Endoplasmic reticulum aminopeptidase 1 function and its pathogenic role in regulating innate and adaptive immunity in cancer and major histocompatibility complex class I-associated autoimmune diseases

ABC transporters in adaptive immunity

(2015) Fabian Seyffer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

ERAP1–ERAP2 Dimerization Increases Peptide-Trimming Efficiency

(2014) Irini Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Influence of the HLA characteristics of Italian patients on donor search outcome in unrelated hematopoietic stem cell transplantation

(2014) M. Testi et al.   TISSUE ANTIGENS

Deletion of the activating NKG2C receptor and a functional polymorphism in its ligand HLA-E in psoriasis susceptibility

(2013) Xue Zeng et al.   EXPERIMENTAL DERMATOLOGY

NKG2C, HLA-E and their association with psoriasis

(2013) Forum Patel et al.   EXPERIMENTAL DERMATOLOGY

Induction of Protective Antitumor Immunity through Attenuation of ERAAP Function

(2013) E. James et al.   JOURNAL OF IMMUNOLOGY

Naturally Occurring ERAP1 Haplotypes Encode Functionally Distinct Alleles with Fine Substrate Specificity

(2013) E. Reeves et al.   JOURNAL OF IMMUNOLOGY

ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases

(2013) Carlos Alvarez-Navarro et al.   MOLECULAR IMMUNOLOGY

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

(2013) E. Zervoudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MHC I loading complex: a multitasking machinery in adaptive immunity

(2013) Sabine Hulpke et al.   TRENDS IN BIOCHEMICAL SCIENCES

p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1

(2013) Bei Wang et al.   Nature Communications

Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA-B27

(2013) Liye Chen et al.   Arthritis & Rheumatology

The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies

(2012) Alessandra Fierabracci et al.   AUTOIMMUNITY REVIEWS

Exon 10 Coding Sequence Is Important for Endoplasmic Reticulum Retention of Endoplasmic Reticulum Aminopeptidase 1

(2012) Akira Hattori et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Role of Endoplasmic Reticulum Aminopeptidases in Health and Disease: from Infection to Cancer

(2012) Loredana Cifaldi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nonclassical MHC class Ib–restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum

(2012) Niranjana A Nagarajan et al.   NATURE IMMUNOLOGY

IRF1 and NF-kB Restore MHC Class I-Restricted Tumor Antigen Processing and Presentation to Cytotoxic T Cells in Aggressive Neuroblastoma

(2012) Silvia Lorenzi et al.   PLoS One

Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease

(2012) Haoyan Chen et al.   PLoS Genetics

Natural Killer Cells Efficiently Reject Lymphoma Silenced for the Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing

(2011) L. Cifaldi et al.   CANCER RESEARCH

Post-proteasomal and proteasome-independent generation of MHC class I ligands

(2011) Peter van Endert   CELLULAR AND MOLECULAR LIFE SCIENCES

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

(2011) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B

(2011) Julian P. Vivian et al.   NATURE

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1

(2011) Sungchul Kim et al.   NATURE IMMUNOLOGY

NF- B, and not MYCN, Regulates MHC Class I and Endoplasmic Reticulum Aminopeptidases in Human Neuroblastoma Cells

(2010) M. Forloni et al.   CANCER RESEARCH

Contribution of functional KIR3DL1 to ankylosing spondylitis

(2010) Ivan V Zvyagin et al.   Cellular & Molecular Immunology

Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing Defines the Composition and Structure of MHC Class I Peptide Repertoire in Normal and Virus-Infected Cells

(2010) N. Blanchard et al.   JOURNAL OF IMMUNOLOGY

Association analyses identify six new psoriasis susceptibility loci in the Chinese population

(2010) Liang-Dan Sun et al.   NATURE GENETICS

Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation

(2010) Aida M. Andrés et al.   PLoS Genetics

Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma

(2009) Akash M. Mehta et al.   GENES CHROMOSOMES & CANCER

Multiple Loci within the Major Histocompatibility Complex Confer Risk of Psoriasis

(2009) Bing-Jian Feng et al.   PLoS Genetics

Coping with loss of perfection in the MHC class I peptide repertoire

(2008) Nicolas Blanchard et al.   CURRENT OPINION IN IMMUNOLOGY

Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non‐lymphoid human tissues

(2008) Doriana Fruci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Polymorphisms of KIRs Gene and HLA-C Alleles in Patients with Ankylosing Spondylitis: Possible Association with Susceptibility to the Disease

(2008) Yu-Lian Jiao et al.   JOURNAL OF CLINICAL IMMUNOLOGY

CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence

(2008) Emma J. Petrie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Subtle Changes in Peptide Conformation Profoundly Affect Recognition of the Non-Classical MHC Class I Molecule HLA-E by the CD94–NKG2 Natural Killer Cell Receptors

(2008) Hilary L. Hoare et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for NKG2A/CD94 recognition of HLA-E

(2008) B. K. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HLA alleles determine differences in human natural killer cell responsiveness and potency

(2008) S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris

(2008) M. Jobim et al.   TISSUE ANTIGENS