Article
Biochemistry & Molecular Biology
Jihye Yoo, Jiyoung Park, Darong Kim, Yeonjoo Huh, Hea-Young Park Choo, Hyun Ae Woo
Summary: By synthesizing 12 novel compounds and evaluating their biological activities, it was found that 4 compounds exhibited strong inhibitory activities on IL-1 beta and IL-6 mRNA expression. Further in vivo activity evaluation indicated that 2 compounds significantly decreased mRNA levels of IL-1 beta, IL-6, and TNF-alpha.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Houmin Lin, Steven Grant Dixon, Wei Hu, Eric D. Hamlett, Junfei Jin, Adviye Ergul, Gavin Y. Wang
Summary: Research suggests that the accumulation of amyloid beta (Aβ) plaques in the brain is a key factor in the development of Alzheimer's disease (AD). This study found that Aβ(1-40) oligomers stimulate the expression of IL-6 in human microglial cells. The activation of p38 MAPK is associated with this increase in IL-6. Inhibition of p38 MAPK can prevent Aβ-induced IL-6 production. These findings indicate that targeting p38 MAPK could be a potential approach to reduce neuroinflammation caused by Aβ accumulation in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, General & Internal
Rebecca Pakradooni, Nishka Shukla, Kalpana Gupta, Jatinder Kumar, Ilaha Isali, Ahmed O. Khalifa, Sanjeev Shukla
Summary: Growth signals are crucial for cancer progression, with IGF-1 and IL-6 known to activate downstream mechanisms. Modulating these pathways may offer therapeutic potential for disease outcome. Diosmetin shows promise as a novel therapeutic target in prostate cancer treatment by inhibiting the progression through Rictor/AKT/PKC alpha pathway.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Deeksha Mohan, Heather L. Sherman, Ankita Mitra, Rebecca Lawlor, Sudarvili Shanthalingam, Jacob Ullom, Elena L. Pobezinskaya, Guodong Zhang, Barbara A. Osborne, Leonid A. Pobezinsky, Gregory N. Tew, Lisa M. Minter
Summary: CD4 T cells undergo metabolic and transcriptional changes to differentiate into T helper (Th) cells. Inflammatory environments can induce plasticity between regulatory T (Treg) cells and Th17 cells. Protein Kinase C theta (PKCθ) promotes Th17 differentiation while negatively regulating Treg differentiation. Liver kinase B1 (LKB1), encoded by Stk11, is necessary for Treg survival and function.
MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ji Sue Baik, You Na Seo, Young-Choon Lee, Joo Mi Yi, Man Hee Rhee, Moon-Taek Park, Sung Dae Kim
Summary: This study demonstrates that ionizing radiation activates the p38 MAPK-NLRC4-caspase-1 pathway in macrophages, leading to increased IL-1 beta production in response to lipopolysaccharide treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Christian Koenig, Enrique Vazquez, Sabrina Ess, Matthias Ebbinghaus, Bjoern Vorpahl, Andrea Ebersberger, Hans-Georg Schaible
Summary: Both spinal TNF and IL-6 contribute to mechanical spinal hyperexcitability in inflammatory pain states, with IL-6 potentially mediating TNF effects. IL-1 beta, also involved in inflammatory pain, induces spinal hyperexcitability, with TNF limiting its effects through IL-6 signaling. TNF stimulates the release of IL-1Ra, an endogenous IL-1 beta antagonist, which may modulate the effects of IL-1 beta on spinal excitability.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Orthopedics
Jinfeng Lu, Miao Yu, Jia Li
Summary: The activation of PKC-delta by IL-1beta can promote chondrocyte apoptosis in osteoarthritis through the JNK and p38 MAPK signaling pathways. The expression of PKC-delta is positively correlated with the degree of cartilage degeneration, p38 protein expression, and apoptosis rate. PKC-delta activation can upregulate JNK and p38 phosphorylation and expression, leading to increased caspase-3 and BAX levels and ultimately promoting OA progression.
