Effects of melatonin on fatty liver disease: The role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy

Lipid oxidation products in the pathogenesis of non-alcoholic steatohepatitis

(2017) Francesco Bellanti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma

(2017) Shibo Lin et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice

(2017) Nabanita Das et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARγ/FUNDC1/mitophagy pathways

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Mff‐Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS‐Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation‐Involved mPTP Opening

(2017) Hao Zhou et al.   Journal of the American Heart Association

Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury

(2017) Hao Zhou et al.   Redox Biology

Mitochondria-meditated pathways of organ failure upon inflammation

(2017) Andrey V. Kozlov et al.   Redox Biology

Mitochondrial composition and function under the control of hypoxia

(2017) Dominik C. Fuhrmann et al.   Redox Biology

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity

(2016) Marc J. Tol et al.   DIABETES

Redox regulation of autophagy in skeletal muscle

(2016) George G. Rodney et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond

(2016) Baris Bingol et al.   FREE RADICAL BIOLOGY AND MEDICINE

Liraglutide protects cardiac microvascular endothelial cells against hypoxia/reoxygenation injury through the suppression of the SR-Ca2+–XO–ROS axis via activation of the GLP-1R/PI3K/Akt/survivin pathways

(2016) Ying Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Roles of RNA-Binding Proteins in DNA Damage Response

(2016) Mihoko Kai   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis

(2016) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria

(2016) Shangcheng Xu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin pretreatment enhances the therapeutic effects of exogenous mitochondria against hepatic ischemia-reperfusion injury in rats through suppression of mitochondrial permeability transition

(2016) Hong-Hwa Chen et al.   JOURNAL OF PINEAL RESEARCH

Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

(2016) Néstor Prieto-Domínguez et al.   JOURNAL OF PINEAL RESEARCH

Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network

(2016) María E. Díaz-Casado et al.   JOURNAL OF PINEAL RESEARCH

Melatonin enhances mitochondrial ATP synthesis, reduces reactive oxygen species formation, and mediates translocation of the nuclear erythroid 2-related factor 2 resulting in activation of phase-2 antioxidant enzymes (γ-GCS, HO-1, NQO1) in ultraviolet rad

(2016) Konrad Kleszczyński et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reduces endoplasmic reticulum stress and autophagy in liver of leptin-deficient mice

(2016) Beatriz de Luxán-Delgado et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

On the significance of an alternate pathway of melatonin synthesis via 5-methoxytryptamine: comparisons across species

(2016) Dun-Xian Tan et al.   JOURNAL OF PINEAL RESEARCH

The nuclear melatonin receptor RORαis a novel endogenous defender against myocardial ischemia/reperfusion injury

(2016) Ben He et al.   JOURNAL OF PINEAL RESEARCH

Melatonin improves non-alcoholic fatty liver disease via MAPK-JNK/P38 signaling in high-fat-diet-induced obese mice

(2016) Hang Sun et al.   Lipids in Health and Disease

Metabolic syndrome update

(2016) Scott M. Grundy   TRENDS IN CARDIOVASCULAR MEDICINE

Effects of high fat diets on rodent liver bioenergetics and oxidative imbalance

(2016) Pâmela A. Kakimoto et al.   Redox Biology

The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies

(2016) Catalina Carrasco-Pozo et al.   Redox Biology

The methyl donor S -adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease

(2016) Adrienne L. King et al.   Redox Biology

Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase

(2016) Ryan J. Mailloux et al.   Redox Biology

Curcumin inhibits activation of TRPM2 channels in rat hepatocytes

(2016) E. Kheradpezhouh et al.   Redox Biology

Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

(2016) Kuo Du et al.   Redox Biology

Interplay between oxidant species and energy metabolism

(2016) Celia Quijano et al.   Redox Biology

Melatonin ameliorates ER stress-mediated hepatic steatosis through miR-23a in the liver

(2015) Seung-Jae Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell death decision by p53 via control of the mitochondrial membrane

(2015) Nurmaa Dashzeveg et al.   CANCER LETTERS

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

(2015) Balasubramanian Krishnamurthy et al.   DIABETES

Enhancement of Hypothalamic STAT3 Acetylation by Nuclear Receptor Nur77 Dictates Leptin Sensitivity

(2015) Yan Chen et al.   DIABETES

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy

(2015) Rui Guo et al.   JOURNAL OF HEPATOLOGY

Melatonin nephroprotective action in Zucker diabetic fatty rats involves its inhibitory effect on NADPH oxidase

(2015) Katarzyna Winiarska et al.   JOURNAL OF PINEAL RESEARCH

Role of toll-like receptor 4 in melatonin-induced cardioprotection

(2015) Frederic Nduhirabandi et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

Exendin-4 enhances the migration of adipose-derived stem cells to neonatal rat ventricular cardiomyocyte-derived conditioned medium via the phosphoinositide 3-kinase/Akt-stromal cell-derived factor-1α/CXC chemokine receptor 4 pathway

(2015) HAO ZHOU et al.   Molecular Medicine Reports

Non-genomic effects of the NR4A1/Nur77/TR3/NGFIB orphan nuclear receptor

(2015) Alicja Pawlak et al.   STEROIDS

Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase

(2015) Amarjit Mishra et al.   Nature Communications

Mitochondrial dynamics and mitochondrial quality control

(2015) Hong-Min Ni et al.   Redox Biology

Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit

(2015) Derek S. Woods et al.   PLoS One

p53 Mediates Autophagy and Cell Death by a Mechanism Contingent On Bnip3

(2013) Erika Yan Wang et al.   HYPERTENSION

Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction

(2013) Asli F. Ceylan-Isik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

BNip3 Regulates Mitochondrial Function and Lipid Metabolism in the Liver

(2012) D. Glick et al.   MOLECULAR AND CELLULAR BIOLOGY

p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death

(2011) Xi Feng et al.   EMBO JOURNAL

Orphan Receptor TR3 Enhances p53 Transactivation and Represses DNA Double-Strand Break Repair in Hepatoma Cells under Ionizing Radiation

(2011) Bi-xing Zhao et al.   MOLECULAR ENDOCRINOLOGY

A Short Nur77-Derived Peptide Converts Bcl-2 from a Protector to a Killer

(2008) Siva Kumar Kolluri et al.   CANCER CELL

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL