Amelioration of sepsis by TIE2 activation–induced vascular protection

Vasculotide reduces endothelial permeability and tumor cell extravasation in the absence of binding to or agonistic activation of Tie2

(2015) F. T. Wu et al.   EMBO Molecular Medicine

Intravital imaging of intestinal lacteals unveils lipid drainage through contractility

(2015) Kibaek Choe et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial barrier dysfunction in septic shock

(2015) S. M. Opal et al.   JOURNAL OF INTERNAL MEDICINE

The Tie2-agonist Vasculotide rescues mice from influenza virus infection

(2015) Michael G. Sugiyama et al.   Scientific Reports

The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells

(2015) Soniya Savant et al.   Cell Reports

Genetic Dissection of Tie Pathway in Mouse Lymphatic Maturation and Valve Development

(2014) Bin Shen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lung-Targeted RNA Interference Against Angiopoietin-2 Ameliorates Multiple Organ Dysfunction and Death in Sepsis

(2014) Thomas Stiehl et al.   CRITICAL CARE MEDICINE

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

(2014) Jikui Shen et al.   JOURNAL OF CLINICAL INVESTIGATION

An extracorporeal blood-cleansing device for sepsis therapy

(2014) Joo H Kang et al.   NATURE MEDICINE

Strategies to improve drug development for sepsis

(2014) Mitchell P. Fink et al.   NATURE REVIEWS DRUG DISCOVERY

Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance

(2014) A. L. Rasmussen et al.   SCIENCE

Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart

(2014) Yoh Arita et al.   Nature Communications

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

(2013) Tilman Ziegler et al.   JOURNAL OF CLINICAL INVESTIGATION

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Severe Sepsis and Septic Shock

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Angiopoietin-1 Guides Directional Angiogenesis Through Integrin  v 5 Signaling for Recovery of Ischemic Retinopathy

(2013) J. Lee et al.   Science Translational Medicine

Dysregulation of the angiopoietin–Tie-2 axis in sepsis and ARDS

(2013) Samir M Parikh   Virulence

Angiopoietin-2 Functions as a Tie2 Agonist in Tumor Models, Where It Limits the Effects of VEGF Inhibition

(2012) C. Daly et al.   CANCER RESEARCH

Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*

(2012) Sascha David et al.   CRITICAL CARE MEDICINE

Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis

(2012) Tanja Holopainen et al.   JNCI-Journal of the National Cancer Institute

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax

(2012) C. C. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orchestral actions of angiopoietin-1 in vascular regeneration

(2012) Gou Young Koh   TRENDS IN MOLECULAR MEDICINE

Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality

(2011) Sascha David et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis

(2011) Sascha David et al.   CYTOKINE

Broken Barriers: A New Take on Sepsis Pathogenesis

(2011) N. M. Goldenberg et al.   Science Translational Medicine

Critical care and the global burden of critical illness in adults

(2010) Neill KJ Adhikari et al.   LANCET

A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models

(2010) J. L. Brown et al.   MOLECULAR CANCER THERAPEUTICS

Stabilized imaging of immune surveillance in the mouse lung

(2010) Mark R Looney et al.   NATURE METHODS

Sepsis and Endothelial Permeability

(2010) Warren L. Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

(2010) N. R. London et al.   Science Translational Medicine

Degradation of the endothelial glycocalyx is associated with chylomicron leakage in mouse cremaster muscle microcirculation

(2010) Alina Constantinescu et al.   THROMBOSIS AND HAEMOSTASIS

Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx

(2009) Andrew H.J. Salmon et al.   CARDIOVASCULAR RESEARCH

Construction of a large synthetic human scFv library with six diversified CDRs and high functional diversity

(2009) Hye Young Yang et al.   MOLECULES AND CELLS

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols

Breaking the wall: targeting of the endothelium by pathogenic bacteria

(2009) Emmanuel Lemichez et al.   NATURE REVIEWS MICROBIOLOGY

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ELEVATED SERUM ANGIOPOIETIN 2 LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS

(2009) Jonathan M. Siner et al.   SHOCK

Genistein protects the kidney from cisplatin-induced injury

(2008) Mi Jeong Sung et al.   KIDNEY INTERNATIONAL

High-level Expression and Purification of a Designed Angiopoietin-1 Chimeric Protein, COMP-Ang1, Produced in Chinese Hamster Ovary Cells

(2008) Su-Jeong Hwang et al.   PROTEIN JOURNAL

Host–pathogen interactions in sepsis

(2007) Tom van der Poll et al.   LANCET INFECTIOUS DISEASES