Updates on immunity and inflammation in Parkinson disease pathology

Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases

(2017) Scott T. Brady et al.   NEUROBIOLOGY OF DISEASE

Neurodegenerative signaling factors and mechanisms in Parkinson's pathology

(2017) Poonam Goswami et al.   TOXICOLOGY IN VITRO

Modulation of Microglial Activity by Rho-Kinase (ROCK) Inhibition as Therapeutic Strategy in Parkinson’s Disease and Amyotrophic Lateral Sclerosis

(2017) Anna-Elisa Roser et al.   Frontiers in Aging Neuroscience

Increased Levels of Pro-Inflammatory and Anti-Inflammatory Cellular Responses in Parkinson’s Disease Patients: Search for a Disease Indicator

(2017) Likun Yang et al.   MEDICAL SCIENCE MONITOR

PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease

(2017) Francois Mouton-Liger et al.   Frontiers in Molecular Neuroscience

Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T α-synuclein by activating the JNK 1/Bcl-2/beclin 1 pathway

(2016) Feng-Tao Liu et al.   BRAIN RESEARCH

Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease

(2016) Goutam Chandra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model

(2016) Noemie Tentillier et al.   JOURNAL OF NEUROSCIENCE

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Removal of regulatory T cells prevents secondary chronic infection but increases the mortality of subsequent sub-acute infection in sepsis mice

(2016) Ruichao Huo et al.   Oncotarget

CD200 Inhibits Inflammatory Response by Promoting KATP Channel Opening in Microglia Cells in Parkinson’s Disease

(2016) Yi Ren et al.   MEDICAL SCIENCE MONITOR

Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in autoimmune, neurological and psychiatric diseases

(2015) M. Levite   Acta Physiologica

The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?

(2015) Kevin R. Doty et al.   BRAIN RESEARCH

Current disease modifying approaches to treat Parkinson’s disease

(2015) Dan Lindholm et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Role of Neuroinflammation in Dementias

(2015) Giuseppe Pasqualetti et al.   Current Neurology and Neuroscience Reports

Inhibition of Rho-kinase by Fasudil protects dopamine neurons and attenuates inflammatory response in an intranasal lipopolysaccharide-mediated Parkinson's model

(2015) Qing He et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Antagonistic pleiotropic effects of nitric oxide in the pathophysiology of Parkinson's disease

(2015) D. Tripathy et al.   FREE RADICAL RESEARCH

Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson's disease

(2015) Ting-ting Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

(2015) Madison T Gray et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms

(2015) Yumao Jiang et al.   JOURNAL OF ETHNOPHARMACOLOGY

A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders

(2015) Howard E. Gendelman et al.   Journal of Neuroimmune Pharmacology

Efficacy and safety profile of prolonged release oxycodone in combination with naloxone (OXN PR) in Parkinson’s disease patients with chronic pain

(2015) Graziella Madeo et al.   JOURNAL OF NEUROLOGY

Multitarget intervention of Fasudil in the neuroprotection of dopaminergic neurons in MPTP-mouse model of Parkinson's disease

(2015) Yong-fei Zhao et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The role of quercetin on the survival of neuron-like PC12 cells and the expression of α-synuclein

(2015) BeomS Jeon et al.   Neural Regeneration Research

The relation between α-synuclein and microglia in Parkinson’s disease: Recent developments

(2015) V. Sanchez-Guajardo et al.   NEUROSCIENCE

Low-dose aspirin (acetylsalicylate) prevents increases in brain PGE2, 15-epi-lipoxin A4 and 8-isoprostane concentrations in 9 month-old HIV-1 transgenic rats, a model for HIV-1 associated neurocognitive disorders

(2015) Helene C. Blanchard et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

(2015) Douglas G. Walker et al.   Alzheimers Research & Therapy

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Anti-apoptotic and Anti-oxidative Roles of Quercetin After Traumatic Brain Injury

(2014) Tao Yang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP+-induced oxidative stress and cell death in SH-SY5Y cells

(2014) Cheong-Meng Chong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Renoprotective, anti-oxidative and anti-apoptotic effects of oral low-dose quercetin in the C57BL/6J model of diabetic nephropathy