Article
Cell Biology
Christoph Schultheiss, Edith Willscher, Lisa Paschold, Cornelia Gottschick, Bianca Klee, Svenja-Sibylla Henkes, Lidia Bosurgi, Jochen Dutzmann, Daniel Sedding, Thomas Frese, Matthias Girndt, Jessica I. Hoell, Michael Gekle, Rafael Mikolajczyk, Mascha Binder
Summary: Post-acute sequelae of COVID-19 (PASC) is a global problem with unknown molecular drivers. A study found that 67.8% of participants, mostly with mild infections, reported PASC, with symptoms including fatigue, dyspnea, and concentration deficit. These symptoms persisted in 60% of participants over an average 8-month follow-up period. PASC was associated with elevated plasma levels of IL-18, IL-6, and TNF.
CELL REPORTS MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
I-Ting Lin, Yu-Han Lin, Wei-Shiung Lian, Feng-Sheng Wang, Re-Wen Wu
Summary: Spinal epidural fibrosis is characterized by excessive scar formation in the dura and nerve roots, contributing to the failed back surgery syndrome. The microRNA-29a (miR-29a) has been found to inhibit fibrotic matrix production in various tissues, but its role in spinal epidural scarring remained unclear. This study showed that miR-29a attenuated fibrogenic activity and reduced fibrotic matrix formation in the epidural tissue of transgenic mice. Furthermore, miR-29aTg also protected against laminectomy-induced damage and could assess walking patterns and movement activity. Immunohistochemistry staining indicated reduced expression of IL-6, TGF-beta1, and Dnmt3b in miR-29aTg mice compared to wild-type mice. These findings highlight the epigenetic regulation of miR-29a in reducing spinal epidural fibrosis and preserving spinal cord integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zhaohua Tang, Gang Yang, Zhengbu Liao, Feilan Chen, Song Chen, Wentao Wang, Gang Huo, Xiaochuan Sun, Xiaoshu Wang
Summary: This study found that TSO IIA can alleviate astrocytic swelling caused by ischemia-reperfusion-like injury in an in vitro model. The protective mechanism may involve the activation of the HMGB1/RAGE/NF-kappa B/IL-6 pro-inflammatory axis.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Amitha Muraleedharan, Noa Rotem-Dai, Itai Strominger, Nikhil Ponnoor Anto, Noah Isakov, Alon Monsonego, Etta Livneh
Summary: This study highlights the role of astrocyte-specific stress-activated and anti-apoptotic kinase PKC eta in reacting astrocytes in Alzheimer's disease, contributing to neuroinflammation and potentially regulating IL-6 release through the NF-kappa B signaling pathway.
Article
Multidisciplinary Sciences
Li Zhou, Chuangang Tang, Xiaoxin Li, Fang Feng
Summary: There is growing evidence that inflammatory responses play significant roles in malignancies. This study investigated the impact of the pro-inflammatory-to-anti-inflammatory factor ratio in tumor tissues on overall survival in gastric cancer patients. The results showed that the IL-6/IL-10 mRNA expression ratio in tumor tissues was an independent prognostic factor for overall survival and disease-specific survival in gastric cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Min Jung Kwon, Ji Hyang Kim, Kyu Jae Kim, Eun Ju Ko, Jeong Yong Lee, Chang Su Ryu, Yong Hyun Ha, Young Ran Kim, Nam Keun Kim
Summary: Recurrent implantation failure (RIF) refers to the inability to achieve pregnancy after multiple embryo transfers. In this Korean study, the association between certain genetic variations (STAT3 rs1053004, IL-1 beta rs16944, IL-6 rs1800796, and TNF-alpha rs1800629, 1800630) and RIF prevalence was analyzed. The results showed a significant association between STAT3 rs1053004, IL-6 rs1800796, TNF-alpha rs1800629, and RIF prevalence, providing new insights into the role of inflammation in RIF.
