Review
Pharmacology & Pharmacy
Zhengyao Cai, Suxin Yuan, Yi Zhong, Li Deng, Jiafu Li, Xiaoqiu Tan, Jian Feng
Summary: Diabetes eventually leads to chronic vascular complications, with TGR5 potentially serving as a novel therapeutic target for diabetes-associated endothelial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tatsuya Maruhashi, Yukihito Higashi
Summary: Endothelial dysfunction is crucial in the progression of atherosclerosis and is significantly associated with diabetes mellitus and oxidative stress. Selecting appropriate therapeutic interventions that improve endothelial function is important for preventing diabetic vascular complications. Various hypoglycemic drugs and agents like GLP-1 receptor agonists and SGLT2 inhibitors may improve endothelial function through multiple mechanisms independent of glucose control or insulin signaling.
Review
Biochemistry & Molecular Biology
Doaa R. R. Adam, Manal M. M. Alem
Summary: Erectile dysfunction is a global public health concern associated with cardiovascular risk factors, and is considered a clinical marker for future adverse events.
Article
Biochemistry & Molecular Biology
Yan Zhou, Yuehan Wang, Chi Teng Vong, Yanyan Zhu, Baojun Xu, Cheng-Chao Ruan, Yitao Wang, Wai San Cheang
Summary: JAT has vasoprotective effects in diabetes and obesity by enhancing the Akt/eNOS pathway and NO bioavailability, as well as suppressing ER stress and oxidative stress to improve endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Yanfei Feng, Tianhao Shi, Yuli Fu, Bodong Lv
Summary: Diabetic erectile dysfunction (DED) is a common complication of diabetes mellitus, but current therapeutics have limited effectiveness. Traditional Chinese medicine (TCM) has shown promise in treating DED by targeting multiple signaling pathways. However, more research is needed to fully understand the underlying mechanisms and conduct large-scale clinical trials.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yan Zhou, Chunxiu Zhou, Xutao Zhang, Chi Teng Vong, Yitao Wang, Wai San Cheang
Summary: The study showed that coptisine can improve vascular function in diabetic patients by suppressing ER stress and oxidative stress, enhancing endothelium-dependent relaxation, indicating the therapeutic potential of coptisine for treating diabetic vasculopathy.
Article
Biochemistry & Molecular Biology
Javier Saenz-Medina, Maria Martinez, Silvia Rosado, Manuel Duran, Dolores Prieto, Joaquin Carballido
Summary: The study aimed to investigate the endothelial vascular function in patients with urolithiasis in relation to systemic inflammatory, oxidative stress, and vascular function serum markers. It found that endothelial dysfunction is an important disorder in urolithiasis patients and may be related to future cardiovascular events, although no significant association was found between inflammatory, oxidative stress, endothelial serum markers, and flow-mediated dilation.
Review
Biochemistry & Molecular Biology
Gianmaria Salvio, Alessandro Ciarloni, Melissa Cutini, Giancarlo Balercia
Summary: Erectile Dysfunction (ED) is linked to cardiovascular conditions, with hyperhomocysteinemia playing a central role in causing endothelial damage and affecting male sexual function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Adriana Leandro, Marcelo Queiroz, Lara Azul, Raquel Seica, Cristina M. Sena
Summary: The study demonstrates that omentin-1 has a positive impact on endothelial function and PVAT in non-obese type 2 diabetes mellitus animals, improving vascular relaxation, reducing oxidative stress, enhancing PVAT anti-contractile action, and alleviating pro-inflammatory status.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Biochemistry & Molecular Biology
Naris Thengchaisri, Lih Kuo, Travis W. Hein
Summary: In diabetes, the increased activity of the enzyme arginase competes with endothelial nitric oxide synthase (eNOS) for their common substrate L-arginine, leading to compromised vasodilation mediated by nitric oxide (NO). However, eNOS uncoupling in diabetes may result in the production of superoxide and compensatory hydrogen peroxide (H2O2) formation to restore NO deficiency. This study found that in early type 1 diabetes, the vasodilation response in coronary arterioles was partially impaired due to reduced availability of L-arginine as a result of upregulated arginase activity. Nevertheless, the increased production of H2O2 during eNOS uncoupling and PI3K activation seemed to compensate for the NO deficiency and mask the disturbance caused by arginase activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Javier Saenz-Medina, Mercedes Munoz, Claudia Rodriguez, Cristina Contreras, Ana Sanchez, Maria Jose Coronado, Elvira Ramil, Martin Santos, Joaquin Carballido, Dolores Prieto
Summary: This study found that urolithiasis leads to endothelial dysfunction in preglomerular arteries, accompanied by an increase in renal cortex superoxide generation and the development of vascular inflammation. Pathways involving xanthine oxidase, Nox1, and Nox2 also play a role in this process.
Article
Andrology
Zhe Tang, Jingyu Song, Zhe Yu, Kai Cui, Yajun Ruan, Yang Liu, Tao Wang, Shaogang Wang, Jihong Liu, Jun Yang
Summary: This study demonstrates that miRNA-92a inhibitor can effectively inhibit oxidative stress and endothelial dysfunction in diabetic erectile dysfunction (ED), thus improving erectile function in diabetic rats.
WORLD JOURNAL OF MENS HEALTH
(2023)
Review
Medicine, Research & Experimental
Amarjot Kaur Grewal, Thakur Gurjeet Singh, Deepak Sharma, Veerta Sharma, Manjinder Singh, Md. Habibur Rahman, Agnieszka Najda, Magdalena Walasek-Janusz, Mohamed Kamel, Ghadeer M. Albadrani, Muhammad Furqan Akhtar, Ammara Saleem, Mohamed M. Abdel-Daim
Summary: Quercetin, a flavonoid widely distributed among plants, has significant pharmacological effects and therapeutic potential, showing neuroprotection by modulating and inhibiting a wide range of pathways. Its exact mechanisms of action remain a mystery, but studies have explored its role in enhancing neuronal longevity and neurogenesis in the context of neurodegenerative diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Andrology
Taotao Sun, Wenchao Xu, Jiaxin Wang, Tao Wang, Shaogang Wang, Kang Liu, Jihong Liu
Summary: This study investigated the effect and possible mechanisms of Saxagliptin (Sax) in the treatment of diabetes mellitus-induced erectile dysfunction (DMED). The results showed that Sax could alleviate DMED by increasing SDF-1 and activating the PI3K/AKT pathway, while also mitigating endothelial dysfunction, oxidative stress, and apoptosis. This suggests that DPP-4 may be beneficial for the management of DMED.
Article
Oncology
Wei Zhang, Jianzhou Liu, Jianxin Qiu, Xiaoliang Fu, Qisheng Tang, Fan Yang, Zhiguang Zhao, He Wang
Article
Multidisciplinary Sciences
Yong Wang, He Wang, Wei Zhang, Chen Shao, Peng Xu, Chang Hong Shi, Jian Guo Shi, Yu Mei Li, Qiang Fu, Wei Xue, Yong Hua Lei, Jing Yu Gao, Juan Ying Wang, Xiao Ping Gao, Jin Qing Li, Jian Lin Yuan, Yun Tao Zhang
Article
Oncology
Jinbo Sun, Qisheng Tang, Yongheng Gao, Wei Zhang, Zhining Zhao, Fan Yang, Xiangnan Hu, Dan Zhang, Yong Wang, Huizhong Zhang, Bin Song, Bo Zhang, He Wang
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2020)