Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics

SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice

(2016) Sokrates Stein et al.   Aging-US

The NADPH Oxidase Nox4 and Aging in the Heart

(2016) Tetsuro Ago et al.   Aging-US

Autophagy in endothelial progenitor cells is cytoprotective in hypoxic conditions

(2012) Hai-Jie Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Enhancement of 26S Proteasome Functionality Connects Oxidative Stress and Vascular Endothelial Inflammatory Response in Diabetes Mellitus

(2012) Hongtao Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Staying cool in difficult times: Mitochondrial dynamics, quality control and the stress response

(2012) Timothy E. Shutt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy

(2012) Riccardo Calvani et al.   BIOLOGICAL CHEMISTRY

The shape of things to come: mitochondrial fusion and fission in the adult heart

(2012) A. R. Hall et al.   CARDIOVASCULAR RESEARCH

Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload

(2012) Jerome Piquereau et al.   CARDIOVASCULAR RESEARCH

Autophagy and cardiovascular aging

(2012) Sreejayan Nair et al.   CELL CYCLE

Mitochondria and Cardiovascular Aging

(2012) Dao-Fu Dai et al.   CIRCULATION RESEARCH

Contribution of Impaired Mitochondrial Autophagy to Cardiac Aging

(2012) Debapriya Dutta et al.   CIRCULATION RESEARCH

Insulin-Like Growth Factor 1 Alleviates High-Fat Diet–Induced Myocardial Contractile Dysfunction

(2012) Yingmei Zhang et al.   HYPERTENSION

Translational evidence that impaired autophagy contributes to arterial ageing

(2012) Thomas J. LaRocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Diverse Roles of Growth Hormone and Insulin-Like Growth Factor-1 in Mammalian Aging: Progress and Controversies

(2012) W. E. Sonntag et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Circulating Factors Induced by Caloric Restriction in the Nonhuman Primate Macaca Mulatta Activate Angiogenic Processes in Endothelial Cells

(2012) A. Csiszar et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Emerging Role of IGF-1 Deficiency in Cardiovascular Aging: Recent Advances

(2012) Z. Ungvari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Age-Associated Proinflammatory Secretory Phenotype in Vascular Smooth Muscle Cells From the Non-human Primate Macaca mulatta: Reversal by Resveratrol Treatment

(2012) A. Csiszar et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Vitamin K2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency

(2012) M. Vos et al.   SCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Cerebrovascular Disease and Mechanisms of Cognitive Impairment

(2012) Raj N. Kalaria   STROKE

The neurobiology of sirtuins and their role in neurodegeneration

(2012) Gizem Donmez   TRENDS IN PHARMACOLOGICAL SCIENCES

Mitochondrial network energetics in the heart

(2012) Miguel A. Aon et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Caloric restriction: powerful protection for the aging heart and vasculature

(2011) Edward P. Weiss et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response

(2011) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death

(2011) Kyriakos N. Papanicolaou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol in cardiovascular health and disease

(2011) Goran Petrovski et al.   Annals of the New York Academy of Sciences

Insulin-like growth factor-1 receptor activation prevents hydrogen peroxide-induced oxidative stress, mitochondrial dysfunction and apoptosis

(2011) Chang-Ning Hao et al.   APOPTOSIS

Mitochondrial Oxidative Stress in Aortic Stiffening With Age

(2011) Rui-Hai Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of randomized controlled trials

(2011) Linggen Gao et al.   ATHEROSCLEROSIS

A comprehensive glossary of autophagy-related molecules and processes (2ndedition)

(2011) Daniel J Klionsky et al.   Autophagy

Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis

(2011) Seon-Jin Lee et al.   Autophagy

AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy

(2011) Zhonglin Xie et al.   Autophagy

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

(2011) Dao-Fu Dai et al.   CIRCULATION RESEARCH

Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis

(2011) Yun Chen et al.   CIRCULATION RESEARCH

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

The role of free radical generation in increasing cerebrovascular permeability

(2011) Paul A. Fraser   FREE RADICAL BIOLOGY AND MEDICINE

Caloric Restriction Ameliorates Angiotensin II–Induced Mitochondrial Remodeling and Cardiac Hypertrophy

(2011) Piet Finckenberg et al.   HYPERTENSION

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

Parkin Interacts with Ambra1 to Induce Mitophagy

(2011) C. Van Humbeeck et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

(2011) Dao-Fu Dai et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Age-Associated Vascular Oxidative Stress, Nrf2 Dysfunction, and NF- B Activation in the Nonhuman Primate Macaca mulatta

(2011) Z. Ungvari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-Induced Permeability Transition in Cardiac Myocytes

(2011) K. N. Papanicolaou et al.   MOLECULAR AND CELLULAR BIOLOGY

Caloric restriction

(2011) John R. Speakman et al.   MOLECULAR ASPECTS OF MEDICINE

Image-based genome-wide siRNA screen identifies selective autophagy factors

(2011) Anthony Orvedahl et al.   NATURE

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Vascular Contributions to Cognitive Impairment and Dementia

(2011) Philip B. Gorelick et al.   STROKE

AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction

(2010) Subat Turdi et al.   AGING CELL

Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria

(2010) Dao-Fu Dai et al.   AGING CELL

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

(2010) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Development of Mitochondria-targeted Aromatic-cationic Peptides for Neurodegenerative Diseases

(2010) Hazel H. Szeto   Annals of the New York Academy of Sciences

Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells

(2010) Raquel S. Carreira et al.   Autophagy

Inhibition of autophagy in the heart induces age-related cardiomyopathy

(2010) Manabu Taneike et al.   Autophagy

What are the sources of hydrogen peroxide production by heart mitochondria?

(2010) Vera G. Grivennikova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Neuroprotective properties of resveratrol in different neurodegenerative disorders

(2010) Diego Albani et al.   BIOFACTORS

Mitochondrial morphology and cardiovascular disease

(2010) S.-B. Ong et al.   CARDIOVASCULAR RESEARCH

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Intramyocardial VEGF-B 167 Gene Delivery Delays the Progression Towards Congestive Failure in Dogs With Pacing-Induced Dilated Cardiomyopathy

(2010) Martino Pepe et al.   CIRCULATION RESEARCH

Oxidative Stress and Endothelial Dysfunction in Cardiovascular Disease: Mitochondria-Targeted Therapeutics

(2010) M. Rocha et al.   CURRENT MEDICINAL CHEMISTRY

Chaperone-mediated autophagy in protein quality control

(2010) Esperanza Arias et al.   CURRENT OPINION IN CELL BIOLOGY

Arterial aging: a journey into subclinical arterial disease

(2010) Mingyi Wang et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes

(2010) A. Makino et al.   DIABETOLOGIA

Does calorie restriction induce mitochondrial biogenesis? A reevaluation

(2010) Chad R. Hancock et al.   FASEB JOURNAL

Mitochondrial impairment contributes to cocaine-induced cardiac dysfunction: Prevention by the targeted antioxidant MitoQ

(2010) Aurélia Vergeade et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Impact of long-term caloric restriction on cardiac senescence: Caloric restriction ameliorates cardiac diastolic dysfunction associated with aging

(2010) Ken Shinmura et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondria and aging in the vascular system

(2010) Zoltan Ungvari et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mechanisms of Vascular Aging: New Perspectives

(2010) Z. Ungvari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Life-long caloric restriction elicits pronounced protection of the aged myocardium: A role for AMPK

(2010) Andrew G. Edwards et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Cardiac Aging in Mice and Humans: The Role of Mitochondrial Oxidative Stress

(2010) Dao-Fu Dai et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Resveratrol induces mitochondrial biogenesis in endothelial cells

(2009) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial-derived hydrogen peroxide inhibits relaxation of bovine coronary arterial smooth muscle to hypoxia through stimulation of ERK MAP kinase

(2009) Qun Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells

(2009) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging

(2009) Mary L. Modrick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

MitoQ administration prevents endotoxin-induced cardiac dysfunction

(2009) G. S. Supinski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Alzheimer Disease–Associated Peptide, Amyloid β40, Inhibits Vascular Regeneration With Induction of Endothelial Autophagy

