Perspectives of long non-coding RNAs in cancer

LncVar: a database of genetic variation associated with long non-coding genes

(2016) Xiaowei Chen et al.   BIOINFORMATICS

Silence of long noncoding RNA UCA1 inhibits malignant proliferation and chemotherapy resistance to adriamycin in gastric cancer

(2016) Chao Shang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

LncRNA‐MIF, a c‐Myc‐activated long non‐coding RNA, suppresses glycolysis by promoting Fbxw7‐mediated c‐Myc degradation

(2016) Pengfei Zhang et al.   EMBO REPORTS

lincRNA-p21 inhibits invasion and metastasis of hepatocellular carcinoma through Notch signaling-induced epithelial-mesenchymal transition

(2016) Meng Jia et al.   HEPATOLOGY RESEARCH

Androgen-induced Long Noncoding RNA (lncRNA)SOCS2-AS1Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells

(2016) Aya Misawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation

(2016) Jian Zheng et al.   NATURE GENETICS

Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer

(2016) Haiyang Guo et al.   NATURE GENETICS

Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

(2016) Akihiro Fujimoto et al.   NATURE GENETICS

Role of non-coding sequence variants in cancer

(2016) Ekta Khurana et al.   NATURE REVIEWS GENETICS

Sam68 functions as a transcriptional coactivator of the p53 tumor suppressor

(2016) Naomi Li et al.   NUCLEIC ACIDS RESEARCH

Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma

(2016) Mansi A. Parasramka et al.   PHARMACOLOGY & THERAPEUTICS

An RNA matchmaker protein regulates the activity of the long noncoding RNA HOTAIR

(2016) Emily K. Meredith et al.   RNA

LncRNAs and cancer

(2016) Rui Zhang et al.   Oncology Letters

LncRNA GAS5 contributes to lymphatic metastasis in colorectal cancer

(2016) Yongbin Zheng et al.   Oncotarget

Association of genetic variants in lncRNA H19 with risk of colorectal cancer in a Chinese population

(2016) Shuwei Li et al.   Oncotarget

MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression

(2016) Yoshihiro Kawasaki et al.   Cell Reports

Editorial: Molecular Function and Regulation of Non-coding RNAs in Multifactorial Diseases

(2016) Mohammadreza Hajjari et al.   Frontiers in Genetics

lncRNA-RNA Interactions across the Human Transcriptome

(2016) Michał Wojciech Szcześniak et al.   PLoS One

Long non-coding RNA ANRIL is up-regulated in bladder cancer and regulates bladder cancer cell proliferation and apoptosis through the intrinsic pathway

(2015) Hongxue Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation

(2015) Chiu-Ling Chen et al.   BIOMATERIALS

Advances in long noncoding RNAs: identification, structure prediction and function annotation

(2015) Xingli Guo et al.   Briefings in Functional Genomics

BCYRN1, a c-MYC-activated long non-coding RNA, regulates cell metastasis of non-small-cell lung cancer

(2015) Tao Hu et al.   Cancer Cell International

Association between indel polymorphism in the promoter region of lncRNA GAS5 and the risk of hepatocellular carcinoma

(2015) Ruiyang Tao et al.   CARCINOGENESIS

The Interaction Between MiR-141 and lncRNA-H19 in Regulating Cell Proliferation and Migration in Gastric Cancer

(2015) Xiaoying Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

HULC and Linc00152 Act as Novel Biomarkers in Predicting Diagnosis of Hepatocellular Carcinoma

(2015) Jun Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

lncRNA-MIAT Regulates Microvascular Dysfunction by Functioning as a Competing Endogenous RNANovelty and Significance

(2015) Biao Yan et al.   CIRCULATION RESEARCH

MiR-141 Inhibits Gastric Cancer Proliferation by Interacting with Long Noncoding RNA MEG3 and Down-Regulating E2F3 Expression

(2015) Xiaoying Zhou et al.   DIGESTIVE DISEASES AND SCIENCES

A BRCA1-interacting lncRNA regulates homologous recombination

(2015) V. Sharma et al.   EMBO REPORTS

Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse embryonic stem cells

(2015) Jennifer Y. Tan et al.   GENOME RESEARCH

Circulating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls

(2015) Lei Dong et al.   INTERNATIONAL JOURNAL OF CANCER

Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma

(2015) Liwen Hu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression

(2015) Weizhao Peng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell apoptosis by epigenetic silencing of KLF2

(2015) Ming-de Huang et al.   Journal of Hematology & Oncology

Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression

(2015) Tetsuo Hirano et al.   Molecular Cancer

The landscape of long noncoding RNAs in the human transcriptome

(2015) Matthew K Iyer et al.   NATURE GENETICS

Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides

(2015) Kim A. Lennox et al.   NUCLEIC ACIDS RESEARCH

Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells

(2015) Antoine Tanne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes

(2015) Zhuo Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MALAT1-miR-124-RBG2 axis is involved in growth and invasion of HR-HPV-positive cervical cancer cells

(2015) Shikai Liu et al.   TUMOR BIOLOGY

Expression analysis of four long noncoding RNAs in breast cancer

(2015) Mostafa Iranpour et al.   TUMOR BIOLOGY

Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway

(2015) Feng Wang et al.   Oncotarget

Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population

(2015) Chao Yang et al.   Oncotarget

Bridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis

(2015) Sweta Sharma et al.   Scientific Reports

Transcriptome sequencing reveals thousands of novel long non-coding RNAs in B cell lymphoma

(2015) Akanksha Verma et al.   Genome Medicine

The Long Noncoding RNA MEG3 Is Downregulated and Inversely Associated with VEGF Levels in Osteoarthritis

(2015) Wei Su et al.   Biomed Research International

The Long Noncoding RNA MEG3 Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma

(2015) Jing Liu et al.   PLoS One

Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a

(2015) Er-bao Zhang et al.   Oncotarget

A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma

(2014) Ji-hang Yuan et al.   CANCER CELL

Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma

(2014) Sheng-Xian Yuan et al.   CANCER LETTERS

PCAT-1 , a Long Noncoding RNA, Regulates BRCA2 and Controls Homologous Recombination in Cancer

(2014) John R. Prensner et al.   CANCER RESEARCH

Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway

(2014) Zhengkun Li et al.   CANCER SCIENCE

Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers

(2014) W.-Q. Li et al.   CARCINOGENESIS

Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

(2014) Jian-Feng Xiang et al.   CELL RESEARCH

TGF- -Induced Upregulation of malat1 Promotes Bladder Cancer Metastasis by Associating with suz12

(2014) Y. Fan et al.   CLINICAL CANCER RESEARCH

Oncogenic Ras influences the expression of multiple lncRNAs

(2014) Yojiro Kotake et al.   CYTOTECHNOLOGY

Long non-coding RNA HOTAIR is associated with human cervical cancer progression

(2014) HEE JUNG KIM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Activation ofLTBP3Gene by a Long Noncoding RNA (lncRNA)MALAT1Transcript in Mesenchymal Stem Cells from Multiple Myeloma

(2014) Bingzong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at theKcnq1locus

(2014) He Zhang et al.   JOURNAL OF CELL BIOLOGY

Modulation of hypoxia-signaling pathways by extracellular linc-RoR

(2014) K. Takahashi et al.   JOURNAL OF CELL SCIENCE

8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia

(2014) Yoshiaki Chinen et al.   Journal of Hematology & Oncology

Long non-coding RNAs in cancer invasion and metastasis

(2014) Xiao-han Shen et al.   MODERN PATHOLOGY

Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer

(2014) Ming-zhe Ma et al.   Molecular Cancer

Long Noncoding RNA ANRIL Promotes Non-Small Cell Lung Cancer Cell Proliferation and Inhibits Apoptosis by Silencing KLF2 and P21 Expression

(2014) F.-q. Nie et al.   MOLECULAR CANCER THERAPEUTICS

Pseudogene PTENP1 Functions as a Competing Endogenous RNA to Suppress Clear-Cell Renal Cell Carcinoma Progression

(2014) G. Yu et al.   MOLECULAR CANCER THERAPEUTICS

The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites

(2014) Jason A. West et al.   MOLECULAR CELL

PVT1 dependence in cancer with MYC copy-number increase

(2014) Yuen-Yi Tseng et al.   NATURE

A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies

(2014) Jingnan Sun et al.   NUCLEIC ACIDS RESEARCH

lncRNASNP: a database of SNPs in lncRNAs and their potential functions in human and mouse

(2014) Jing Gong et al.   NUCLEIC ACIDS RESEARCH

A long noncoding RNA connects c-Myc to tumor metabolism

(2014) Chiu-Lien Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5

(2014) T. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosslinking-immunoprecipitation (iCLIP) analysis reveals global regulatory roles of hnRNP L

(2014) Oliver Rossbach et al.   RNA Biology

ncRuPAR inhibits gastric cancer progression by down-regulating protease-activated receptor-1

(2014) Long Liu et al.   TUMOR BIOLOGY

LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis

(2014) P Hou et al.   Cell Death & Disease

Conserved sequence-specific lincRNA–steroid receptor interactions drive transcriptional repression and direct cell fate

(2014) William H. Hudson et al.   Nature Communications

Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature

(2014) Yolanda Sánchez et al.   Nature Communications

Long noncoding RNAs and the genetics of cancer

(2013) S W Cheetham et al.   BRITISH JOURNAL OF CANCER

Negative regulation of lncRNA GAS5 by miR-21

(2013) Z Zhang et al.   CELL DEATH AND DIFFERENTIATION

Endogenous miRNA Sponge lincRNA-RoR Regulates Oct4, Nanog, and Sox2 in Human Embryonic Stem Cell Self-Renewal

(2013) Yue Wang et al.   DEVELOPMENTAL CELL

A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation

(2013) Guohui Wan et al.   EMBO JOURNAL

Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients

(2013) Luca Quagliata et al.   HEPATOLOGY

Large Intervening Non-Coding RNA HOTAIR is Associated with Hepatocellular Carcinoma Progression

(2013) YJ Geng et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer

(2013) Xuefei Shi et al.   MOLECULAR CARCINOGENESIS

Repression of the Long Noncoding RNA-LET by Histone Deacetylase 3 Contributes to Hypoxia-Mediated Metastasis

(2013) Fu Yang et al.   MOLECULAR CELL

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

LncRNA loc285194 is a p53-regulated tumor suppressor

(2013) Qian Liu et al.   NUCLEIC ACIDS RESEARCH

Association between lncrna PCGEM1 polymorphisms and prostate cancer risk

(2013) Y Xue et al.   PROSTATE CANCER AND PROSTATIC DISEASES

A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

(2013) S. Carpenter et al.   SCIENCE

A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells

(2013) MIN FAN et al.   Experimental and Therapeutic Medicine

The Intronic Long Noncoding RNA ANRASSF1 Recruits PRC2 to the RASSF1A Promoter, Reducing the Expression of RASSF1A and Increasing Cell Proliferation

(2013) Felipe C. Beckedorff et al.   PLoS Genetics

Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers

(2013) Alayne L Brunner et al.   GENOME BIOLOGY

Specific changes in the expression of imprinted genes in prostate cancer—implications for cancer progression and epigenetic regulation

(2012) Teodora Ribarska et al.   ASIAN JOURNAL OF ANDROLOGY

Phase 1/2a, dose-escalation, safety, pharmacokinetic and preliminary efficacy study of intratumoral administration of BC-819 in patients with unresectable pancreatic cancer

(2012) N Hanna et al.   CANCER GENE THERAPY

RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings

(2012) Shancheng Ren et al.   CELL RESEARCH

The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage

(2012) Ali Zhang et al.   CELL RESEARCH

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

(2012) T. Derrien et al.   GENOME RESEARCH

Elevation of Highly Up-regulated in Liver Cancer (HULC) by Hepatitis B Virus X Protein Promotes Hepatoma Cell Proliferation via Down-regulating p18

(2012) Yumei Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LincRNA-p21 Suppresses Target mRNA Translation

(2012) Je-Hyun Yoon et al.   MOLECULAR CELL

Control of somatic tissue differentiation by the long non-coding RNA TINCR

(2012) Markus Kretz et al.   NATURE

The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r

(2012) Andrew Keniry et al.   NATURE CELL BIOLOGY

A Genetic Variant in Long Non-Coding RNA HULC Contributes to Risk of HBV-Related Hepatocellular Carcinoma in a Chinese Population

(2012) Yao Liu et al.   PLoS One

The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type

(2012) J. Jendrzejewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The hallmarks of cancer

(2012) Tony Gutschner et al.   RNA Biology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

(2011) M. N. Cabili et al.   GENES & DEVELOPMENT

Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans

(2011) Fu Yang et al.   HEPATOLOGY

A polymorphism in the chromosome 9p21 ANRIL locus is associated to Philadelphia positive acute lymphoblastic leukemia

(2011) Ilaria Iacobucci et al.   LEUKEMIA RESEARCH

Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions

(2011) Ci Chu et al.   MOLECULAR CELL

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements

(2011) Chenguang Gong et al.   NATURE

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

(2011) Kevin C. Wang et al.   NATURE

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression

(2011) John R Prensner et al.   NATURE BIOTECHNOLOGY

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

(2011) Tiffany Hung et al.   NATURE GENETICS

Human Cancer Long Non-Coding RNA Transcriptomes

(2011) Ewan A. Gibb et al.   PLoS One

RNA splicing control

(2011) Xinying Zong et al.   RNA Biology

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

(2010) Kyoko L. Yap et al.   MOLECULAR CELL

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells

(2010) Sabine Loewer et al.   NATURE GENETICS

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution

(2010) Julian König et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

(2010) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer

(2010) Jiayi Wang et al.   NUCLEIC ACIDS RESEARCH

Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 INK4B tumor suppressor gene

(2010) Y Kotake et al.   ONCOGENE

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Noncoding RNA Gas5 Is a Growth Arrest- and Starvation-Associated Repressor of the Glucocorticoid Receptor

(2010) T. Kino et al.   Science Signaling

Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression

(2010) Michael S. Cunnington et al.   PLoS Genetics

Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer

(2009) Wing Pui Tsang et al.   CARCINOGENESIS

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma

(2008) Yuichi Nakamura et al.   CANCER GENETICS AND CYTOGENETICS

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

(2008) Xiangting Wang et al.   NATURE

The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin

(2008) T. Nagano et al.   SCIENCE