(2014) Isabele BS Gomes et al.   Lipids in Health and Disease

HSP60 is involved in the neuroprotective effects of naloxone

(2014) WENJING CHENG et al.   Molecular Medicine Reports

Inhibition of the microglial response is essential for the neuroprotective effects of Rho-kinase inhibitors on MPTP-induced dopaminergic cell death

(2014) Ana Borrajo et al.   NEUROPHARMACOLOGY

Rho Kinase and Dopaminergic Degeneration

(2014) Jose L. Labandeira-Garcia et al.   NEUROSCIENTIST

Potential neuroprotective effect of ibuprofen, insights from the mice model of Parkinson's disease

(2014) Maciej Świątkiewicz et al.   Pharmacological Reports

Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease

(2014) Ricardo Cabezas et al.   Frontiers in Cellular Neuroscience

Evidence of Inflammatory System Involvement in Parkinson’s Disease

(2014) Yinxia Chao et al.   Biomed Research International

The majority of newly generated cells in the adult mouse substantia nigra express low levels of Doublecortin, but their proliferation is unaffected by 6-OHDA-induced nigral lesion or Minocycline-mediated inhibition of neuroinflammation

(2013) Maik M. A. Worlitzer et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Immune Privilege as an Intrinsic CNS Property: Astrocytes Protect the CNS against T-Cell-Mediated Neuroinflammation

(2013) Ulrike Gimsa et al.   MEDIATORS OF INFLAMMATION

Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion-Like Disorder?

(2013) C. Warren Olanow et al.   MOVEMENT DISORDERS

Inhibition of Rho kinase mediates the neuroprotective effects of estrogen in the MPTP model of Parkinson's disease

(2013) Ana I. Rodriguez-Perez et al.   NEUROBIOLOGY OF DISEASE

Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson’s disease in rats

(2013) S.S. Karuppagounder et al.   NEUROSCIENCE

Enhanced Prostacyclin Synthesis by Adenoviral Gene Transfer Reduced Glial Activation and Ameliorated Dopaminergic Dysfunction in Hemiparkinsonian Rats

(2013) May-Jywan Tsai et al.   Oxidative Medicine and Cellular Longevity

Microglial Cells Are Involved in the Susceptibility of NADPH Oxidase Knockout Mice to 6-Hydroxy-Dopamine-Induced Neurodegeneration

(2013) Marina S. Hernandes et al.   PLoS One

Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease

(2013) Jason R. Richardson et al.   NEURAL PLASTICITY

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

(2012) L. Tonges et al.   BRAIN

Glia as a Turning Point in the Therapeutic Strategy of Parkinsons Disease

(2012) Francesca L'Episcopo et al.   CNS & Neurological Disorders-Drug Targets

Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases

(2012) Tomohiro Nakamura et al.   EXPERIMENTAL NEUROLOGY

Emerging analgesic drugs for Parkinson's disease

(2012) Santiago Perez-Lloret et al.   EXPERT OPINION ON EMERGING DRUGS

Autoimmunity, dendritic cells and relevance for Parkinson’s disease

(2012) E. Koutsilieri et al.   JOURNAL OF NEURAL TRANSMISSION

Immune Heterogeneity in Neuroinflammation: Dendritic Cells in the Brain

(2012) Carol A. Colton   Journal of Neuroimmune Pharmacology

Involvement of the mitochondrial apoptotic pathway and nitric oxide synthase in dopaminergic neuronal death induced by 6-hydroxydopamine and lipopolysaccharide

(2012) Sarika Singh et al.   REDOX REPORT

Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models

(2011) Robert Kleemann et al.   ATHEROSCLEROSIS

NSAID use and risk of Parkinson disease: a population-based case-control study

(2011) C. Becker et al.   EUROPEAN JOURNAL OF NEUROLOGY

IGF-I receptor signaling pathway is involved in the neuroprotective effect of genistein in the neuroblastoma SK-N-SH cells

(2011) Quan-Gui Gao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Impaired CD200–CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: Roles of aging, superoxide, NADPH oxidase, and p38 MAPK

(2011) Xi-Jin Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Astrocytes and Microglia: Responses to Neuropathological Conditions

(2011) Sarika Singh et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Antioxidant treatment with quercetin ameliorates erectile dysfunction in streptozotocin-induced diabetic rats

