Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes

Seroprevalence and Serointensity of Latent Toxoplasma gondii in a Sample of Elderly Adults With and Without Alzheimer Disease

(2016) Cynthia E. Perry et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Infectious disease burden and cognitive function in young to middle-aged adults

(2016) Shawn D. Gale et al.   BRAIN BEHAVIOR AND IMMUNITY

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

TREM2 regulates microglial cell activation in response to demyelination in vivo

(2015) Claudia Cantoni et al.   ACTA NEUROPATHOLOGICA

Therapeutic effects of glatiramer acetate and grafted CD115+monocytes in a mouse model of Alzheimer’s disease

(2015) Yosef Koronyo et al.   BRAIN

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Cerebral nitric oxide represses choroid plexus NF B-dependent gateway activity for leukocyte trafficking

(2015) K. Baruch et al.   EMBO JOURNAL

Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis

(2015) Sarah Mundt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease

(2015) Jessica M. Collins et al.   EXPERIMENTAL NEUROLOGY

Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer’s disease

(2015) Nicholas H. Varvel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer’s disease–like mice

(2015) Stefan Prokop et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ly6ChighMonocytes Control Cerebral Toxoplasmosis

(2015) Aindrila Biswas et al.   JOURNAL OF IMMUNOLOGY

Immunization with a Myelin-Derived Antigen Activates the Brain's Choroid Plexus for Recruitment of Immunoregulatory Cells to the CNS and Attenuates Disease Progression in a Mouse Model of ALS

(2015) G. Kunis et al.   JOURNAL OF NEUROSCIENCE

Amyloid   Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases

(2015) M. Brkic et al.   JOURNAL OF NEUROSCIENCE

Nuclear Receptors License Phagocytosis by Trem2+ Myeloid Cells in Mouse Models of Alzheimer's Disease

(2015) J. C. Savage et al.   JOURNAL OF NEUROSCIENCE

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Persistence ofToxoplasma gondiiin the central nervous system: a fine-tuned balance between the parasite, the brain and the immune system

(2015) N. Blanchard et al.   PARASITE IMMUNOLOGY

Toxoplasma gondii-induced neuronal alterations

(2015) A. Parlog et al.   PARASITE IMMUNOLOGY

Intravenous Infusion of Monocytes Isolated from 2-Week-Old Mice Enhances Clearance of Beta-Amyloid Plaques in an Alzheimer Mouse Model

(2015) Lindsay A. Hohsfield et al.   PLoS One

Chronic murine toxoplasmosis is defined by subtle changes in neuronal connectivity

(2014) A. Parlog et al.   Disease Models & Mechanisms

Reassessment of the Role of Aromatic Amino Acid Hydroxylases and the Effect of Infection by Toxoplasma gondii on Host Dopamine

(2014) Zi T. Wang et al.   INFECTION AND IMMUNITY

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

(2014) Marie Orre et al.   NEUROBIOLOGY OF AGING

Alzheimer’s and ABC transporters — new opportunities for diagnostics and treatment

(2014) Jens Pahnke et al.   NEUROBIOLOGY OF DISEASE

Association between latent toxoplasmosis and cognition in adults: a cross-sectional study

(2014) S. D. GALE et al.   PARASITOLOGY

The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis

(2014) Stefan Bereswill et al.   Gut Pathogens

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

(2014) Nico P. Dantuma et al.   Frontiers in Molecular Neuroscience

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

Similar herpes zoster incidence across Europe: results from a systematic literature review

(2013) Sybil Pinchinat et al.   BMC INFECTIOUS DISEASES

Reactive glia show increased immunoproteasome activity in Alzheimer’s disease

(2013) Marie Orre et al.   BRAIN

Toxoplasma gondii impairs memory in infected seniors

(2013) Patrick D. Gajewski et al.   BRAIN BEHAVIOR AND IMMUNITY

Reduced Alzheimer’s Disease Pathology by St. John’s Wort Treatment is Independent of Hyperforin and Facilitated by ABCC1 and Microglia Activation in Mice

(2013) Jacqueline Hofrichter et al.   Current Alzheimer Research

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

(2013) Michal Schwartz et al.   EMBO JOURNAL

Functional Macrophage Heterogeneity in a Mouse Model of Autoimmune Central Nervous System Pathology

(2013) A. London et al.   JOURNAL OF IMMUNOLOGY

Impaired mitochondrial energy production and ABC transporter function—A crucial interconnection in dementing proteopathies of the brain

(2013) Jens Pahnke et al.   MECHANISMS OF AGEING AND DEVELOPMENT

TREM2 in Alzheimer’s disease

(2013) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

NLRP3 inflammasome activation: CD36 serves double duty

(2013) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection

(2013) John R Grainger et al.   NATURE MEDICINE

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice

(2013) Róisín M. McManus et al.   NEUROBIOLOGY OF AGING

Neuroinflammation: The role and consequences

(2013) Monty Lyman et al.   NEUROSCIENCE RESEARCH

Mice Infected with Low-Virulence Strains of Toxoplasma gondii Lose Their Innate Aversion to Cat Urine, Even after Extensive Parasite Clearance

(2013) Wendy Marie Ingram et al.   PLoS One

Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression

(2013) Dan Frenkel et al.   Nature Communications

Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta

(2013) Jean-Philippe Michaud et al.   Cell Reports

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease

(2013) Ayman ElAli et al.   Frontiers in Physiology

Role of ABC Transporters in the Pathogenesis of Alzheimer’s Disease

(2012) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis

(2012) Katja Scheffler et al.   ACTA NEUROPATHOLOGICA

Prolonged elevation in hippocampal Aβ and cognitive deficits following repeated endotoxin exposure in the mouse

(2012) Marielle S. Kahn et al.   BEHAVIOURAL BRAIN RESEARCH

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Influenza Infection Induces Neuroinflammation, Alters Hippocampal Neuron Morphology, and Impairs Cognition in Adult Mice

(2012) H. A. Jurgens et al.   JOURNAL OF NEUROSCIENCE

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Harnessing monocyte-derived macrophages to control central nervous system pathologies: no longer ‘if’ but ‘how’

(2012) Ravid Shechter et al.   JOURNAL OF PATHOLOGY

Unknown

(2012) Gaelle Naert et al.   MOLECULAR MEDICINE

Review: Systemic inflammation and Alzheimer's disease

(2012) C. Holmes   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toxoplasma gondii Actively Inhibits Neuronal Function in Chronically Infected Mice

(2012) Fahad Haroon et al.   PLoS One

Immune response and immunopathology during toxoplasmosis

(2012) Christopher D. Dupont et al.   Seminars in Immunopathology

The diverse roles of monocytes in inflammation caused by protozoan parasitic diseases

(2012) Meru Sheel et al.   TRENDS IN PARASITOLOGY

Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APPSwe/PS1 mice

(2012) Gaëlle Naert et al.   Frontiers in Cellular Neuroscience

Chitinase Dependent Control of Protozoan Cyst Burden in the Brain

(2012) J. Philip Nance et al.   PLoS Pathogens

T-Cell Production of Matrix Metalloproteinases and Inhibition of Parasite Clearance by TIMP-1 During Chronic Toxoplasma Infection in the Brain

(2011) Robin T Clark et al.   ASN Neuro

Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease

(2011) Wei Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Assessing the contribution of inflammation in models of Alzheimer's disease: Figure 1

(2011) Hannah Johnston et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Determination of Spatial and Temporal Distribution of Microglia by 230nm-High-Resolution, High-Throughput Automated Analysis Reveals Different Amyloid Plaque Populations in an APP/PS1 Mouse Model of Alzheimers Disease

(2011) Katja Scheffler et al.   Current Alzheimer Research

Emerging roles of pathogens in Alzheimer disease

(2011) Judith Miklossy   EXPERT REVIEWS IN MOLECULAR MEDICINE

Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

(2011) Markus Krohn et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppression of Alzheimer's Disease-Related Phenotypes by Expression of Heat Shock Protein 70 in Mice

(2011) T. Hoshino et al.   JOURNAL OF NEUROSCIENCE

Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

(2011) A. Mildner et al.   JOURNAL OF NEUROSCIENCE

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression

(2011) Stefan J. Teipel et al.   PROGRESS IN NEUROBIOLOGY

Could Toxoplasma gondii Have any Role in Alzheimer Disease?

(2010) Ozge Yilmaz Kusbeci et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress

(2010) Ulrike Seifert et al.   CELL

Reduced Immunoproteasome Formation and Accumulation of Immunoproteasomal Precursors in the Brains of Lymphocytic Choriomeningitis Virus-Infected Mice

(2010) M. Kremer et al.   JOURNAL OF IMMUNOLOGY

Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cognitive behavior despite widespread brain pathology

(2010) Maria Gulinello et al.   MICROBES AND INFECTION

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria

(2009) A.-M. Sponaas et al.   BLOOD

Macrophages Promote Axon Regeneration with Concurrent Neurotoxicity

(2009) J. C. Gensel et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease and blood–brain barrier function—Why have anti-β-amyloid therapies failed to prevent dementia progression?

(2009) Jens Pahnke et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii

(2008) Ildiko R. Dunay et al.   IMMUNITY

Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection

(2008) Gretchen Hermes et al.   Journal of Neuroinflammation

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function

(2007) S. Lesné et al.   NEUROSCIENCE