Article
Immunology
Xiaoting Liao, Weikang Zhang, Huijun Dai, Ren Jing, Mengling Ye, Wanyun Ge, Shenglin Pei, Linghui Pan
Summary: The study found that IL-17 plays a pro-inflammatory role in ventilator-induced lung injury (VILI) and could serve as a new target for treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xue-ling Su, Shu-hui Wang, Sumra Komal, Liu-gen Cui, Rui-cong Ni, Li-rong Zhang, Sheng-na Han
Summary: In this study, the effects of caspase-1 inhibitor VX765 on the expression of Cx43 and cell-to-cell communication after myocardial infarction (MI) were investigated. The results showed that VX765 treatment significantly decreased the infarct area, alleviated cardiac dysfunction and remodeling, and raised Cx43 levels in the heart after MI. In addition, VX765 treatment reversed the downregulation of Cx43 expression and improved intercellular communication in vitro.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Anne-Catherine Dolens, Kaat Durinck, Marieke Lavaert, Joni Van der Meulen, Imke Velghe, Jelle De Medts, Karin Weening, Juliette Roels, Katrien De Mulder, Pieter-Jan Volders, Katleen De Preter, Tessa Kerre, Bart Vandekerckhove, Georges Leclercq, Jo Vandesompele, Pieter Mestdagh, Pieter Van Vlierberghe, Frank Speleman, Tom Taghon
Article
Biochemistry & Molecular Biology
Ruben Van Paemel, Andries De Koker, Christa Caggiano, Annelien Morlion, Pieter Mestdagh, Bram De Wilde, Jo Vandesompele, Katleen De Preter
Summary: The study evaluated the impact of blood collection tube type and time delay on cfDNA methylation analysis, finding that all preservation tubes performed similarly on quality metrics. A significant increase in cfDNA concentration and the fraction derived from NK cells was observed after a 72-hour time delay in EDTA tubes.
Article
Oncology
Jingwei Chen, Christopher Nelson, Matthew Wong, Andrew E. Tee, Pei Y. Liu, Ting La, Jamie I. Fletcher, Alvin Kamili, Chelsea Mayoh, Christoph Bartenhagen, Toby N. Trahair, Ning Xu, Nisitha Jayatilleke, Marie Wong, Hui Peng, Bernard Atmadibrata, Belamy B. Cheung, Qing Lan, Tracy M. Bryan, Pieter Mestdagh, Jo Vandesompele, Valerie Combaret, Valentina Boeva, Jenny Y. Wang, Isabelle Janoueix-Lerosey, Mark J. Cowley, Karen L. MacKenzie, Alla Dolnikov, Jinyan Li, Patsie Polly, Glenn M. Marshall, Roger R. Reddel, Murray D. Norris, Michelle Haber, Matthias Fischer, Xu D. Zhang, Hilda A. Pickett, Tao Liu
Summary: The combination therapy of OTX015 and carfilzomib shows synergistic anticancer effects on TERT-rearranged neuroblastoma by reducing TERT expression, inducing cell apoptosis, and suppressing tumor progression. This treatment approach is likely to be translated into the first clinical trial of targeted therapy in patients with TERT-rearranged neuroblastoma.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Liselot M. Mus, Stephane Van Haver, Mina Popovic, Wim Trypsteen, Steve Lefever, Nadja Zeltner, Yudelca Ogando, Eva Z. Jacobs, Geertrui Denecker, Ellen Sanders, Christophe Van Neste, Suzanne Vanhauwaert, Bieke Decaesteker, Dieter Deforce, Filip Van Nieuwerburgh, Pieter Mestdagh, Jo Vandesompele, Bjorn Menten, Katleen De Preter, Lorenz Studer, Bjorn Heindryckx, Kaat Durinck, Stephen Roberts, Frank Speleman
Summary: Human embryonic stem cells and embryonal tumors both exhibit compromised G1/S checkpoint, leading to replicative stress and genomic instability. Long-term in vitro cultured hESCs show a high incidence of DNA copy number gains, which may provide a proliferative advantage.
GENES CHROMOSOMES & CANCER
(2021)
Review
Oncology
Eva Hulstaert, Annelien Morlion, Keren Levanon, Jo Vandesompele, Pieter Mestdagh
Summary: This systematic review presents 75 RNA biomarkers detectable in human biofluids for early diagnosis of ovarian cancer, with the majority identified using RT-qPCR or microarrays in blood-based fluids. Some studies utilized RNA-sequencing and looked into alternative fluids like urine and ascites. Promising biomarkers include miR-21, the miR-200 family, miR-205, miR-10a, and miR-346, while validation and further research are needed before clinical implementation. Challenges in biomarker validation and future perspectives are discussed to accelerate progress in this field.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Mathieu Spaas, Nora Sundahl, Eva Hulstaert, Vibeke Kruse, Sylvie Rottey, Daan De Maeseneer, Veerle Surmont, Annabel Meireson, Lieve Brochez, Dries Reynders, Els Goetghebeur, Robbe Van den Begin, Dirk Van Gestel, Vincent Renard, Piet Dirix, Pieter Mestdagh, Piet Ost
Summary: The CHEERS trial aims to evaluate whether concurrent administration of SBRT and CPIs can prolong progression-free survival in advanced solid tumor patients. This multicenter randomized phase II trial will assess the impact of SBRT on disease control time and explore outcomes such as survival, objective response, local control, quality of life, and toxicity in 98 patients.
Article
Pathology
Pieter Mestdagh, Michel Gillard, Sharonjit K. Dhillon, Jean-Paul Pirnay, Jeroen Poels, Jan Hellemans, Veronik Hutse, Celine Vermeiren, Maxime Boutier, Veerle De Wever, Patrick Soentjens, Sarah Djebara, Hugues Malonne, Emmanuel Andre, Marc Arbyn, John Smeraglia, Jo Vandesompele
Summary: Saliva specimens have lower sensitivity in detecting SARS-CoV-2 compared to nasopharyngeal swabs, but show higher sensitivity for cases with medium to high viral loads, potentially aiding in the identification of the most contagious cases.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2021)
Correction
Biotechnology & Applied Microbiology
Lucia Lorenzi, Hua-Sheng Chiu, Francisco Avila Cobos, Stephen Gross, Pieter-Jan Volders, Robrecht Cannoodt, Justine Nuytens, Katrien Vanderheyden, Jasper Anckaert, Steve Lefever, Aidan P. Tay, Eric J. de Bony, Wim Trypsteen, Fien Gysens, Marieke Vromman, Tine Goovaerts, Thomas Birkballe Hansen, Scott Kuersten, Nele Nijs, Tom Taghon, Karim Vermaelen, Ken R. Bracke, Yvan Saeys, Tim De Meyer, Nandan P. Deshpande, Govardhan Anande, Ting-Wen Chen, Marc R. Wilkins, Ashwin Unnikrishnan, Katleen De Preter, Jorgen Kjems, Jan Koster, Gary P. Schroth, Jo Vandesompele, Pavel Sumazin, Pieter Mestdagh
NATURE BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lucia Lorenzi, Hua-Sheng Chiu, Francisco Avila Cobos, Stephen Gross, Pieter-Jan Volders, Robrecht Cannoodt, Justine Nuytens, Katrien Vanderheyden, Jasper Anckaert, Steve Lefever, Aidan P. Tay, Eric J. de Bony, Wim Trypsteen, Fien Gysens, Marieke Vromman, Tine Goovaerts, Thomas Birkballe Hansen, Scott Kuersten, Nele Nijs, Tom Taghon, Karim Vermaelen, Ken R. Bracke, Yvan Saeys, Tim De Meyer, Nandan P. Deshpande, Govardhan Anande, Ting-Wen Chen, Marc R. Wilkins, Ashwin Unnikrishnan, Katleen De Preter, Jorgen Kjems, Jan Koster, Gary P. Schroth, Jo Vandesompele, Pavel Sumazin, Pieter Mestdagh
Summary: The study identified numerous novel non-coding RNAs from 300 human tissues and cell lines, expanding the existing catalog of ncRNAs. By analyzing pre-mRNA abundance estimates from total RNA sequencing, the research revealed several microRNAs and long non-coding RNAs with potential roles in regulating protein-coding genes and pathways.
NATURE BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shanna Dewaele, Louis Delhaye, Boel De Paepe, Eric James de Bony, Jilke De Wilde, Katrien Vanderheyden, Jasper Anckaert, Nurten Yigit, Justine Nuytens, Eveline Vanden Eynde, Joel Smet, Maxime Verschoore, Fariba Nemati, Didier Decaudin, Manuel Rodrigues, Peihua Zhao, Aart Jochemsen, Eleonora Leucci, Jo Vandesompele, Jo Van Dorpe, Jean-Christophe Marine, Rudy Van Coster, Sven Eyckerman, Pieter Mestdagh
Summary: The inhibition of SAMMSON in uveal melanoma cells has shown to impair cell growth and viability, induce apoptosis, and affect protein translation levels, highlighting its potential as a therapeutic target. This study demonstrates the essential role of SAMMSON expression in uveal melanoma cell survival, suggesting ASO-mediated silencing of SAMMSON as a promising treatment strategy for both primary and metastatic uveal melanoma patients.
Article
Biochemistry & Molecular Biology
Annelien Morlion, Celine Everaert, Justine Nuytens, Eva Hulstaert, Jo Vandesompele, Pieter Mestdagh
Summary: Long non-coding RNAs (lncRNAs) are transcripts without protein coding potential that play regulatory roles in cellular processes. They have emerged as potential diagnostic and therapeutic targets, and a custom lncRNA capture sequencing approach allows for more accurate detection and higher coverage compared to traditional methods.
Article
Cell Biology
Geert A. Martens, Geert Stange, Lorenzo Piemonti, Jasper Anckaert, Zhidong Ling, Daniel G. Pipeleers, Frans K. Gorus, Pieter Mestdagh, Dieter De Smet, Jo Vandesompele, Bart Keymeulen, Sarah Roels
Summary: This study identified multiple beta cell-enriched microRNAs that are co-released with miR-375 and can be used as complementary biomarkers of beta cell death, with miR-375 and miR-132 showing potential for graft outcome.
Article
Cell Biology
Glenn Vergauwen, Joeri Tulkens, Claudio Pinheiro, Francisco Avila Cobos, Sandor Dedeyne, Marie-Angelique De Scheerder, Linos Vandekerckhove, Francis Impens, Ilkka Miinalainen, Geert Braems, Kris Gevaert, Pieter Mestdagh, Jo Vandesompele, Hannelore Denys, Olivier De Wever, An Hendrix
Summary: This study fractionated blood plasma using SEC and OptiPrep density gradient centrifugation to investigate clinical and time-dependent variations in the biomolecular landscape of systemically circulating EV. Results showed that EV carry context-dependent and/or time-dependent protein and small RNA compositions, with differential analysis providing a catalogue of proteins not associated with EV. Overall, blood plasma fractionation can advance the biological understanding and biomarker development of systemically circulating EV.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Biochemical Research Methods
Eva Hulstaert, Anneleen Decock, Annelien Morlion, Celine Everaert, Kimberly Verniers, Justine Nuytens, Nele Nijs, Gary P. Schroth, Scott Kuersten, Stephen M. Gross, Pieter Mestdagh, Jo Vandesompele
Summary: The optimized workflow described in this study addresses the challenges of analyzing extracellular RNA (exRNA) from human biofluids with low RNA concentration and compromised integrity. It includes synthetic spike-in RNA molecules as processing controls and an alternative data normalization strategy.
Article
Biochemistry & Molecular Biology
Blake A. Sweeney, Anton Petrov, Carlos E. Ribas, Robert D. Finn, Alex Bateman, Maciej Szymanski, Wojciech M. Karlowski, Stefan E. Seemann, Jan Gorodkin, Jamie J. Cannone, Robin R. Gutell, Simon Kay, Steven Marygold, Gil dos Santos, Adam Frankish, Jonathan M. Mudge, Ruth Barshir, Simon Fishilevich, Patricia P. Chan, Todd M. Lowe, Ruth Seal, Elspeth Bruford, Simona Panni, Pablo Porras, Dimitra Karagkouni, Artemis G. Hatzigeorgiou, Lina Ma, Zhang Zhang, Pieter-Jan Volders, Pieter Mestdagh, Sam Griffiths-Jones, Bastian Fromm, Kevin J. Peterson, Ioanna Kalvari, Eric P. Nawrocki, Anton S. Petrov, Shuai Weng, Philia Bouchard-Bourelle, Michelle Scott, Lauren M. Lui, David Hoksza, Ruth C. Lovering, Barbara Kramarz, Prita Mani, Sridhar Ramachandran, Zasha Weinberg
Summary: RNAcentral is a comprehensive database of non-coding RNA sequences, providing a single access point to over 18 million ncRNA sequences from diverse organisms and RNA types, as well as information on the secondary structure for over 13 million sequences. The database also includes a fast sequence similarity search tool with filtering options, making it a central data resource for the RNA community.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)
