BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells

BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex

(2012) Shinji Kawai et al.   JOURNAL OF CELL BIOLOGY

Integration of BRCA1-mediated miRNA and mRNA profiles reveals microRNA regulation of TRAF2 and NFκB pathway

(2011) Miljana Tanic et al.   BREAST CANCER RESEARCH AND TREATMENT

The effect of various vitamin D supplementation regimens in breast cancer patients

(2011) Luke J. Peppone et al.   BREAST CANCER RESEARCH AND TREATMENT

Loss of A-type lamins and genomic instability

(2011) Ignacio Gonzalez-Suarez et al.   CELL CYCLE

Regulating the levels of key factors in cell cycle and DNA repair: New pathways revealed by lamins

(2011) Abena B. Redwood et al.   CELL CYCLE

A dual role for A-type lamins in DNA double-strand break repair

(2011) Abena B. Redwood et al.   CELL CYCLE

Oncogenic Ras Regulates BRIP1 Expression to Induce Dissociation of BRCA1 from Chromatin, Inhibit DNA Repair, and Promote Senescence

(2011) Zhigang Tu et al.   DEVELOPMENTAL CELL

A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair

(2011) Ignacio Gonzalez-Suarez et al.   EMBO JOURNAL

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

(2011) Quan Zhu et al.   NATURE

BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability

(2011) A. Aly et al.   Journal of Molecular Cell Biology

Poly(ADP-Ribose) Polymerase Inhibitors

(2010) Elaina M. Gartner et al.   CANCER JOURNAL

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

BRCA1 affects global DNA methylation through regulation of DNMT1

(2010) Vivek Shukla et al.   CELL RESEARCH

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

(2010) Anne Bothmer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic Potential of Poly(ADP-ribose) Polymerase Inhibitor AG014699 in Human Cancers With Mutated or Methylated BRCA1 or BRCA2

(2010) Yvette Drew et al.   JNCI-Journal of the National Cancer Institute

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

(2009) Silvia ρlvarez-Díaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Cathepsin L, target in cancer treatment?

(2009) Jacqueline M. Lankelma et al.   LIFE SCIENCES

A Selective Requirement for 53BP1 in the Biological Response to Genomic Instability Induced by Brca1 Deficiency

(2009) Liu Cao et al.   MOLECULAR CELL

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation

(2008) Elizabeth M. Duncan et al.   CELL

Prolactin Blocks Nuclear Translocation of VDR by Regulating Its Interaction with BRCA1 in Osteosarcoma Cells

(2008) Changhui Deng et al.   MOLECULAR ENDOCRINOLOGY