Article
Oncology
Tian Liang, Tong Lu, Weiwei Jia, Runze Li, Min Jiang, Yu Jiao, Yuchen Wang, Shanshan Cong, Xinyan Jiang, Lina Dong, Yingyu Zhou, Guangmei Zhang, Dan Xiao
Summary: This study elucidated the role and downstream mechanism of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the process of pyroptosis in cervical cancer cells. The findings demonstrated that lncRNA MALAT1 was upregulated in cervical carcinoma cells and its knockdown induced pyroptosis-mediated cell death, while its overexpression blocked lipopolysaccharide-induced pyroptosis. The study also identified the involvement of the microRNA-124/sirtuin 1 axis in mediating the effects of lncRNA MALAT1 on cervical cancer cell pyroptosis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Oncology
Xiaoqiang Su, Pan Liu, Hongwei Zhao, Lixin Sun, Wuliang Wang, Shuanglin Jin, Hui Wang, Ping Liu, Chunlin Chen, Min Hao
Summary: This study aimed to investigate the differences in long-term oncological outcomes between HR-HPV negative and HR-HPV positive early-stage cervical cancers. The findings suggest that the tumor results of HR-HPV negative group and HR-HPV positive group were similar after eliminating the differences in known variables that affect the oncological outcomes of cervical cancer, indicating that the treatment plan for HR-HPV positive cervical cancer is suitable for HR-HPV negative cervical cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Tian Liang, Yuchen Wang, Yu Jiao, Shanshan Cong, Xinyan Jiang, Lina Dong, Guangmei Zhang, Dan Xiao
Summary: Emerging studies have uncovered the crucial role of LncRNA MALAT1 in promoting cervical carcinoma proliferation by regulating miR-124 as a potential target. Overexpression of miR-124 inhibits tumor growth, while knockdown of MALAT1 accelerates the progression of cervical cancer.
JOURNAL OF ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Weiping Xia, Xiang Chen, Zewu Zhu, Hequn Chen, Bingsheng Li, Kangning Wang, Li Huang, Zhi Liu, Zhi Chen
Summary: The study found that lncRNA MALAT1 promotes the process of renal interstitial fibrosis through the miR-124-3p/ITGB1 signaling pathway, suggesting its potential as a therapeutic target for RIF.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Baocheng Zhu, Hengguan Cui, Weiqiang Xu
Summary: Hydrogen gas treatment significantly inhibits proliferation and migration of gastric cancer cells, while affecting the expression of related genes, showing potential therapeutic effects. In addition, the lncRNA MALAT1/miR-124-3p/EZH2 axis may serve as an important target for intervention.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Garima Singh, Sonika Kumari Sharma, Samarendra Kumar Singh
Summary: MicroRNAs play an important role in regulating cell cycle and other cellular processes. This study reveals that miR-34a can suppress HPV E6 protein and destabilize Cdt2/DTL protein level in HPV-infected cervical cancer cells, leading to the suppression of cell proliferation, invasion and migration capabilities of these cells. The findings suggest the potential of miR-34a as a specific therapy for cervical cancer treatment.
Article
Biochemistry & Molecular Biology
Xin Geng, Shipeng Li, Jinghui Li, Renli Qi, Lianmei Zhong, Hualin Yu
Summary: This study found that MDMA promoted the expression of MALAT1 and inhibited the targeted downregulation of MEKK3 by miR-124, resulting in upregulation of MEKK3 expression and jointly promoting the progression of PD.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Suzhen Wu, Lili Liu, Huanying Xu, Qiaoling Zhu, Minhua Tan
Summary: Infection with high-risk HPV, such as types 16 and 18, is closely associated with the development of cervical cancer. Non-coding RNA, specifically MALAT1, has been found to play a role in HPV-positive cervical cancer by regulating key genes and promoting cell proliferation and metastasis. Understanding the MALAT-ALKBH5 signaling axis in HPV-positive cervical cancer cells could provide insights into tumorigenic mechanisms and potential therapeutic targets.
CANCER BIOLOGY & THERAPY
(2023)
Article
Cell Biology
Li Li, Yan Ma, Kamalibaike Maerkeya, Davuti Reyanguly, Lili Han
Summary: The up-regulation of lncRNA OIP5-AS1 in cervical cancer tissues promotes cell proliferation and enhances the Warburg effect of tumor cells under hypoxic conditions through the miR-124-5p/IDH2/HIF-1α pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Flavia M. Correa, Arn Migowski, Liz M. De Almeida, Marcelo A. Soares
Summary: This review discusses the current strategies in Brazil for screening, treatment, and prevention (HPV vaccination) against cervical cancer, highlighting the country's large public health system and the disparities in access to healthcare. It also explores the potential integration of newer technologies to eliminate cervical cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Chenyi Zhang, Lai Pan, Haizheng Zhang, Ting Ke, Yuxuan Yang, Lan Zhang, Lili Chen, Jingyi Tan
Summary: The study investigated the role of lncRNA MALAT1 and miRNA-124 in osteoclast differentiation, providing new clues for the pathogenesis of periodontitis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Neurosciences
Hongyu Cheng, Haikang Zhao, Xin Xiao, Qian Huang, Wen Zeng, Bo Tian, Tao Ma, Dan Lu, Yulong Jin, Yuqian Li
Summary: The high expression of MALAT1 in glioma is associated with poor prognosis, and its silencing inhibits tumor cell proliferation and induces apoptosis. MALAT1 regulates glioma development through the miR-124/ZEB2 pathway, providing a new potential strategy for future therapy.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Alice Avian, Nicolo Clemente, Elisabetta Mauro, Erica Isidoro, Michela Di Napoli, Sandra Dudine, Anna Del Fabro, Stefano Morini, Tiziana Perin, Fabiola Giudici, Tamara Cammisuli, Nicola Foschi, Marco Mocenigo, Michele Montrone, Chiara Modena, Martina Polenghi, Luca Puzzi, Vjekoslav Tomaic, Giulio Valenti, Riccardo Sola, Shivani Zanolla, Enea Vogrig, Elisabetta Riva, Silvia Angeletti, Massimo Ciccozzi, Santina Castriciano, Maria Pachetti, Matteo Petti, Sandro Centonze, Daniela Gerin, Lawrence Banks, Bruna Marini, Vincenzo Canzonieri, Francesco Sopracordevole, Fabrizio Zanconati, Rudy Ippodrino
Summary: According to the study, HPV Selfy, a full-genotyping HPV DNA test, meets the criteria for primary cervical cancer screening described in international guidelines and shows good performance on both clinician-collected and self-collected samples.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Shreya Desai, Michelle J. Zhu, Ilana Lapidos-Salaiz
Summary: Low- and middle-income countries bear a high burden of preventable cervical cancer cases and deaths, with human papillomavirus DNA-based testing increasingly being the preferred screening method. This commentary discusses next steps and key considerations for the expansion of this screening approach.
Article
Orthopedics
Rigbat Rozi, Yubo Zhou, Kai Rong, Pingbo Chen
Summary: This study aimed to investigate the role of miR-124-3p in chondrocyte pyroptosis and cartilage injury in osteoarthritis (OA). The results showed that overexpression of miR-124-3p could alleviate cartilage injury and inhibit chondrocyte pyroptosis. Further investigations revealed that miR-124-3p exerted its function by regulating the expression of factors such as MALAT1 and KLF5.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)