Therapeutic potential of nuclear receptor agonists in Alzheimer’s disease

PPARγ Co-Activator-1α (PGC-1α) Reduces Amyloid-β Generation Through a PPARγ-Dependent Mechanism

(2018) Loukia Katsouri et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease

(2018) James L. Searcy et al.   JOURNAL OF ALZHEIMERS DISEASE

Omega-3 Fatty Acids Enhance Phagocytosis of Alzheimer's Disease-Related Amyloid-β42 by Human Microglia and Decrease Inflammatory Markers

(2018) Erik Hjorth et al.   JOURNAL OF ALZHEIMERS DISEASE

Cooperative Therapeutic Action of Retinoic Acid Receptor and Retinoid X Receptor Agonists in a Mouse Model of Alzheimer's Disease

(2018) Kohichi Kawahara et al.   JOURNAL OF ALZHEIMERS DISEASE

Peroxisome Proliferator-Activated Receptor Gamma Enhances the Activity of an Insulin Degrading Enzyme-Like Metalloprotease for Amyloid-β

(2017) Ira Espuny-Camacho et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease

(2017) M. M. Mariani et al.   Scientific Reports

PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice

(2016) Junya Toba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cyanidin 3- O -β-glucopyranoside activates peroxisome proliferator-activated receptor-γ and alleviates cognitive impairment in the APP swe /PS1 ΔE9 mouse model

(2016) Nan Song et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer’s Disease

(2016) Ming Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer’s Disease

(2016) Vicent Bonet-Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification and in Vivo Evaluation of Liver X Receptor β-Selective Agonists for the Potential Treatment of Alzheimer’s Disease

(2016) Shawn J. Stachel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Attenuation of  -Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity

(2016) P. Yuan et al.   JOURNAL OF NEUROSCIENCE

The nuclear cofactor receptor interacting protein-140 (RIP140) regulates the expression of genes involved in Aβ generation

(2016) Katrin Blondrath et al.   NEUROBIOLOGY OF AGING

RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers

(2016) Kyong Nyon Nam et al.   Scientific Reports

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease

(2016) Zun-Jing Liu et al.   Frontiers in Pharmacology

Role of Liver X Receptor in AD Pathophysiology

(2016) Adrián G. Sandoval-Hernández et al.   PLoS One

Localization of PPAR isotypes in the adult mouse and human brain

(2016) Anna Warden et al.   Scientific Reports

Effect of pioglitazone medication on the incidence of dementia

(2015) Michael T. Heneka et al.   ANNALS OF NEUROLOGY

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice

(2015) Avik Roy et al.   Cell Metabolism

Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice

(2015) Rebecca Skerrett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver X Receptor Agonist Modifies the DNA Methylation Profile of Synapse and Neurogenesis-Related Genes in the Triple Transgenic Mouse Model of Alzheimer’s Disease

(2015) A. G. Sandoval-Hernández et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice

(2015) Angela W. Corona et al.   Journal of Neuroimmune Pharmacology

Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation

(2015) Tarja Malm et al.   Journal of Neuroinflammation

Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism

(2015) Miroslav N. Nenov et al.   JOURNAL OF NEUROPHYSIOLOGY

Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity

(2015) A. Mounier et al.   JOURNAL OF NEUROSCIENCE

Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease

(2015) B. T. Casali et al.   JOURNAL OF NEUROSCIENCE

Nuclear Receptors License Phagocytosis by Trem2+ Myeloid Cells in Mouse Models of Alzheimer's Disease

(2015) J. C. Savage et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP

(2015) Grant T. Corbett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol metabolism and homeostasis in the brain

(2015) Juan Zhang et al.   Protein & Cell

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands

(2014) Marco Fidaleo et al.   CURRENT MEDICINAL CHEMISTRY

Amyloid-β Pathology andAPOEGenotype Modulate Retinoid X Receptor Agonist Activityin Vivo

(2014) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic and Cognitive Improvements by Inhibition of 2-AG Metabolism Are through Upregulation of MicroRNA-188-3p in a Mouse Model of Alzheimer's Disease

(2014) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene

(2014) A. Boehm-Cagan et al.   JOURNAL OF NEUROSCIENCE

PPAR  Recruitment to Active ERK during Memory Consolidation Is Required for Alzheimer's Disease-Related Cognitive Enhancement

(2014) J. B. Jahrling et al.   JOURNAL OF NEUROSCIENCE

Cognitive Enhancing Treatment with a PPARγ Agonist Normalizes Dentate Granule Cell Presynaptic Function in Tg2576 APP Mice

(2014) Miroslav N. Nenov et al.   JOURNAL OF NEUROSCIENCE

Pan-PPAR Modulation Effectively Protects APP/PS1 Mice from Amyloid Deposition and Cognitive Deficits

(2014) Markus P. Kummer et al.   MOLECULAR NEUROBIOLOGY

�-Caryophyllene Ameliorates the Alzheimer-Like Phenotype in APP/PS1 Mice through CB2 Receptor Activation and the PPARγ Pathway

(2014) Yujie Cheng et al.   PHARMACOLOGY

Role of PPARγin the Differentiation and Function of Neurons

(2014) Rodrigo A. Quintanilla et al.   PPAR Research

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist

(2013) Maria B. Goncalves et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Synthesis and Identification of New Flavonoids Targeting Liver X Receptor β Involved Pathway as Potential Facilitators of Aβ Clearance with Reduced Lipid Accumulation

(2013) Yun Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The rhythm of retinoids in the brain

(2013) Jemma Ransom et al.   JOURNAL OF NEUROCHEMISTRY

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

(2013) Jason D Ulrich et al.   Molecular Neurodegeneration

Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice

(2013) Katherine D LaClair et al.   Molecular Neurodegeneration

The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice

(2013) Kazuyoshi Kitaoka et al.   NEUROPHARMACOLOGY

Role of Nuclear Receptor on Regulation of BDNF and Neuroinflammation in Hippocampus of β-Amyloid Animal Model of Alzheimer’s Disease

(2013) Atish Prakash et al.   NEUROTOXICITY RESEARCH

Pioglitazone Improves Reversal Learning and Exerts Mixed Cerebrovascular Effects in a Mouse Model of Alzheimer’s Disease with Combined Amyloid-β and Cerebrovascular Pathology

(2013) Panayiota Papadopoulos et al.   PLoS One

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) N. F. Fitz et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) I. Tesseur et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) K. Veeraraghavalu et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) A. R. Price et al.   SCIENCE

Signaling by Nuclear Receptors

(2013) R. Sever et al.   Cold Spring Harbor Perspectives in Biology

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Expression of retinoic acid receptors and retinoid X receptors in normal and vitamin A deficient adult rat brain

(2012) Asma Arfaoui et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice

(2012) Magali Dumont et al.   HUMAN MOLECULAR GENETICS

Cognitive Enhancement with Rosiglitazone Links the Hippocampal PPAR  and ERK MAPK Signaling Pathways

(2012) L. A. Denner et al.   JOURNAL OF NEUROSCIENCE

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP/PS1 transgenic mice

(2012) W. Cui et al.   NEUROSCIENCE

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD and wild-type mice

(2012) F Masciopinto et al.   Cell Death & Disease

Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity

(2012) Federica Sarti et al.   Frontiers in Molecular Neuroscience

The retinoid X receptors and their ligands

(2011) Marcia I. Dawson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Rosiglitazone Improves Spatial Memory and Decreases Insoluble Aβ1–42 in APP/PS1 Mice

(2011) Julie-Ann O’Reilly et al.   Journal of Neuroimmune Pharmacology

Sensory Network Dysfunction, Behavioral Impairments, and Their Reversibility in an Alzheimer's  -Amyloidosis Mouse Model

(2011) D. W. Wesson et al.   JOURNAL OF NEUROSCIENCE

Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-  Expression for Microglial A  Phagocytosis

(2011) D. Terwel et al.   JOURNAL OF NEUROSCIENCE

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status

(2010) Jennifer Rodriguez-Rivera et al.   BEHAVIOURAL BRAIN RESEARCH

PPARs: diverse regulators in energy metabolism and metabolic diseases

(2010) Yong-Xu Wang   CELL RESEARCH

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

(2010) Michael Gold et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice

(2010) James J. Donkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver X Receptor Agonist Treatment Ameliorates Amyloid Pathology and Memory Deficits Caused by High-Fat Diet in APP23 Mice

(2010) N. F. Fitz et al.   JOURNAL OF NEUROSCIENCE

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

(2010) Luis Escribano et al.   NEUROPSYCHOPHARMACOLOGY

Retinoid X receptor   controls innate inflammatory responses through the up-regulation of chemokine expression

(2010) V. Nunez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

PPARγ transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons

(2009) Jing Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in Alzheimer’s Disease

(2009) Qingguang Jiang et al.   CNS DRUGS

A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease

(2009) Sergey Kalinin et al.   Current Alzheimer Research

Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin

(2009) Frank Tippmann et al.   FASEB JOURNAL

Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling

(2009) Hiroshi Katsuki et al.   JOURNAL OF NEUROCHEMISTRY

Differential SUMOylation of LXRα and LXRβ Mediates Transrepression of STAT1 Inflammatory Signaling in IFN-γ-Stimulated Brain Astrocytes

(2009) Jee Hoon Lee et al.   MOLECULAR CELL

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease

(2009) E M Toledo et al.   MOLECULAR PSYCHIATRY

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

(2009) Tim Vanmierlo et al.   NEUROBIOLOGY OF AGING

Inflammation, microglia, and alzheimer's disease

(2009) Brent Cameron et al.   NEUROBIOLOGY OF DISEASE

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer’s disease mouse model

(2008) Luis Escribano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor   Agonist

(2008) N. Nicolakakis et al.   JOURNAL OF NEUROSCIENCE

Retinoic Acid Attenuates  -Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model

(2008) Y. Ding et al.   JOURNAL OF NEUROSCIENCE

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

Peroxisome Proliferator-Activated Receptorβ/δin the Brain: Facts and Hypothesis

(2008) M. G. Hall et al.   PPAR Research

Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists

(2007) Ramya Kapadia   Frontiers in Bioscience-Landmark