Article
Oncology
Yuxian Wu, Jinghai Gao, Xiaojun Liu
Summary: The study showed that upregulation of ANGPTL4 in ovarian cancer cells led to increased tumor angiogenesis, growth, and metastasis inhibition. Inactivation of VEGFR2 Y949 phosphorylation eliminated the tumor-suppressive effects of ANGPTL4 inhibition in spontaneous ovarian carcinoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Ruiyang Liu, Qingsong Gao, Steven M. Foltz, Jared S. Fowles, Lijun Yao, Julia Tianjiao Wang, Song Cao, Hua Sun, Michael C. Wendl, Sunantha Sethuraman, Amila Weerasinghe, Michael P. Rettig, Erik P. Storrs, Christopher J. Yoon, Matthew A. Wyczalkowski, Joshua F. McMichael, Daniel R. Kohnen, Justin King, Scott R. Goldsmith, Julie O'Neal, Robert S. Fulton, Catrina C. Fronick, Timothy J. Ley, Reyka G. Jayasinghe, Mark A. Fiala, Stephen T. Oh, John F. DiPersio, Ravi Vij, Li Ding
Summary: In this study, researchers conducted single-cell multi-omics profiling of samples from MM patients at different stages, identifying changes in immune cell composition throughout disease progression.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Jie Gao, Fang Li, Zihao Liu, Mengli Huang, Huoming Chen, Guoqing Liao, Jichang Meng, Qing Wang, Hui Zhao, Chenxi Li, Jing Ji, Shangli Cai, Nan Du
Summary: Bevacizumab plus chemotherapy is commonly used in advanced ovarian cancer, but the efficacy is not satisfactory. Genetic alterations in EGFR and HER2 are negative predictors of progression-free survival (PFS) in advanced OC patients treated with BV-based regimens, suggesting potential use of alternative targeted therapies.
Article
Biochemistry & Molecular Biology
Ni Yang, Yucong Zhang, Yi Huang, Jinhua Yan, Zonghao Qian, Han Li, Pengcheng Luo, Zhen Yang, Mandi Luo, Xiuxian Wei, Hao Nie, Lei Ruan, Yi Hao, Shangbang Gao, Kai Zheng, Cuntai Zhang, Le Zhang
Summary: This study explored the effects of serum FGF21 on vascular endothelial cells and found that FGF21 within the physiological concentration range has a beneficial effect on the cells, potentially through the regulation of SIRT1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Oncology
Andrzej J. Jakubowiak, Shaji Kumar, Rohan Medhekar, Huiling Pei, Patrick Lefebvre, Shuchita Kaila, Jianming He, Marie-Helene Lafeuille, Annelore Cortoos, Anil Londhe, Panagiotis Mavros, Thomas S. Lin, Saad Z. Usmani
Summary: This study demonstrates that the incorporation of daratumumab in frontline treatment regimens can reduce the risk of progression or death and improve response rates among autologous stem cell transplant-ineligible high-risk newly diagnosed multiple myeloma patients.
Article
Reproductive Biology
Kazuki Takasaki, Takayuki Ichinose, Yuko Miyagawa, Shiho Fukui, Kei Hashimoto, Haruka Nishida, Yuko Takahashi, Haruko Hiraike, Koji Saito, Yuko Sasajima, Kazunori Nagasaka
Summary: This study investigated two cases of granulosa cell tumors (GCTs) to find a biomarker for evaluating treatment and predicting recurrence. The findings suggest that serum vascular endothelial growth factor (VEGF) levels can be used as a clinical biomarker for disease progression in GCTs and to determine the efficacy of bevacizumab therapy.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Ha -Ram Park, Anahita Shiva, Portia Cummings, Seoyeon Kim, Sungsoo Kim, Eunhyeong Lee, Alessandra Leong, Subrata Chowdhury, Carrie Shawber, Richard Carvajal, Gavin Thurston, Joon-Yong An, Amanda W. Lund, Hee Won Yang, Minah Kim
Summary: The position of T-cells in the tumor microenvironment affects their ability to encounter the tumor and kill it. The vascular destabilizing factor ANGPT2 causes vascular integrity issues in the tumor periphery, leading to a lack of T-cell infiltration in the tumor core, which is associated with a poor response to immunotherapy.
Article
Biochemistry & Molecular Biology
Barbara Vizio, Ornella Bosco, Ezio David, Gian Paolo Caviglia, Maria Lorena Abate, Martina Schiavello, Angela Pucci, Antonina Smedile, Gianluca Paraluppi, Renato Romagnoli, Enrico Lupia, Graziella Bellone, Giuseppe Montrucchio
Summary: The study revealed that THPO and VEGF-A expression levels were significantly elevated in tumor tissues compared to liver cirrhosis tissues in HCC patients. There was a linear correlation between THPO and VEGF-A transcripts in HCC, indicating a potential interdependent regulation between the two growth factors in promoting cellular growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Yu Jia Shen, Yuji Mishima, Jiantao Shi, Romanos Sklavenitis-Pistofidis, Robert A. Redd, Michele Moschetta, Salomon Manier, Aldo M. Roccaro, Antonio Sacco, Yu-Tzu Tai, Francois Mercier, Yawara Kawano, Nang Kham Su, Brianna Berrios, John G. Doench, David E. Root, Franziska Michor, David T. Scadden, Irene M. Ghobrial
Summary: Clonal evolution plays a key role in tumor progression, dissemination, and relapse in multiple myeloma (MM). By developing a clone-tracking system, researchers studied clonal behavior in the bone marrow microenvironment, identifying specific clones able to adapt and colonize distant sites. RNA sequencing revealed a progression signature in MM tumor cells, leading to the prediction of 28 master regulators, with HMGA1 and PA2G4 validated as key players in MM progression and dissemination, impacting cell functions like proliferation, migration, and adhesion. This study successfully replicates key characteristics of human MM disease progression and suggests potential therapeutic targets.
Article
Biotechnology & Applied Microbiology
Lingchun Kong, Jingjing Li, Yuqin Yang, Huixin Tang, Hong Zou
Summary: This study found that Paeoniflorin (PF) can alleviate the progression of retinal vein occlusion (RVO) by inhibiting the HIF-1 alpha/VEGF/STAT3 pathway. The results of this study may provide theoretical knowledge for exploring novel treatments for RVO patients.
Review
Cell Biology
Remo Poto, Stefania Loffredo, Francesco Palestra, Gianni Marone, Vincenzo Patella, Gilda Varricchi
Summary: Chronic obstructive pulmonary disease (COPD) is a disease characterized by chronic inflammation in the lungs, leading to progressive and irreversible airflow obstruction. COPD development is primarily caused by persistent lung inflammation in response to various stimuli. Angiogenesis and lymphangiogenesis are seen in the airway inflammation of COPD. Inflammatory cells and structural cells contribute to inflammation and angiogenesis in COPD.
Article
Multidisciplinary Sciences
Yukari Koya, Hiromi Nara, Shigenori Yagi, Chihoko Ueno, Masazumi Kamohara
Summary: ASP4021, a novel engineered tetra-valent agonistic antibody, can specifically activate the Tie2 receptor and inhibit apoptosis, significantly suppressing vascular permeability increase. It may be a potential therapeutic candidate for diseases associated with vascular weakness such as diabetic retinopathy.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Rui Wang, Moua Yang, Longguang Jiang, Mingdong Huang
Summary: This review focuses on the various functions of the Ang-Tie axis in inflammation-induced vascular permeability, vascular remodeling, atherosclerosis, ocular angiogenesis, tumor angiogenesis, and metastasis. Therapeutic approaches to the Ang-Tie axis are also discussed.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaomin Zhang, Jieli Yang, Sai Chen, Chang Liu, Zhenhua Wang, Hefei Ren, Lin Zhou
Summary: Approximately 31% of patients with multiple myeloma (MM) have pre-existing hypertension. Pre-existing hypertension is significantly associated with a lower progression-free survival (PFS) in MM patients, and it is an independent risk factor for PFS reduction in MM patients.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Pathology
Nupur Das, Meetu Dahiya, Ritu Gupta, Lalit Kumar, Lata Rani, Anubha Gupta, Akanksha Farswan, Atul Sharma, Om Dutt Sharma
Summary: This study analyzed the relationship between different response indicators and prognosis in patients with multiple myeloma. The results showed that deepening of both conventional response and measurable residual disease was associated with better survival outcomes. The neoplastic plasma cell index was found to be a better determinant of survival compared to measurable residual disease.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Hematology
Deepshi Thakral, Vivek Kumar Singh, Ritu Gupta, Nitu Jha, Aafreen Khan, Gurvinder Kaur, Sandeep Rai, Vijay Kumar, Manisha Supriya, Sameer Bakhshi, Rachna Seth
Summary: Single-cell sequencing was used to investigate the transcriptional heterogeneity of CD34 + enriched leukemic stem cells in pediatric AML. The study identified unique leukemic stem cell clusters for each patient and revealed intra-patient heterogeneity. Gene expression analysis showed upregulation of genes involved in non-coding RNA processing, ribonucleoprotein assembly, apoptotic processes, cytokine stimulus response, and negative regulation of transcription in LSC-enriched clusters. Validation confirmed the upregulation of specific genes and kinases in LSC-enriched clusters, which correlated with MRD status and survival outcomes. These findings highlight the diversity and potential therapeutic targets of AML LSC.
ANNALS OF HEMATOLOGY
(2023)
Article
Medical Laboratory Technology
Diya Roy, Sanjay Sriram, Aanchal Kakkar, Rajeev Kumar, Kavneet Kaur, Deepali Jain, Atul Sharma, Alok Thakar
Summary: INSM1 immunocytochemistry is highly sensitive and specific and can reliably be used as a single marker to support the cytomorphology for a confirmatory diagnosis of metastatic ONB, even on direct smears if a cell block is not available.
DIAGNOSTIC CYTOPATHOLOGY
(2023)
Article
Medical Laboratory Technology
Akhila Gopakumar, Aanchal Kakkar, Kavneet Kaur, Kapil Sikka, Alok Thakar, Atul Sharma, Deepali Jain
Summary: Inactivating mutations of SMARCA4 and loss of BRG1 immunoexpression were found in majority of sinonasal teratocarcinosarcomas (TCS). Fine needle aspiration cytology (FNAC) can be used for diagnosis of TCS with nodal metastasis. The cytological features of TCS have not been described before. In this case, FNAC from cervical lymph nodes showed various cell types including discohesive tumor cells, cohesive fragments, loosely cohesive cells, and rhabdoid cells. BRG1 immunostaining confirmed the diagnosis of metastatic SMARCA4-deficient TCS. The diverse cytological features of SMARCA4-deficient TCS can overlap with other regional metastatic tumors, highlighting the importance of ancillary tests for accurate diagnosis.
DIAGNOSTIC CYTOPATHOLOGY
(2023)
Review
Hematology
Surabhi Jain, Prashant Ramteke, Ajay Gogia, Trisha Mandal, Mukul Aggarwal, Jasmita Dass, Mehar Chand Sharma, Manoranjan Mahapatra, Raja Parmanik, Sameer Bakhshi, Atul Sharma, Saumyaranjan Mallick
Summary: Primary splenic lymphomas are rare, with the majority being secondary to an extra-splenic lymphoma. This retrospective study analyzed the epidemiological profile of splenic lymphoma and reviewed the literature. A total of 33 lymphomas were diagnosed in the spleen, with primary splenic lymphomas constituting 84.84% of the cases. Splenic marginal zone lymphomas were the most common subtype. Splenectomy was the main treatment for splenic marginal zone lymphomas, while chemotherapy and radiotherapy were used for other lymphomas. Proper evaluation by pathologists is crucial for appropriate management.
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2023)
Article
Hematology
Sandeep Rai, Nupur Das, Ritu Gupta, Lalit Kumar, Atul Sharma, Saroj Singh, Vijay K. K. Prajapati
Summary: This study examines the expression profile of CD229 in multiple myeloma and its potential as a marker for plasma cells. The results show that CD229 has a relatively homogenous expression in different bone marrow compartments and can be used for the identification of plasma cells. However, it cannot reliably discriminate between normal plasma cells and aberrant plasma cells, limiting its utility in diagnosis and measurable residual disease assessment.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Article
Hematology
Smeeta Gajendra, Ritu Gupta, Deepshi Thakral, Sanjeev Kumar Gupta, Garima Jain, Sameer Bakhshi, Atul Sharma, Ranjeet Kumar Sahoo, Lalit Kumar, Sandeep Rai, Saroj Singh, Ashish Datt Upadhyay
Summary: CD34-negative HLA-DR-negative non-APL AML is associated with NPM1 and FLT3-ITD mutations, older age at diagnosis, DIC, higher total leukocyte count, higher blast counts, and normal karyotype compared to CD34-positive HLA-DR-negative AML group. Co-occurrence of NPM1 and FLT3-ITD mutations is exclusively seen in the CD34-negative HLA-DR-negative group. There is poor overall survival in CD34-positive HLA-DR-negative AML compared to CD34-negative HLA-DR-negative AML cases.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Letter
Biophysics
Anjali Mookerjee, Ritu Gupta, Rakesh Kumar, Atul Sharma, Ravindra Mohan Pandey, Lalit Kumar
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Aparna Sharma, Rohit Reddy, Raja Pramanik, Ranjit Kumar Sahoo, Seema Kaushal, K. P. Haresh, Sunil Kumar, Lalit Kumar, Atul Sharma, Atul Batra
Summary: This study retrospectively analyzed patients with mediastinal germ cell tumors registered at our center from 2010 to 2020. A total of 30 patients were identified and treated with multimodality management including chemotherapy, surgery, and radiation therapy. The three-year relapse-free survival rate was 69.6% and the overall survival rate at three years was 73.4%. Patients with seminomatous tumor had a better prognosis compared to those with nonseminomatous tumor.
CANCER INVESTIGATION
(2023)
Article
Mathematics, Applied
Vinay Prasad, Atul Sharma, Salil S. Kulkarni
Summary: This paper investigates the chaotic advection caused by the interaction between flexible elliptical-solids and a laminar lid-driven cavity flow. The study involves multiple neutrally buoyant elliptical-solids of different numbers, and demonstrates the periodic and aperiodic states of the fluid and solid motion as well as the enhancement of chaotic advection. The findings show that the chaotic advection increases up to a certain number of solids and then decreases, revealing a novel technique for enhancing chaotic advection based on the motion of multiple deformable-solids.
Review
Otorhinolaryngology
Sataksi Chatterjee, Naomi Kiyota, Richa Vaish, Atul Sharma, Makoto Tahara, Vanita Noronha, Kumar Prabhash, Anil D'Cruz
Summary: Concurrent chemoradiotherapy with 3-weekly cisplatin has been the standard treatment for locoregionally advanced head and neck cancer. However, concerns about toxicity, compliance, and real-world applicability have led to exploration of weekly cisplatin chemoradiotherapy as an alternative. A literature review comparing the two regimens was conducted, highlighting the noninferiority of the weekly regimen in both adjuvant and definitive settings.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Hematology
Smeeta Gajendra, Shilpa Anupurba, Ritu Gupta, Saumyaranjan Mallick, Devasis Panda, Deepshi Thakral, Sanjeev Kumar Gupta, Sameer Bakhshi, Rachna Seth, Sandeep Rai, Vijay K. Prajapati, Saroj Singh
Summary: AML with RAM immunophenotype is a distinct subtype of AML characterized by strong CD56 expression and dim to negative expression of CD45, HLA-DR, and CD38. It is an aggressive leukemia with poor response to treatment and frequent relapses.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Review
Hematology
Nupur Das, Smeeta Gajendra, Ritu Gupta
Summary: There is a diagnostic challenge in distinguishing between benign B-cell precursors (HG) and malignant B-lymphoid blasts (BLBs), but expression patterns of immunophenotypic markers can effectively differentiate HGs from BLBs. However, the relevance of flow cytometric immunophenotyping in evaluating B-cell compartment is still unclear. This review summarizes current flow cytometric data on HGs and BLBs and introduces the utility of radar plot for comprehensive representation of B-cell subsets and their differentiation from BLBs.
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2023)
Article
Engineering, Multidisciplinary
Kuntal Patel, Javed Shaikh, Absar Lakdawala, Atul Sharma
Summary: This paper proposes an Adaptive interface-Mesh un-Refinement (AiMuR) based Sharp-Interface Level-Set-Method (SI-LSM) for uniform and non-uniform Cartesian-Grid. The AiMuR dynamically un-refines the Cartesian grid away from the interface, specifically for the interface solver. A detailed numerical methodology is presented for the AiMuR and ghost-fluid method based SI-LSM, and it is shown through qualitative and quantitative performance studies that the AiMuR based SI-LSM outperforms the traditional SI-LSM.
SADHANA-ACADEMY PROCEEDINGS IN ENGINEERING SCIENCES
(2023)
Meeting Abstract
Hematology
Anita Chopra, Aparna Ningombam, Deepak Verma, Rajive Kumar, Jay Singh, M. Shadab Ali, Avnish Pandey, Inder Singh, Sameer Bakhshi, Atul Sharma, Deepam Pushpam, Jayanth Palanichamy, Pranay Tanwar, Amar Singh
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
