Article
Gastroenterology & Hepatology
Gwang Hyeon Choi, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong
Summary: Plasma levels of Ang-2 in HCC patients correlated with liver function, tumor stage, and tumor invasiveness, showing better performance in predicting OS and PFS compared to AFP, Ang-1, or VEGF.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michal Mielnik, Aneta Szudy-Szczyrek, Iwona Homa-Mlak, Radoslaw Mlak, Martyna Podgajna-Mielnik, Aneta Goracy, Teresa Malecka-Massalska, Marek Hus
Summary: This study assessed the correlation between pretreatment serum concentrations of IL-6, IL-8, MCP-1, and VEGF and the clinical outcomes of MM patients. Results showed that IL-8 was significantly correlated with age, staging, performance status, anemia, kidney disease, and VEGF. Chemotherapy responders had lower IL-8, IL-6, and VEGF concentrations compared to non-responders. High levels of IL-6 were associated with a higher risk of disease progression and reduced overall survival.
Article
Immunology
Qianwen Cheng, Fei Zhao, Bo Zhang, Yuyang Zhang, Li Cai, Bing Qiao, Yu Hu, Chunyan Sun
Summary: This study aimed to explore the relationship between pretreatment cytokine status and overall survival in newly diagnosed multiple myeloma (NDMM) patients, and established a prognostic nomogram incorporating cytokines. Using multivariate Cox analysis, three key variables (lactate dehydrogenase, MIP-1 alpha, and creatinine) were included in the nomogram. The nomogram showed superior predictive power for overall survival compared to existing staging systems, accurately predicting 1-year, 2-year, and 3-year survival rates for NDMM patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haiyan Zhou, Tangting Chen, Yongjie Li, Jingcan You, Xin Deng, Ni Chen, Tian Li, Youkun Zheng, Rong Li, Mao Luo, Jianbo Wu, Liqun Wang
Summary: This study found that Tie-2 is modified by AGEs in diabetes, leading to the inhibition of Ang-1 signaling activation and angiogenesis. This finding provides a novel mechanism for Ang-1/Tie-2 signal dysfunction and angiogenesis failure in diabetic ischemic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aurelia Lamanuzzi, Ilaria Saltarella, Antonia Reale, Assunta Melaccio, Antonio Giovanni Solimando, Concetta Altamura, Grazia Tamma, Clelia Tiziana Storlazzi, Doron Tolomeo, Vanessa Desantis, Maria Addolorata Mariggio, Jean-Francois Desaphy, Andrew Spencer, Angelo Vacca, Benedetta Apollonio, Maria Antonia Frassanito
Summary: Extracellular vesicles (EVs) derived from fibroblasts play an important role in promoting angiogenesis in the bone marrow of multiple myeloma patients. The cargo of these EVs contains angiogenic cytokines that mediate this process. The uptake-independent and uptake-dependent mechanisms of FBEVs contribute to different stages of angiogenesis.
Review
Urology & Nephrology
Mei Li, Zoran Popovic, Chang Chu, Christoph Reichetzeder, Wolfgang Pommer, Bernhard K. Kramer, Berthold Hocher
Summary: Background: Angiopoietins (Ang) are essential angiogenic factors involved in angiogenesis, vascular maturation, and inflammation. The most studied angiopoietins, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), behave antagonistically to each other in vivo to sustain vascular endothelium homeostasis. While Ang-1 typically acts as the endothelium-protective mediator, its context-dependent antagonist Ang-2 can promote endothelium permeability and vascular destabilization, hence contributing to a poor outcome in vascular diseases via endothelial injury, vascular dysfunction, and microinflammation. The pathogenesis of kidney diseases is associated with endothelial dysfunction and chronic inflammation in renal diseases. Summary: Several preclinical studies report overexpression of Ang-2 in renal tissues of certain kidney disease models; additionally, clinical studies show increased levels of circulating Ang-2 in the course of chronic kidney disease, implying that Ang-2 may serve as a useful biomarker in these patients. However, the exact mechanisms of Ang-2 action in renal diseases remain unclear. Key Messages: We summarized the recent findings on Ang-2 in kidney diseases, including preclinical studies and clinical studies, aiming to provide a systematic understanding of the role of Ang-2 in these diseases.
Article
Cardiac & Cardiovascular Systems
Keijiro Ibuki, Teruhiko Imamura, Hideyuki Nakaoka, Shinya Takarada, Mako Okabe, Sayaka Ozawa, Koichiro Kinugawa, Keiichi Hirono
Summary: This study compared the serum angiopoietin-2 levels in pediatric patients after Fontan operation with those with congenital heart disease as control group. The results showed significantly elevated levels of angiopoietin-2 in the Fontan group, and a higher level of angiopoietin-2 was identified as an independent risk factor for death or Fontan-related adverse events.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dominika Bebnowska, Rafal Hrynkiewicz, Ewelina Grywalska, Marcin Pasiarski, Barbara Sosnowska-Pasiarska, Iwona Smarz-Widelska, Stanislaw Gozdz, Jacek Rolinski, Paulina Niedzwiedzka-Rystwej
Summary: The article discusses the prognostic value of immune system components in patients with multiple myeloma to aid in the development of new diagnostic and therapeutic directions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lin Wang, Shengnan Wang, Aijuan Xue, Jieru Shi, Cuifang Zheng, Ying Huang
Summary: Thalidomide can effectively reduce the levels of VEGF and Ang-2 in pediatric CD patients, thereby inhibiting angiogenesis in the intestines and potentially alleviating the disease.
Article
Oncology
Anna M. W. ten Voorde, Annemijn P. A. Wierenga, Rogier J. Nell, Pieter A. van der Velden, Gregorius P. M. Luyten, Robert M. Verdijk, Martine J. Jager
Summary: In uveal melanoma, ANG-2 is identified as an important prognostic factor, with high expression associated with high-risk tumors and metastasis development, making it a potential therapeutic target.
Review
Oncology
Anais Schavgoulidze, Titouan Cazaubiel, Aurore Perrot, Herve Avet-Loiseau, Jill Corre
Summary: Prognosis stratification is crucial for treatment choice in multiple myeloma, but current scores based on biochemical parameters and cytogenetics are imperfect. Cytogenetics and minimal residual disease have a major impact on prognosis, but fail to explain all the heterogeneity in outcomes.
Review
Biochemistry & Molecular Biology
Giuseppe Murdaca, Alessandro Allegra, Francesca Paladin, Fabrizio Calapai, Caterina Musolino, Sebastiano Gangemi
Summary: This study examines the role of molecules such as high-mobility group box-1, heat shock proteins, and S100 proteins in the induction of neoangiogenesis in multiple myeloma, highlighting their significance in disease progression. The modulation of the host immune system and inhibition of neoangiogenesis may serve as potential therapeutic targets for MM treatment, aiming to improve survival outcomes and reduce the risk of relapsed/refractory disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Danfeng Zhang, Jingcao Huang, Fangfang Wang, Hong Ding, Yushan Cui, Yan Yang, Juan Xu, Hongmei Luo, Yuhan Gao, Ling Pan, Yu Wu, Yuping Gong, Liping Xie, Zhigang Liu, Ying Qu, Li Zhang, Weiping Liu, Wenyan Zhang, Sha Zhao, Qing Yi, Ting Niu, Yuhuan Zheng
Summary: Multiple myeloma is a malignancy characterized by plasma cell accumulation in the bone marrow. Within the tumor microenvironment, macrophages in multiple myeloma exhibit pro-myeloma functions, which are modulated by the polycomb-group protein BMI1. Knockout of BMI1 in MM-associated macrophages leads to reduced proliferation, decreased expression of angiogenic factors, and loss of protection against chemotherapy-induced cell death, ultimately negating the pro-myeloma effects of these cells.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Craig T. Wallington-Beddoe, Rachel L. Mynott
Summary: New approaches are needed to stratify multiple myeloma patients based on prognosis and therapeutic decision-making, however, insufficient information currently exists to utilize biomarkers to tweak treatment. With the increasing complexity of drug classes used to treat multiple myeloma, clinically useful biomarkers are crucial in guiding personalized patient management.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Oncology
Ilaria Saltarella, Concetta Altamura, Carmen Campanale, Paola Laghetti, Angelo Vacca, Maria Antonia Frassanito, Jean-Francois Desaphy
Summary: Angiogenesis is a critical factor in multiple myeloma, affecting patients' prognosis, survival, and drug resistance. Various anti-angiogenic drugs targeting angiogenic cytokines and their receptors have been developed, along with standard antimyeloma drugs that also exhibit anti-angiogenic effects. This review examines the pharmacological profile and in vitro and in vivo anti-angiogenic effects of these therapies. Although direct targeting of angiogenic cytokines/receptors has shown limited efficacy, there is a need for a deeper understanding of the bone marrow angiogenic niche to develop novel multi-targeting anti-angiogenic therapies.
Review
Toxicology
Silvia Vivarelli, Chiara Costa, Michele Teodoro, Federica Giambo, Aristidis Michael Tsatsakis, Concettina Fenga
Summary: Non-communicable diseases (NCDs) are major global causes of mortality and morbidity. Unhealthy lifestyle habits are closely associated with NCDs, and improving these habits may help alleviate symptoms and prolong the life expectancy of affected individuals. Polyphenols (PPLs) derived from plants have shown positive results in preventing and treating NCDs and are considered safe.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
N. V. Tyshko, N. S. Nikitin, S. I. Shestakova, E. O. Sadykova, M. D. Trebukh, G. V. Guseva, N. V. Trusov, I. V. Aksenov, K. S. Golokhvast, A. Tsatsakis, V. A. Tutelyan
Summary: In a chronic model experiment on rats, the liver morphology, intensity of apoptosis, and activity of xenobiotic metabolism enzymes were studied after exposure to a mixture of 6 pesticides and lifelong diets with adequate and insufficient supply of water-soluble vitamins. The dose of each pesticide in the mixture did not exceed the acceptable daily intake (1 ADI). The findings suggest that chronic exposure to low doses of anthropogenic toxicants combined with permanent vitamin deficiency can cause various liver changes, including increased apoptosis activity, depletion of the cytochrome P450 system, steatosis, and inflammatory infiltration, posing a potential health risk.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Gennadiy Onishchenko, Natalia Nikolayeva, Valery Rakitskii, Alexandra Ilnitskaya, Andrey Filin, Aleksei Korolev, Elena Nikitenko, Elena Denisova, Andreas Tsakalof, Ekaterina Guseva, Sergey Kuzmin, Aristidis Tsatsakis
Summary: This study evaluated the health effects of combined or separate exposure to hazardous factors in plasma technology occupational environment on animal models. The results showed that exposure to noise or its combination with chemical factors led to non-specific changes in the CNS, especially in the case of joint exposure.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Magdalena Mititelu, Denisa Ioana Udeanu, Anca Oana Docea, Aristidis Tsatsakis, Daniela Calina, Andreea Letitia Arsene, Mirela Nedelescu, Sorinel Marius Neacsu, Bruno Stefan Velescu, Manuela Ghica
Summary: The release of heavy metals into the natural environment poses problems for ecosystems and human health. Honey can contain heavy metals from agricultural or industrial sources, and consuming contaminated honey can lead to serious health problems. This study aimed to determine the concentrations of heavy metals in honey and soil and assess the associated risks.
ENVIRONMENTAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Sidika Genc, Ali Taghizadehghalehjoughi, Yesim Yeni, Abbas Jafarizad, Ahmet Hacimuftuoglu, Dragana Nikitovic, Anca Oana Docea, Yaroslav Mezhuev, Aristidis Tsatsakis
Summary: In this study, the combination of Fe3O4 NPs and 5-FU showed a synergistic cytotoxic effect on Caco-2 cells at concentrations below the active drug threshold levels.
Article
Public, Environmental & Occupational Health
Ourania Anesti, Nafsika Papaioannou, Catherine Gabriel, Achilleas Karakoltzidis, Vazha Dzhedzheia, Ioannis Petridis, Antonios Stratidakis, Mike Dickinson, Milena Horvat, Janja Snoj Tratnik, Aristidis Tsatsakis, Spyros Karakitsios, Dimosthenis A. A. Sarigiannis
Summary: This study presents an integrated approach to investigating the impact of perinatal exposure to metals on child neurodevelopment in two cohorts carried out in Slovenia and Greece. The study found that heavy metal exposure during the perinatal period is associated with impaired mitochondrial respiration and oxidative stress, leading to developmental disorders in children. Additionally, factors such as diet, proximity to pollution sources, and socioeconomic and demographic characteristics also play a role in child neurodevelopment.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Chemistry, Medicinal
Betul Cicek, Ahmet Hacimuftuoglu, Mehmet Kuzucu, Ahmet Cetin, Yesim Yeni, Sidika Genc, Serkan Yildirim, Ismail Bolat, Mecit Kantarci, Mustafa Gul, Serhat Hayme, Dimitris Matthaios, Dimitra P. P. Vageli, Sotirios G. G. Doukas, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: According to population-based studies, lung cancer is the most common cause of cancer-related deaths worldwide in males, and its incidence among females is also increasing alarmingly. Sorafenib (SOR), a multitargeted protein kinase inhibitor used for the treatment of hepatocellular carcinoma and renal cell carcinoma, has been the subject of interest in preclinical and clinical trials for lung cancer. This study aimed to investigate the effects of SOR in diethylnitrosamine (DEN)-induced lung carcinogenesis and explore its mechanisms of action. The results showed that SOR reduced the levels of SOX-2, TNF-alpha, and IL-1 beta, and alleviated the histopathological damage caused by DEN-induced lung carcinogenesis. Immunohistochemical and immunofluorescence analysis also revealed that SOR treatment decreased the expression of COX-2 and JNK in DEN-intoxicated rats. These findings suggest that SOR inhibits lung precancerous lesions induced by DEN through reducing inflammation and SOX-2 levels.
Article
Environmental Sciences
Konstantin Pikula, Konstantin Kirichenko, Vladimir Chernousov, Sergey Parshin, Alexander Masyutin, Yulia Parshina, Anton Pogodaev, Alexander Gridasov, Aristidis Tsatsakis, Kirill Golokhvast
Summary: This study evaluated the aquatic toxicity of two suspension samples obtained from underwater welding using electrode and flux-cored wire on marine microalgae Attheya ussuriensis and Porphyridium purpureum. The results showed that the suspension obtained from welding with electrode had an acute toxic impact on A. ussuriensis, while both suspensions had chronic toxicity with a 40% growth rate inhibition in this microalga. However, P. purpureum showed tolerance to both suspensions due to the presence of an exopolysaccharide covering that prevented the toxic impact of metal cations.
