IL-23 Responsive Innate-Like T Cells in Spondyloarthritis: the Less Frequent They Are, the More Vital They Appear

Integrating the pathogenesis of spondyloarthritis

(2015) Katelijne De Wilde et al.   CURRENT OPINION IN RHEUMATOLOGY

Commensal microbiota influence systemic autoimmune responses

(2015) J. T. Van Praet et al.   EMBO JOURNAL

Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial

(2014) Christopher Ritchlin et al.   ANNALS OF THE RHEUMATIC DISEASES

Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS)

(2014) Denis Poddubnyy et al.   ANNALS OF THE RHEUMATIC DISEASES

The interleukin-23/interleukin-17 immune axis as a promising new target in the treatment of spondyloarthritis

(2014) Nataliya Yeremenko et al.   CURRENT OPINION IN RHEUMATOLOGY

The Identification of the Endogenous Ligands of Natural Killer T Cells Reveals the Presence of Mammalian α-Linked Glycosylceramides

(2014) Lisa Kain et al.   IMMUNITY

A178: Development of Tools to Facilitate Shared Decision Making about Medications for Juvenile Idiopathic Arthritis-A Project of the Pediatric Rheumatology Care and Outcomes Improvement Network

(2014) Esi Morgan DeWitt et al.   Arthritis & Rheumatology

The Concept of Axial Spondyloarthritis: Joint Statement of the Spondyloarthritis Research and Treatment Network and the Assessment of SpondyloArthritis international Society in Response to the US Food and Drug Administration's Comments and Concerns

(2014) Atul Deodhar et al.   Arthritis & Rheumatology

Interleukin-23 Mediates the Intestinal Response to Microbial β-1,3-Glucan and the Development of Spondyloarthritis Pathology in SKG Mice

(2014) Helen Benham et al.   Arthritis & Rheumatology

Autoantibodies against CD74 in spondyloarthritis

(2013) N T Baerlecken et al.   ANNALS OF THE RHEUMATIC DISEASES

Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-α production by interaction with its soluble E-cadherin ligand in chronically inflamed joints

(2013) Lode Melis et al.   ANNALS OF THE RHEUMATIC DISEASES

Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation

(2013) Francesco Ciccia et al.   ANNALS OF THE RHEUMATIC DISEASES

Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells

(2013) Peggy Jacques et al.   ANNALS OF THE RHEUMATIC DISEASES

Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from 5 years of follow-up

(2013) K.A. Papp et al.   BRITISH JOURNAL OF DERMATOLOGY

Natural Killer T cell obsession with self-antigens

(2013) Laurent Gapin et al.   CURRENT OPINION IN IMMUNOLOGY

Th17 cell development: from the cradle to the grave

(2013) Luis A. Zúñiga et al.   IMMUNOLOGICAL REVIEWS

Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF-  and IL-1 

(2013) M. Monteiro et al.   JOURNAL OF IMMUNOLOGY

Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial

(2013) Iain B McInnes et al.   LANCET

Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial

(2013) Dominique Baeten et al.   LANCET

Inflammatory pathways in spondyloarthritis

(2013) Hulda S. Hreggvidsdottir et al.   MOLECULAR IMMUNOLOGY

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

(2013) Adrian Cortes et al.   NATURE GENETICS

Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells

(2013) You Jeong Lee et al.   NATURE IMMUNOLOGY

How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy

(2013) Georg Schett et al.   NATURE MEDICINE

Association Between Life Events and Rheumatoid Arthritis: Results From a Population-Based Case-Control Study

(2013) Annmarie Wesley et al.   ARTHRITIS CARE & RESEARCH

Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model

(2012) Liesbet Van Praet et al.   ANNALS OF THE RHEUMATIC DISEASES

Mo2083 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 827 in Subjects With Moderate to Severe Crohn's Disease

(2012) Stephan R. Targan et al.   GASTROENTEROLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Enhanced Peptide Identification by Electron Transfer Dissociation Using an Improved Mascot Percolator

(2012) James C. Wright et al.   MOLECULAR & CELLULAR PROTEOMICS

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells

(2012) Jonathan P Sherlock et al.   NATURE MEDICINE

Genetics of spondyloarthritis—beyond the MHC

(2012) John D. Reveille   Nature Reviews Rheumatology

Invariant natural killer T cells as sensors and managers of inflammation

(2012) Luc Van Kaer et al.   TRENDS IN IMMUNOLOGY

Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive γ/δ T cells in patients with active ankylosing spondylitis

(2011) Tony J. Kenna et al.   ARTHRITIS AND RHEUMATISM

Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection

(2011) Manfred Brigl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proinflammatory Environment Dictates the IL-17-Producing Capacity of Human Invariant NKT Cells

(2011) L. Moreira-Teixeira et al.   JOURNAL OF IMMUNOLOGY

Th17 Cells Expressing KIR3DL2+ and Responsive to HLA-B27 Homodimers Are Increased in Ankylosing Spondylitis

(2011) P. Bowness et al.   JOURNAL OF IMMUNOLOGY

The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans

(2011) Paola Di Meglio et al.   PLoS One

Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses

(2011) R. Sarin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Assessment of SpondyloArthritis international Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general

(2010) M. Rudwaleit et al.   ANNALS OF THE RHEUMATIC DISEASES

Invariant natural killer T cells are natural regulators of murine spondylarthritis

(2010) Peggy Jacques et al.   ARTHRITIS AND RHEUMATISM

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

γδ T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism

(2010) Franziska Petermann et al.   IMMUNITY

Invariant natural killer T cells in rheumatic disease: a joint dilemma

(2010) Michael B. Drennan et al.   Nature Reviews Rheumatology

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

(2010) Jane C. Goodall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis

(2009) L. Melis et al.   ANNALS OF THE RHEUMATIC DISEASES

HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats

(2009) Monica L. DeLay et al.   ARTHRITIS AND RHEUMATISM

Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis

(2009) Francesco Ciccia et al.   ARTHRITIS AND RHEUMATISM

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells

(2009) Amit Awasthi et al.   JOURNAL OF IMMUNOLOGY

CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets

(2009) Julie C Ribot et al.   NATURE IMMUNOLOGY

Joint expedition: linking gut inflammation to arthritis

(2008) P Jacques et al.   Mucosal Immunology

Critical role of ROR- t in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation

(2008) M.-L. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population

(2008) J. M. Coquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA