   PLoS One

ELEVATED SERUM ANGIOPOIETIN 2 LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS

(2009) Jonathan M. Siner et al.   SHOCK

Angiopoietin Balance in Septic Shock Patients Treated by Direct Hemoperfusion With Polymyxin B-immobilized Fiber

(2009) Itaru Ebihara et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Kinetics of Angiopoietin-2 in serum of multi-trauma patients: Correlation with patient severity

(2008) Evangelos J. Giamarellos-Bourboulis et al.   CYTOKINE

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

(2008) Shigetomo Fukuhara et al.   NATURE CELL BIOLOGY

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY

Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria

(2008) T. W. Yeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients

(2008) M van der Heijden et al.   THORAX

Acceleration of Diabetic Wound Healing by an Angiopoietin Peptide Mimetic

(2008) Paul Van Slyke et al.   TISSUE ENGINEERING PART A