Promoter methylation and age-related downregulation of Klotho in rhesus monkey

Distinct DNA methylation changes highly correlated with chronological age in the human brain

(2011) Dena G. Hernandez et al.   HUMAN MOLECULAR GENETICS

Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer

(2011) Jie Pan et al.   TUMOR BIOLOGY

Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549

(2010) Bo Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Progressive age-dependent DNA methylation changes start before adulthood in mouse tissues

(2010) Masaki Takasugi   MECHANISMS OF AGEING AND DEVELOPMENT

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

(2010) Jaehyouk Lee et al.   Molecular Cancer

Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility

(2010) Tura C. Camilli et al.   Pigment Cell & Melanoma Research

Klotho and aging

(2009) Makoto Kuro-o   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect

(2009) Laura Invidia et al.   BIOGERONTOLOGY

Effects of normal aging on prefrontal area 46 in the rhesus monkey

(2009) Jennifer Luebke et al.   BRAIN RESEARCH REVIEWS

Epigenetic Control of MicroRNA Expression and Aging

(2009) Ruqiang Liang et al.   CURRENT GENOMICS

Transcriptional activation of the human Klotho gene by epidermal growth factor in HEK293 cells; role of Egr-1

(2009) Byeong Hyeok Choi et al.   GENE

Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin

(2009) I Wolf et al.   ONCOGENE

The effects of normal aging on myelinated nerve fibers in monkey central nervous system

(2009) Alan Peters   Frontiers in Neuroanatomy

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

(2009) Brock C. Christensen et al.   PLoS Genetics

The discovery of α-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis

(2008) Y. Nabeshima   CELLULAR AND MOLECULAR LIFE SCIENCES

Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory

(2008) F. D. Lubin et al.   JOURNAL OF NEUROSCIENCE

DNA double-strand breaks: A potential causative factor for mammalian aging?

(2008) Han Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Murine microRNAs implicated in liver functions and aging process

(2008) Olivier C. Maes et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice

(2008) M. Shiozaki et al.   NEUROSCIENCE

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

(2008) I Wolf et al.   ONCOGENE

A translocation causing increased  -Klotho level results in hypophosphatemic rickets and hyperparathyroidism

(2008) C. A. Brownstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-dependent accumulation of ubiquitinated 2′,3′-cyclic nucleotide 3′-phosphodiesterase in myelin lipid rafts

(2007) Jason D. Hinman et al.   GLIA

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey

(2007) James A. Duce et al.   GLIA

An MRI study of age-related white and gray matter volume changes in the rhesus monkey

(2007) Jonathan J. Wisco et al.   NEUROBIOLOGY OF AGING

DNA methylation impacts on learning and memory in aging

(2007) Liang Liu et al.   NEUROBIOLOGY OF AGING