(2011) Wei Zhang et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain

(2011) Niroshana Anandasabapathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

(2011) Yvonne Couch et al.   Journal of Neuroinflammation

Glia: Initiators and progressors of pathology in Parkinson's disease

(2011) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Parkinson's disease and immunological abnormalities: increase of HLA-DR expression on monocytes in cerebrospinal fluid and of CD45RO+ T cells in peripheral blood

(2010) U. Fiszer et al.   ACTA NEUROLOGICA SCANDINAVICA

An Association between Immunosenescence and CD4+CD25+ Regulatory T cells: A Systematic Review

(2010) Ling WANG et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Salicylic acid protects against chronic l-DOPA-induced 6-OHDA generation in experimental model of parkinsonism

(2010) Anupom Borah et al.   BRAIN RESEARCH

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

(2010) Ashley D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Risk for Parkinson's disease among patients with osteoarthritis: A Danish cohort study

(2010) Kathrine Rugbjerg et al.   MOVEMENT DISORDERS

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

Role of glial cells in neurotoxin-induced animal models of Parkinson’s disease

(2010) Hironori Yokoyama et al.   NEUROLOGICAL SCIENCES

Anti-inflammatory drugs and risk of Parkinson disease: A meta-analysis

(2010) J. J. Gagne et al.   NEUROLOGY

Minocycline as a potential therapeutic agent in neurodegenerative disorders characterized by protein misfolding

(2010) Wendy Noble et al.   Prion

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

(2010) Xing-Long Gu et al.   Molecular Brain

Circulating interleukin-10 and interleukin-12 in Parkinson’s disease

(2009) M. Rentzos et al.   ACTA NEUROLOGICA SCANDINAVICA

Innate and Adaptive Immunity for the Pathobiology of Parkinson's Disease

(2009) David K. Stone et al.   ANTIOXIDANTS & REDOX SIGNALING

Time-dependent alterations of peripheral immune parameters after nigrostriatal dopamine depletion in a rat model of Parkinson’s disease

(2009) Harald Engler et al.   BRAIN BEHAVIOR AND IMMUNITY

Nitrated  -Synuclein-Induced Alterations in Microglial Immunity Are Regulated by CD4+ T Cell Subsets

(2009) A. D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Increased serum levels of soluble tumor necrosis factor-α receptor-1 in patients with Parkinson's disease

(2009) Paula Scalzo et al.   JOURNAL OF NEUROIMMUNOLOGY

Proteomic Studies of Nitrated Alpha-Synuclein Microglia Regulation by CD4+CD25+ T Cells

(2009) Ashley D. Reynolds et al.   JOURNAL OF PROTEOME RESEARCH

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Peripheral Chemo-Cytokine Profiles in Alzheimers and Parkinsons Diseases

(2009) M. Reale et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Altered Regulation of CD200 Receptor in Monocyte-Derived Macrophages from Individuals with Parkinson’s Disease

(2009) Xiao-Guang Luo et al.   NEUROCHEMICAL RESEARCH

Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity

(2009) Xiaomin Su et al.   NEUROTOXICITY RESEARCH

Protective effect of cyclooxygenase (COX)-inhibitors against drug-induced catatonia and MPTP-induced striatal lesions in rats

(2009) Amit Gupta et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Peripheral cytokines profile in Parkinson’s disease

(2008) M. Reale et al.   BRAIN BEHAVIOR AND IMMUNITY

Nonsteroidal Anti-Inflammatory Drugs in Experimental Parkinsonian Models and Parkinsons Disease

(2008) Masato Asanuma et al.   CURRENT PHARMACEUTICAL DESIGN

Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: A retrospective cohort study

(2008) Mahyar Etminan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Oxidative and Inflammatory Pathways in Parkinson’s Disease

(2008) Rebecca L. Miller et al.   NEUROCHEMICAL RESEARCH

Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFα, and INFγ concentrations are elevated in patients with atypical and idiopathic parkinsonism

(2008) Bogdan Brodacki et al.   NEUROSCIENCE LETTERS

Serum inflammatory biomarkers in Parkinson's disease

(2008) M. Dufek et al.   PARKINSONISM & RELATED DISORDERS

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

(2007) Maryse Letiembre et al.   NEUROBIOLOGY OF AGING