(2009) Shin-ichiro Hayashi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Emerging roles of mitochondrial membrane dynamics in health and disease

(2009) Anja Schäfer et al.   BIOLOGICAL CHEMISTRY

Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway

(2009) Narasimman Gurusamy et al.   CARDIOVASCULAR RESEARCH

Mitochondrial OPA1, apoptosis, and heart failure

(2009) Le Chen et al.   CARDIOVASCULAR RESEARCH

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Metformin Prevents Progression of Heart Failure in Dogs

(2009) Hideyuki Sasaki et al.   CIRCULATION

Heart Disease and Stroke Statistics—2009 Update

(2009) et al.   CIRCULATION

Suppression of Phosphoinositide 3-Kinase Prevents Cardiac Aging in Mice

(2009) Yasutaka Inuzuka et al.   CIRCULATION

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

(2009) Dao-Fu Dai et al.   CIRCULATION

Antioxidant, EUK-8, Prevents Murine Dilated Cardiomyopathy

(2009) Satoru Kawakami et al.   CIRCULATION JOURNAL

Cellular Mechanisms of Cardioprotection by Calorie Restriction: State of the Science and Future Perspectives

(2009) Emanuele Marzetti et al.   CLINICS IN GERIATRIC MEDICINE

Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   FASEB JOURNAL

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

(2009) Delyth Graham et al.   HYPERTENSION

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1

(2009) Anna Csiszar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Mitochondrial protein homeostasis: the cooperative roles of chaperones and proteases

(2009) Wolfgang Voos   RESEARCH IN MICROBIOLOGY

Resveratrol preserves cerebrovascular density and cognitive function in aging mice

(2009) Charlotte Oomen   Frontiers in Aging Neuroscience

Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats

(2008) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

(2008) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ultrastructure of the Mitochondrion and Its Bearing on Function and Bioenergetics

(2008) Giovanni Benard et al.   ANTIOXIDANTS & REDOX SIGNALING

Studies of the human aortic intima by a direct quantitative assay of mutant alleles in the mitochondrial genome

(2008) M. Sazonova et al.   ATHEROSCLEROSIS

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

(2008) Gilad Twig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

(2008) Tianzheng Yu et al.   CARDIOVASCULAR RESEARCH

Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction

(2008) Philip Wenzel et al.   CARDIOVASCULAR RESEARCH

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Antioxidant Gene Therapy for Cardiovascular Disease

(2008) Anna-Liisa Levonen et al.   CIRCULATION

Mechanisms Underlying Caloric Restriction and Lifespan Regulation

(2008) Zoltan Ungvari et al.   CIRCULATION RESEARCH

Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

(2008) Susheel Gundewar et al.   CIRCULATION RESEARCH

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Low Doses of Insulin-Like Growth Factor-I Induce Mitochondrial Protection in Aging Rats

(2008) Juan E. Puche et al.   ENDOCRINOLOGY

Mitochondrial biogenesis and healthy aging

(2008) Guillermo López-Lluch et al.   EXPERIMENTAL GERONTOLOGY

Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart

(2008) J.L. Barger et al.   EXPERIMENTAL GERONTOLOGY

The role of p66Shc deletion in age-associated arterial dysfunction and disease states

(2008) Giovanni G. Camici et al.   JOURNAL OF APPLIED PHYSIOLOGY

Vascular endothelial senescence: from mechanisms to pathophysiology

(2008) Jorge D. Erusalimsky   JOURNAL OF APPLIED PHYSIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

(2008) Jamie L. Barger et al.   PLoS One

Increased Aortic Calpain-1 Activity Mediates Age-Associated Angiotensin II Signaling of Vascular Smooth Muscle Cells

(2008) Liqun Jiang et al.   PLoS One

Mitochondria-Targeted Cytoprotective Peptides for Ischemia–Reperfusion Injury

(2007) Hazel H. Szeto   ANTIOXIDANTS & REDOX SIGNALING

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING