Telomeres and telomerase in cancer

Syndromes of Telomere Shortening

(2009) Mary Armanios   Annual Review of Genomics and Human Genetics

Genetic p53 Deficiency Partially Rescues the Adrenocortical Dysplasia Phenotype at the Expense of Increased Tumorigenesis

(2009) Tobias Else et al.   CANCER CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Caudal regression in adrenocortical dysplasia (acd) mice is caused by telomere dysfunction with subsequent p53-dependent apoptosis

(2009) Christopher N. Vlangos et al.   DEVELOPMENTAL BIOLOGY

Human RAP1 inhibits non-homologous end joining at telomeres

(2009) Jay Sarthy et al.   EMBO JOURNAL

Dyskeratosis Congenita

(2009) Sharon A. Savage et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

A Conserved WD40 Protein Binds the Cajal Body Localization Signal of scaRNP Particles

(2009) Kazimierz T. Tycowski et al.   MOLECULAR CELL

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

(2009) Yoshiko Maida et al.   NATURE

Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice

(2009) M. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

(2009) A. S. Venteicher et al.   SCIENCE

TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita

(2008) Sharon A. Savage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes

(2008) A. J. Walne et al.   BLOOD

Understanding and exploitinghTERTpromoter regulation for diagnosis and treatment of human cancers

(2008) Satoru Kyo et al.   CANCER SCIENCE

Identification of ATPases Pontin and Reptin as Telomerase Components Essential for Holoenzyme Assembly

(2008) Andrew S. Venteicher et al.   CELL

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

(2008) Hongwu Zheng et al.   NATURE

DNA damage and ageing: new-age ideas for an age-old problem

(2008) George A. Garinis et al.   NATURE CELL BIOLOGY

TERT promotes cellular and organismal survival independently of telomerase activity

(2008) J Lee et al.   ONCOGENE

TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program

(2008) Jinkuk Choi et al.   PLoS Genetics

A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis

(2008) Shintaro Imamura et al.   PLoS One

Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells

(2008) D. T. Breault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita

(2008) T. Vulliamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Key Role for Telomerase Reverse Transcriptase Unit in Modulating Human Embryonic Stem Cell Proliferation, Cell Cycle Dynamics, and In Vitro Differentiation

(2008) Chunbo Yang et al.   STEM CELLS