Ageing, metabolism and cardiovascular disease

The life-extending effect of dietary restriction requires Foxo3 in mice

(2015) Isao Shimokawa et al.   AGING CELL

Forkhead Box O-1 Modulation Improves Endothelial Insulin Resistance in Human Obesity

(2015) S. Karki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transcriptional and epigenetic regulation of autophagy in aging

(2015) Louis R Lapierre et al.   Autophagy

Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging

(2015) Olivier R. Baris et al.   Cell Metabolism

Targeting Chromatin Remodeling to Prevent Cardiovascular Disease in Diabetes

(2015) Sarah Costantino et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

(2015) Stephan Winnik et al.   EUROPEAN HEART JOURNAL

Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial

(2015) S. Vigili de Kreutzenberg et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction

(2015) Thomas A. Csepe et al.   Frontiers in Physiology

Association study ofFOXO3ASNPs and aging phenotypes in Danish oldest-old individuals

(2014) Mette Soerensen et al.   AGING CELL

p66Shc-induced redox changes drive endothelial insulin resistance

(2014) Francesco Paneni et al.   ATHEROSCLEROSIS

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells

(2014) X Yu et al.   CELL DEATH AND DIFFERENTIATION

Cardiovascular disease in Europe 2014: epidemiological update

(2014) Melanie Nichols et al.   EUROPEAN HEART JOURNAL

Metformin Plays a Dual Role in MIN6 Pancreatic β Cell Function through AMPK-dependent Autophagy

(2014) Yingling Jiang et al.   International Journal of Biological Sciences

Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart

(2014) Thomas K. Sin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK

(2014) Anne Marie Thompson et al.   PLoS One

FOXO transcription factors: key regulators of cellular quality control

(2014) Ashley E. Webb et al.   TRENDS IN BIOCHEMICAL SCIENCES

AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner

(2014) Matthew Ulgherait et al.   Cell Reports

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis

(2013) Anthony M. J. Sanchez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dietary Curcumin Ameliorates Aging-Related Cerebrovascular Dysfunction through the AMPK/Uncoupling Protein 2 Pathway

(2013) Yunfei Pu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Deletion of the Activated Protein-1 Transcription Factor JunD Induces Oxidative Stress and Accelerates Age-Related Endothelial Dysfunction

(2013) Francesco Paneni et al.   CIRCULATION

Proinflammatory Endothelial Activation Detected by Molecular Imaging in Obese Nonhuman Primates Coincides With Onset of Insulin Resistance and Progressively Increases With Duration of Insulin Resistance

(2013) Scott M. Chadderdon et al.   CIRCULATION

SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory: Bringing All the Strands Together

(2013) F. Paneni et al.   DIABETES

Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease

(2012) Dao-Fu Dai et al.   ANTIOXIDANTS & REDOX SIGNALING

Blockade of the Nuclear Factor-κB Pathway in the Endothelium Prevents Insulin Resistance and Prolongs Life Spans

(2012) Yutaka Hasegawa et al.   CIRCULATION

The Assessment of Endothelial Function

(2012) Andreas J. Flammer et al.   CIRCULATION

Protein Kinase C-β Contributes to Impaired Endothelial Insulin Signaling in Humans With Diabetes Mellitus

(2012) Corey E. Tabit et al.   CIRCULATION

p66 Shc as the Engine of Vascular Aging

(2012) Francesco Paneni et al.   Current Vascular Pharmacology

Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism

(2012) Lisa A. Lesniewski et al.   MECHANISMS OF AGEING AND DEVELOPMENT

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease

(2011) Fabian C. Franzeck et al.   ATHEROSCLEROSIS

AMPK induces vascular smooth muscle cell senescence via LKB1 dependent pathway

(2011) Jin Young Sung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A review of the cost of cardiovascular disease

(2011) Jean-Eric Tarride et al.   CANADIAN JOURNAL OF CARDIOLOGY

Protective roles of SIRT1 in atherosclerosis

(2011) Sokrates Stein et al.   CELL CYCLE

Endothelium-Dependent Delivery of Insulin to Muscle Interstitium

(2011) Christian Rask-Madsen et al.   Cell Metabolism

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Cellular Senescence, Vascular Disease, and Aging

(2011) Jason C. Kovacic et al.   CIRCULATION

Forecasting the Future of Cardiovascular Disease in the United States

(2011) Paul A. Heidenreich et al.   CIRCULATION

Aging and vascular endothelial function in humans

(2011) Douglas R. Seals et al.   CLINICAL SCIENCE

The cardioprotective effects of metformin

(2011) Saloua El Messaoudi et al.   CURRENT OPINION IN LIPIDOLOGY

The effects of the dietary polyphenol resveratrol on human healthy aging and lifespan

(2011) Agustín F. Fernández et al.   Epigenetics

miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells

(2011) Gabriel Eades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy

(2011) Nagalingam R. Sundaresan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways

(2010) Gian Paolo Fadini et al.   AGING CELL

The FoxO Family in Cardiac Function and Dysfunction

(2010) Sarah M. Ronnebaum et al.   Annual Review of Physiology

Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome?

(2010) Jean-Louis Beaudeux et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Vascular aging: From molecular mechanism to clinical significance

(2010) Motoji Sawabe   Geriatrics & Gerontology International

Fibrosis and Cardiac Arrhythmias

(2010) Sanne de Jong et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Arterial aging—hemodynamic changes and therapeutic options

(2010) Michel E. Safar   Nature Reviews Cardiology

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

MicroRNA 217 Modulates Endothelial Cell Senescence via Silent Information Regulator 1

(2009) Rossella Menghini et al.   CIRCULATION

Gene Therapy Targeting Nuclear Factor-κB: Towards Clinical Application in Inflammatory Diseases and Cancer

(2009) Sander Tas et al.   CURRENT GENE THERAPY

Oxidative Stress Contributes to Aging by Enhancing Pancreatic Angiogenesis and Insulin Signaling

(2008) Gaëlle Laurent et al.   Cell Metabolism

FoxO transcription factors in the maintenance of cellular homeostasis during aging

(2008) Dervis AM Salih et al.   CURRENT OPINION IN CELL BIOLOGY

The role of p66Shc deletion in age-associated arterial dysfunction and disease states

(2008) Giovanni G. Camici et al.   JOURNAL OF APPLIED PHYSIOLOGY

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

(2008) Ina Berniakovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY