The Human Leukocyte Antigen (HLA)-B27 Peptidomein Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion

Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome

(2017) Adrian Martín-Esteban et al.   JOURNAL OF AUTOIMMUNITY

ERAAP Shapes the Peptidome Associated with Classical and Nonclassical MHC Class I Molecules

(2016) Niranjana A. Nagarajan et al.   JOURNAL OF IMMUNOLOGY

Arginine (Di)methylated Human Leukocyte Antigen Class I Peptides Are Favorably Presented by HLA-B*07

(2016) Fabio Marino et al.   JOURNAL OF PROTEOME RESEARCH

Human Leukocyte Antigen (HLA) B27 Allotype-Specific Binding and Candidate Arthritogenic Peptides Revealed through Heuristic Clustering of Data-independent Acquisition Mass Spectrometry (DIA-MS) Data

(2016) Ralf B. Schittenhelm et al.   MOLECULAR & CELLULAR PROTEOMICS

A Molecular Basis for the Presentation of Phosphorylated Peptides by HLA-B Antigens

(2016) Adán Alpízar et al.   MOLECULAR & CELLULAR PROTEOMICS

Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view

(2016) José A. López de Castro et al.   MOLECULAR IMMUNOLOGY

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

(2016) David Ellinghaus et al.   NATURE GENETICS

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Ankylosing Spondylitis and Axial Spondyloarthritis

(2016) Joel D. Taurog et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Peptidome of Behçet's Disease-Associated HLA-B*51:01 Includes Two Subpeptidomes Differentially Shaped by Endoplasmic Reticulum Aminopeptidase 1

(2016) Pablo Guasp et al.   Arthritis & Rheumatology

HLA-B27

(2015) Paul Bowness   Annual Review of Immunology

Gapped sequence alignment using artificial neural networks: application to the MHC class I system

(2015) Massimo Andreatta et al.   BIOINFORMATICS

Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease

(2015) Michael J. Ombrello et al.   CURRENT OPINION IN RHEUMATOLOGY

Endoplasmic reticulum aminopeptidase 1 and rheumatic disease

(2015) Tri M. Tran et al.   CURRENT OPINION IN RHEUMATOLOGY

The intestinal microbiome in spondyloarthritis

(2015) Tejpal Gill et al.   CURRENT OPINION IN RHEUMATOLOGY

Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen

(2015) Carlos Alvarez-Navarro et al.   MOLECULAR & CELLULAR PROTEOMICS

Analysis of Major Histocompatibility Complex (MHC) Immunopeptidomes Using Mass Spectrometry

(2015) Etienne Caron et al.   MOLECULAR & CELLULAR PROTEOMICS

Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis

(2015) Dominique Baeten et al.   NEW ENGLAND JOURNAL OF MEDICINE

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis: Fig. 1

(2015) Tony J. Kenna et al.   RHEUMATOLOGY

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

(2015) Adrian Cortes et al.   Nature Communications

IL-23 Responsive Innate-Like T Cells in Spondyloarthritis: the Less Frequent They Are, the More Vital They Appear

(2015) Koen Venken et al.   Current Rheumatology Reports

Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

(2015) Paul E Chappell et al.   eLife

Dominant Role of the ERAP1 Polymorphism R528K in Shaping the HLA-B27 Peptidome Through Differential Processing Determined by Multiple Peptide Residues

(2015) Alejandro Sanz-Bravo et al.   Arthritis & Rheumatology

ERAP1Gene Expression Is Influenced by Nonsynonymous Polymorphisms Associated With Predisposition to Spondyloarthritis

(2015) Félicie Costantino et al.   Arthritis & Rheumatology

Revisiting the Arthritogenic Peptide Theory: Quantitative Not Qualitative Changes in the Peptide Repertoire of HLA-B27 Allotypes

(2015) Ralf B. Schittenhelm et al.   Arthritis & Rheumatology

The interleukin-23/interleukin-17 immune axis as a promising new target in the treatment of spondyloarthritis

(2014) Nataliya Yeremenko et al.   CURRENT OPINION IN RHEUMATOLOGY

Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases

(2014) N Agrawal et al.   GENES AND IMMUNITY

ERAP1 in the pathogenesis of ankylosing spondylitis

(2014) Emma Reeves et al.   IMMUNOLOGIC RESEARCH

HLA-B27, but Not HLA-B7, Immunodominance to Influenza Is ERAP Dependent

(2014) A. Akram et al.   JOURNAL OF IMMUNOLOGY

Peptide Handling by HLA-B27 Subtypes Influences Their Biological Behavior, Association with Ankylosing Spondylitis and Susceptibility to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)

(2014) Noel García-Medel et al.   MOLECULAR & CELLULAR PROTEOMICS

HLA-B27 and Human β2-Microglobulin Affect the Gut Microbiota of Transgenic Rats

(2014) Phoebe Lin et al.   PLoS One

Expanding the detectable HLA peptide repertoire using electron-transfer/higher-energy collision dissociation (EThcD)

(2014) G. P. M. Mommen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nature and extent of contributions by defective ribosome products to the HLA peptidome

(2014) D. Bourdetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionally distinctERAP1allotype combinations distinguish individuals with Ankylosing Spondylitis

(2014) Emma Reeves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum aminopeptidase 1 function and its pathogenic role in regulating innate and adaptive immunity in cancer and major histocompatibility complex class I-associated autoimmune diseases

(2014) D. Fruci et al.   TISSUE ANTIGENS

Monocyte-derived dendritic cells from HLA-B27+ axial spondyloarthritis (SpA) patients display altered functional capacity and deregulated gene expression

(2014) Alice Talpin et al.   ARTHRITIS RESEARCH & THERAPY

Increased Production of Interleukin-17 Over Interleukin-10 by Treg Cells Implicates Inducible Costimulator Molecule in Experimental Spondyloarthritis

(2014) Luiza M. Araujo et al.   Arthritis & Rheumatology

HLA-B27 Subtype Oligomerization and Intracellular Accumulation Patterns Correlate With Predisposition to Spondyloarthritis

(2014) Cindy Jeanty et al.   Arthritis & Rheumatology

Expression of aberrant HLA-B27 molecules is dependent on B27 dosage and peptide supply

(2013) Kirsty McHugh et al.   ANNALS OF THE RHEUMATIC DISEASES

Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens

(2013) Sergey S. Seregin et al.   AUTOIMMUNITY

ERAP1 in ankylosing spondylitis

(2013) Carlos Alvarez-Navarro et al.   CURRENT OPINION IN RHEUMATOLOGY

Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses

(2013) Charles T. Spencer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural HLA-B*2705 Protein Ligands with Glutamine as Anchor Motif

(2013) Susana Infantes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naturally Occurring ERAP1 Haplotypes Encode Functionally Distinct Alleles with Fine Substrate Specificity

(2013) E. Reeves et al.   JOURNAL OF IMMUNOLOGY

The Effect of Proteasome Inhibition on the Generation of the Human Leukocyte Antigen (HLA) Peptidome

(2013) Elena Milner et al.   MOLECULAR & CELLULAR PROTEOMICS

HLA-B27 misfolding and ankylosing spondylitis

(2013) Robert A. Colbert et al.   MOLECULAR IMMUNOLOGY

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

(2013) Adrian Cortes et al.   NATURE GENETICS

Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA-B27

(2013) Liye Chen et al.   Arthritis & Rheumatology

Review: The Interleukin-23/Interleukin-17 Axis in Spondyloarthritis Pathogenesis: Th17 and Beyond

(2013) Judith A. Smith et al.   Arthritis & Rheumatology

Reverse Interferon Signature Is Characteristic of Antigen-Presenting Cells in Human and Rat Spondyloarthritis

(2013) Ingrid Fert et al.   Arthritis & Rheumatology

Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis

(2012) Nigil Haroon et al.   ANNALS OF THE RHEUMATIC DISEASES

Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats

(2012) Joel D. Taurog et al.   ARTHRITIS AND RHEUMATISM

Relationship between inflammation, bone destruction, and osteoproliferation in the HLA-B27/human β2-microglobulin-transgenic rat model of spondylarthritis

(2012) Leonie M. van Duivenvoorde et al.   ARTHRITIS AND RHEUMATISM

The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function

(2012) Jia-huai Wang et al.   IMMUNOLOGICAL REVIEWS

The Energetic Basis Underpinning T-cell Receptor Recognition of a Super-bulged Peptide Bound to a Major Histocompatibility Complex Class I Molecule

(2012) Yu Chih Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Association with ERAP1 in Psoriasis Is Confined to Disease Onset after Puberty and Not Dependent on HLA-C*06

(2012) Josefin Lysell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Functional Interaction of the Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 Polymorphism and HLA-B27in Vivo

(2012) Noel García-Medel et al.   MOLECULAR & CELLULAR PROTEOMICS

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells

(2012) Jonathan P Sherlock et al.   NATURE MEDICINE

ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis

(2012) Chin-Man Wang et al.   ARTHRITIS RESEARCH & THERAPY

Origin and plasticity of MHC I-associated self peptides

(2011) Danielle de Verteuil et al.   AUTOIMMUNITY REVIEWS

The Crystal Structure of Human Endoplasmic Reticulum Aminopeptidase 2 Reveals the Atomic Basis for Distinct Roles in Antigen Processing

(2011) James R. Birtley et al.   BIOCHEMISTRY

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

(2011) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

(2011) Tina T Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

(2011) G. Kochan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1

(2011) Amit Gandhi et al.   Scientific Reports

Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing Defines the Composition and Structure of MHC Class I Peptide Repertoire in Normal and Virus-Infected Cells

(2010) N. Blanchard et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

(2010) John D Reveille et al.   NATURE GENETICS

Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action

(2010) A. Lev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble plasma HLA peptidome as a potential source for cancer biomarkers

(2010) M. Bassani-Sternberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and genetic analyses of HLA class I molecules using monoclonal xenoantibodies

(2010) NAJET REBAÏ et al.   TISSUE ANTIGENS

Spondylarthritis in HLA-B27/human β2-microglobulin-transgenic rats is not prevented by lack of CD8

(2009) Joel D. Taurog et al.   ARTHRITIS AND RHEUMATISM

Investigating the genetic association between ERAP1 and ankylosing spondylitis

(2009) David Harvey et al.   HUMAN MOLECULAR GENETICS

The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum

(2009) A. Hearn et al.   JOURNAL OF IMMUNOLOGY

Folding of HLA–B27 subtypes is determined by the global effect of polymorphic residues and shows incomplete correspondence to ankylosing spondylitis

(2008) Begoña Galocha et al.   ARTHRITIS AND RHEUMATISM

HLA class I supertypes: a revised and updated classification

(2008) John Sidney et al.   BMC IMMUNOLOGY

Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies

(2008) Richard Apps et al.   IMMUNOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

The Internal Sequence of the Peptide-Substrate Determines Its N-Terminus Trimming by ERAP1

(2008) Irini Evnouchidou et al.   PLoS One