Journal
ONCOLOGY LETTERS
Volume 12, Issue 2, Pages 1233-1239Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2016.4770
Keywords
long non-coding RNA; HOTAIR; MALAT1; cancer
Categories
Funding
- National Natural Science Foundation of China [81302093, 81272752, 81573747]
- Hong Kong Scholars Program [XJ2015033]
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Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs composed of >200 nucleotides. Recent studies have revealed that lncRNAs exert an important role in the development and progression of cancer. In this review, the involvement of the most extensively investigated lncRNAs in cancers of the digestive, respiratory, reproductive, urinary and central nervous systems are discussed. LncRNAs function via molecular and biochemical mechanisms that include cis- and trans-regulation of gene expression, epigenetic modulation in the nucleus and post-transcriptional control in the cytoplasm. Although the detailed biological functions and molecular mechanisms of the majority of lncRNAs remain to be elucidated, this review aims to provide a novel insight into the diagnosis and treatment of cancer using lncRNAs.
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