Article
Toxicology
Michael Aschner, Anatoly V. Skalny, Rongzhu Lu, Abel Santamaria, Ji-Chang Zhou, Tao Ke, Mikhail Yu. Karganov, Aristides Tsatsakis, Kirill S. Golokhvast, Aaron B. Bowman, Alexey A. Tinkov
Summary: This review summarizes the existing data on the effects of toxic metals on HIF-1 signaling and its underlying mechanisms, with a special focus on the prooxidant effect of metals. The effect of metals on HIF-1 pathway varies depending on the cell type, ranging from down-regulation to up-regulation. Inhibition of HIF-1 signaling may contribute to hypoxic damage in cells, while metal-induced activation may promote tumor growth and contribute to the carcinogenic effects of heavy metals.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Toxicology
Yuliya V. Ryabova, Marina P. Sutunkova, Ilzira A. Minigalieva, Lada V. Shabardina, Tommaso Filippini, Aristides Tsatsakis
Summary: This paper provides a comprehensive summary of the toxicological studies conducted on selenium nanoparticles (NPs) using laboratory animals. In vivo studies have shown adverse effects of selenium NPs on laboratory animals, including reductions in body mass, changes in hepatotoxicity indices, and possible impairment of metabolic processes. However, no specific toxic action solely attributable to selenium has been identified. The LOAEL and NOAEL values are contradictory, and the relationship between the adverse effects of selenium NPs and exposure dose is controversial and diverse.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Oncology
Ozgur Celebi, Ali Taghizadehghalehjoughi, Demet Celebi, Robin Mesnage, Kirill Sergeevich Golokhvast, Andreea Letitia Arsene, Demetrios A. Spandidos, Aristidis Tsatsakis
Summary: The gut microbiota is important for maintaining health and regulating immune response. Probiotics and vitamins can improve microbial population and prevent tight junction protein breakdown. The study evaluated the effects of vitamins and probiotics on Escherichia coli and Staphylococcus aureus.
MOLECULAR MEDICINE REPORTS
(2023)
Editorial Material
Substance Abuse
Cornel Radu-Loghin, Karina Mocanu, Hani Al Gouhmani, Constantine Vardavas, Ioanna Lagou, Zinovia Plyta, Aikaterini Papathanasaki, Stella Vogiatzidaki, Alexander Vardavas, Manolis Tzatzarakis, Aristidis Tsatsakis, Filip-pos Filippidis, Christina Kyriakos, Esteve Fernandez, Olena Tigova, Cristina Martinez, Anna Mar Lopez Luque, Marius Eremia, Lucia Maria Lotrean, Antigona Trofor, Thomas Wenzl, Bill Simpson, Pippa Powell, Polina Starchenko, Angeliki Bakou, Eleni Asimaki, Victoria Vivilaki
TOBACCO PREVENTION & CESSATION
(2023)
Article
Chemistry, Medicinal
Sidika Genc, Tarik Yagci, Dimitra P. Vageli, Riza Dundar, Panagiotis G. Doukas, Sotirios G. Doukas, Maria Tolia, Nikolaos Chatzakis, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: This study found that serum exosomal miR-223, miR-146, and PTEN expression were significantly decreased, while miR-21 expression was significantly increased in LSCC patients. In addition, CRP and vitamin B12 levels were also altered. These results suggest that the expression of serum exosomal miR-223, miR-146, miR-21, as well as the changes in CRP and vitamin B12 levels, may serve as potential indicators of LSCC.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Oncology
Aristidis Tsatsakis, Elisavet Renieri, Dimitris Tsoukalas, Ana Maria Buga, Evangelia Sarandi, Elena Vakonaki, Persefoni Fragkiadaki, Athanasios Alegakis, Dragana Nikitovic, Daniela Calina, Demetrios A. Spandidos, Anca Oana Docea
Summary: This study evaluated the effects of a novel telomerase activator on telomere length and telomerase activity in aged rats. The nutraceutical formulation was found to reduce telomere shortening rate at lower dose and increase telomere length at higher dose. Telomerase activity was also increased in the treated rats.
MOLECULAR MEDICINE REPORTS
(2023)
Review
Medicine, Research & Experimental
Fotios Kakridonis, Spyros G. Pneumatikos, Elena Vakonaki, Aikaterini Berdiaki, Manolis N. Tzatzarakis, Persefoni Fragkiadaki, Demetrios A. Spandidos, Stella Baliou, Petros Ioannou, Eleftheria Hatzidaki, Dragana Nikitovic, Aristidis Tsatsakis, Elias Vasiliadis
Summary: This review summarizes the potential of telomere shortening as a biomarker for detecting the onset of osteoporosis. It found a weak association between telomere length and osteoporosis in some studies, suggesting that telomere shortening may be used as a biomarker for tracking the development and progression of osteoporosis.
BIOMEDICAL REPORTS
(2023)
