Dominant Role of the ERAP1 Polymorphism R528K in Shaping the HLA-B27 Peptidome Through Differential Processing Determined by Multiple Peptide Residues

Peptide Handling by HLA-B27 Subtypes Influences Their Biological Behavior, Association with Ankylosing Spondylitis and Susceptibility to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)

(2014) Noel García-Medel et al.   MOLECULAR & CELLULAR PROTEOMICS

Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens

(2013) Sergey S. Seregin et al.   AUTOIMMUNITY

Co-expression of HLA-B7 and HLA-B27 alleles is associated with B7-restricted immunodominant responses following influenza infection

(2013) Ali Akram et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Combined Effects of Ankylosing Spondylitis-associated ERAP1 Polymorphisms Outside the Catalytic and Peptide-binding Sites on the Processing of Natural HLA-B27 Ligands

(2013) Adrian Martín-Esteban et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Protective Antitumor Immunity through Attenuation of ERAAP Function

(2013) E. James et al.   JOURNAL OF IMMUNOLOGY

Naturally Occurring ERAP1 Haplotypes Encode Functionally Distinct Alleles with Fine Substrate Specificity

(2013) E. Reeves et al.   JOURNAL OF IMMUNOLOGY

ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases

(2013) Carlos Alvarez-Navarro et al.   MOLECULAR IMMUNOLOGY

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

(2013) Adrian Cortes et al.   NATURE GENETICS

Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA-B27

(2013) Liye Chen et al.   Arthritis & Rheumatology

Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis

(2012) Nigil Haroon et al.   ANNALS OF THE RHEUMATIC DISEASES

Functional Interaction of the Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 Polymorphism and HLA-B27in Vivo

(2012) Noel García-Medel et al.   MOLECULAR & CELLULAR PROTEOMICS

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

(2011) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

The Origin of Proteasome-inhibitor Resistant HLA Class I Peptidomes: a Study With HLA-A*68:01

(2011) Noel García-Medel et al.   MOLECULAR & CELLULAR PROTEOMICS

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

(2011) Tina T Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters

(2011) B. N. Manz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

(2011) G. Kochan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation

(2010) Aida M. Andrés et al.   PLoS Genetics

Investigating the genetic association between ERAP1 and ankylosing spondylitis

(2009) David Harvey et al.   HUMAN MOLECULAR GENETICS

The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum

(2009) A. Hearn et al.   JOURNAL OF IMMUNOLOGY

The Internal Sequence of the Peptide-Substrate Determines Its N-Terminus Trimming by ERAP1

(2008) Irini Evnouchidou et al.   PLoS One

Peptides: the cornerstone of HLA-B27 biology and pathogenetic role in spondyloarthritis

(2008) M. Marcilla et al.   TISSUE ANTIGENS