Functional Interaction of the Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 Polymorphism and HLA-B27in Vivo

Characterizing the N-Terminal Processing Motif of MHC Class I Ligands

(2014) M. M. Schatz et al.   JOURNAL OF IMMUNOLOGY

Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis

(2012) Nigil Haroon et al.   ANNALS OF THE RHEUMATIC DISEASES

A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing

(2012) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

The Role of Insulin-Regulated Aminopeptidase in MHC Class I Antigen Presentation

(2012) Loredana Saveanu et al.   Frontiers in Immunology

The Crystal Structure of Human Endoplasmic Reticulum Aminopeptidase 2 Reveals the Atomic Basis for Distinct Roles in Antigen Processing

(2011) James R. Birtley et al.   BIOCHEMISTRY

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

(2011) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

(2011) Tina T Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters

(2011) B. N. Manz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

(2011) G. Kochan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERAP1 polymorphisms and haplotypes are associated with ankylosing spondylitis susceptibility and functional severity in a Spanish population

(2011) Magdalena Szczypiorska et al.   RHEUMATOLOGY

Mutational Analysis Reveals a Complex Interplay of Peptide Binding and Multiple Biological Features of HLA-B27

(2010) Begoña Galocha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Placental Leucine Aminopeptidase Efficiently Generates Mature Antigenic Peptides In Vitro but in Patterns Distinct from Endoplasmic Reticulum Aminopeptidase 1

(2010) D. Georgiadou et al.   JOURNAL OF IMMUNOLOGY

Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis

(2009) W. P. Maksymowych et al.   ARTHRITIS AND RHEUMATISM

Investigating the genetic association between ERAP1 and ankylosing spondylitis

(2009) David Harvey et al.   HUMAN MOLECULAR GENETICS

The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum

(2009) A. Hearn et al.   JOURNAL OF IMMUNOLOGY

IRAP Identifies an Endosomal Compartment Required for MHC Class I Cross-Presentation

(2009) L. Saveanu et al.   SCIENCE

Disparate folding and stability of the ankylosing spondylitis-associated HLA-B*1403 and B*2705 proteins

(2008) Elena Merino et al.   ARTHRITIS AND RHEUMATISM

The Internal Sequence of the Peptide-Substrate Determines Its N-Terminus Trimming by ERAP1

(2008) Irini Evnouchidou et al.   PLoS One

Peptides: the cornerstone of HLA-B27 biology and pathogenetic role in spondyloarthritis

(2008) M. Marcilla et al.   TISSUE ANTIGENS