Review
Oncology
Ying Jin, Soek Sin Teh, Harrison Lik Nang Lau, Jianbo Xiao, Siau Hui Mah
Summary: Retinoids, specifically synthetic retinoids, have shown potential as anti-cancer agents with high selectivity, efficacy, and enhanced effects when combined with chemotherapy drugs. However, further clinical studies need to be conducted to explore their full potential.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Immunology
Padmavathy Ramanarayanan, Guido Heine, Margitta Worm
Summary: This review discusses the roles of vitamin A and vitamin D in B cell development and function, as well as their impacts on immunoglobulin class switching, B cell migration, and homing. The combined effects of 9cRA and calcitriol on B cells are less understood and require further investigation. It is hypothesized that maintaining a balance between vitamin A and vitamin D is crucial for robust immune response and better treatment of disorders characterized by dysregulated immune responses.
IMMUNOLOGY LETTERS
(2023)
Review
Neurosciences
Anais Marie, Morgane Darricau, Katia Touyarot, Louise C. Parr-Brownlie, Clementine Bosch-Bouju
Summary: The altered retinoic acid signaling in Parkinson's disease (PD) may contribute to its pathogenesis and pathophysiology. Vitamin A and its derivatives play a crucial role in multiple biological systems and mechanisms related to PD, such as dopaminergic neuron survival, neuroinflammation, and oxidative stress. The enzyme ALDH1A1, under the control of retinoic acid, is pivotal for detoxifying neurons and may hold promise as a therapeutic target for PD management.
JOURNAL OF PARKINSONS DISEASE
(2021)
Review
Nutrition & Dietetics
Pernille Tveden-Nyborg
Summary: Severe and long-term vitamin C deficiency can lead to fatal scurvy, while a moderate deficiency may affect up to 10% of the Western population. The brain's high levels of vitamin C during deficiency suggest its importance, particularly during development, but research on non-scorbutic states of deficiency remains limited.
Article
Dentistry, Oral Surgery & Medicine
Q. Dai, S. Sun, A. Jin, X. Gong, H. Xu, Y. Yang, X. Huang, X. Wang, Y. Liu, J. Gao, X. Gao, J. Liu, Q. Bian, Y. Wu, L. Jiang
Summary: Retinoid signaling disorders cause craniofacial deformity. Conditional expression of dominant-negative RAR alpha mutation in mice mimicked VAD craniofacial defects and confirmed abnormalities in craniofacial bones. Inhibition of RAR in osteoblasts impaired bone formation and bone resorption.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Fisheries
Karsoon Tan, Longhui Deng, Hongkuan Zhang, Hongyu Ma, Shengkang Li, Huaiping Zheng
Summary: The study identified the RAR and RXR genes in the noble scallop C. nobilis and their potential roles in carotenoid accumulation, suggesting important regulatory mechanisms for further investigation.
AQUACULTURE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Nicola Alessio, Carmela Belardo, Maria Consiglia Trotta, Salvatore Paino, Serena Boccella, Francesca Gargano, Gorizio Pieretti, Flavia Ricciardi, Ida Marabese, Livio Luongo, Umberto Galderisi, Michele D'Amico, Sabatino Maione, Francesca Guida
Summary: Vitamin D deficiency leads to significant changes in microglia cells, suggesting a potential role of these cells in sensory dysfunctions associated with hypovitaminosis D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Genetics & Heredity
Giacomo Voltan, Michele Cannito, Michela Ferrarese, Filippo Ceccato, Valentina Camozzi
Summary: Vitamin D plays a crucial role in calcium and phosphate metabolism, bone health, and various extra-skeletal functions. It binds to vitamin D receptors (VDRs) in different tissues, modulating the expression of numerous target genes. Gene polymorphisms in VDRs may influence gene expression, leading to the development of chronic diseases and metabolic complications.
Review
Nutrition & Dietetics
Xiaoying Cui, Darryl W. Eyles
Summary: This article provides an update on the actions of vitamin D in the brain and the cellular processes it may target in psychiatry and neurology.
Article
Biochemistry & Molecular Biology
Pulak R. Manna, Arubala P. Reddy, Jangampalli Adi Pradeepkiran, Sudhir Kshirsagar, P. Hemachandra Reddy
Summary: Retinoids enhance the expression and biosynthesis of StAR and pregnenolone in hippocampal neuronal cells. The retinoic acid receptor (RAR)/retinoid X receptor (RXR)-liver X receptor (LXR) sequence motif plays an important role in retinoid responsiveness. StAR protects against toxicities induced by mutant APP or mutant Tau and modulates neurosteroidogenesis and hormonal balance, suggesting its potential role in protecting against Alzheimer's disease and age-related complications and diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Chemistry, Organic
Takashi Okitsu, Kinya Iwatsuka, Kimie Nakagawa, Toshio Okano, Akimori Wada
Summary: A series of 9-cis-retinoic acid analogues with aromatic rings were synthesized in two steps and evaluated for their transcriptional activities. Compound 6c, with a 2-naphthyl substituent, displayed the highest transcriptional activity and showed selectivity for RXR.
Review
Nutrition & Dietetics
Zsolt Gall, Orsolya Szekely
Summary: The review highlights the importance of the neuronal effects of 1,25(OH)2D in cognitive development and maintenance, as well as the association between vitamin D deficiency and neurological disorders. It also discusses the expression of vitamin D receptors in the central nervous system and the potential implications for therapeutic applications.
Article
Pediatrics
Birger Trollfors
Summary: This study aimed to explore the adherence to vitamin D supplementation recommendations among children aged 0-4 years and compare the serum levels of vitamin D in children and adolescents from different parts of the world. It was found that immigrant children in Sweden commonly had vitamin D deficiency.
Article
Public, Environmental & Occupational Health
Huan Liu, Qixiong Chen, Linchao Yu, Ting Yang, Jie Chen, Jingkun Miao, Tingyu Li
Summary: The study found that vitamin A levels in healthy infants increased significantly with age, even without additional supplementation. The percentage of infants with low vitamin A levels decreased from birth to 6 months. No infants showed clinical signs of vitamin A deficiency during the follow-up period.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Andreas Kislat, Peter Olah, Marcus Kuchner, Peter Arne Gerber, Juergen Schrader, Stephan Meller, Bernhard Homey
Summary: Alitretinoin, a dual RAR and RXR agonist, targets skin dysregulation and exerts strong immunomodulatory effects on antigen presenting cells, leading to the treatment of chronic hand eczema with remarkable efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mouloud Lamtai, Sofia Azirar, Oussama Zghari, Sihame Ouakki, Aboubaker El Hessni, Abdelhalem Mesfioui, Ali Ouichou
Summary: The present study revealed the potential of melatonin in combating neurobehavioral changes induced by chronic exposure to cadmium. Melatonin can alleviate cadmium-induced anxiety, depression, and memory impairments, with antioxidant effects, focusing on neuroprotection in the hippocampal region. Additionally, the protective effects of melatonin are sex-dependent, being more pronounced in females.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Mouloud Lamtai, Oussama Zghari, Sofia Azirar, Sihame Ouakki, Abdelhalem Mesfioui, Aboubaker EL Hessni, Inssaf Berkiks, Ilias Marmouzi, Ali Ouichou
Summary: Melatonin treatment exerts neuroprotective effects against copper-induced neurobehavioral changes, including alleviating anxiety-like and depression-like behaviors, improving memory deficits, reducing oxidative stress levels, and enhancing antioxidant enzyme activities; these effects are more pronounced in female rats.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rafael Moreno-Gomez-Toledano, Maria Arenas, Carmen Munoz-Moreno, Nuria Olea-Herrero, Paula Reventun, Adriana Izquierdo-Lahuerta, Alba Anton-Cornejo, Marta Gonzalez-Santander, Carlos Zaragoza, Marta Saura, Ricardo J. Bosch
Summary: Research has shown that BPA exposure can lead to kidney alterations that resemble early diabetic nephropathy, such as increased kidney damage biomarkers, urinary albumin excretion, and hypertension. Additionally, male mice exposed to BPA exhibited more severe adverse effects, displaying a pattern of sexual dimorphism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Entomology
Chaimae Ramdani, Karim El Fakhouri, Mohamed Sbaghi, Rachid Bouharroud, Rachid Boulamtat, Abderrahim Aasfar, Abdelhalim Mesfioui, Mustapha El Bouhssini
Summary: The study showed that the essential oils of Mentha pulegium and Origanum vulgare can be effective natural insecticides for controlling the wild cochineal Dactylopius opuntiae in Morocco, especially when used in combination with black soap.
Article
Public, Environmental & Occupational Health
Majdouline El Fouhi, Bouchra Haddou Rahou, Abdelhalim Mesfioui, Abdellatif Benider
Summary: Cancer, especially breast cancer, poses a significant public health challenge. This study is the first in our country to examine the quality of life in male breast cancer patients, and it reveals that their quality of life is generally better than expected. The results show positive scores in physical function, emotional functioning, and social functioning in male patients with breast cancer.
PAN AFRICAN MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Ayoub Rezqaoui, Laila Ibouzine-dine, Abdelghafour Elhamzaoui, Mohamed Yassine El Brouzi, Amal Dimaoui, Aboubaker El Hessni, Abdelhalem Mesfioui
Summary: In this study, we examined the effects of chronic iron exposure on cognitive and affective disorders and oxidative stress in male Wistar rats. The rats were treated with different doses of iron sulfate for 8 weeks. Affective and cognitive disorders were assessed through various tests, and biochemical examination was conducted on the hippocampus and prefrontal cortex of each animal. The results showed that iron exposure induced anxiogenic and depressogenic effects, as well as cognitive disorders and oxidative stress. Chronic iron exposure was found to be associated with the development of cognitive and affective disorders and oxidative stress.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Neurosciences
Abderrahim Laaziz, Hicham El Mostafi, Aboubaker Elhessni, Tarik Touil, Hanane Doumar, Abdelhalem Mesfioui
Summary: The study showed that chronic administration of DEX can lead to a range of depression-related behavioral traits, including anhedonia, despair, weight loss, anxiety-like behavior, and cognitive impairments, which fulfill the face validity criterion. The behavioral changes induced by DEX may result from the massive production of oxidative stress agents.
IBRO NEUROSCIENCE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Rabab Ez-Zriouli, Houda ElYacoubi, Hamada Imtara, Abdelhalim Mesfioui, Aboubaker ElHessni, Omkulthom Al Kamaly, Samar Zuhair Alshawwa, Fahd A. A. Nasr, Zineb Benziane Ouaritini, Atmane Rochdi
Summary: The yield of essential oils from Cedrus atlantica, Chenopodium ambrosioides and Eucalyptus camaldulensis varied, with Chenopodium ambrosioides having the highest yield and Eucalyptus camaldulensis having the lowest. The chemical compositions and biological effects of the essential oils were also different, with significant antioxidant and antimicrobial activities observed.
Review
Nutrition & Dietetics
Fatima Ezzahra Kacimi, Soumia Ed-day, Latifa Didou, Fatima Zahra Azzaoui, Mhamed Ramchoun, Asma Arfaoui, Samira Boulbaroud
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by a lack of social behaviors, repetitive behaviors and nonverbal interactions. Studies have shown that the gut microbiota may play a role in the pathophysiology of ASD. However, the relationship between the gut microbiota and ASD is still not fully understood.
JOURNAL OF DIETARY SUPPLEMENTS
(2023)
Article
Sport Sciences
El Mokhtar El Ouali, Hassane Zouhal, Loubna Bahije, Azeddine Ibrahimi, Bahae Benamar, Jihan Kartibou, Ayoub Saeidi, Ismail Laher, Sanae El Harane, Urs Granacher, Abdelhalem Mesfioui
Summary: The aim of this study was to determine the effect of malocclusion on maximal aerobic capacity in young athletes, and the study found that malocclusion does not affect the maximal aerobic capacity and athletic performance of track and field athletes.
Article
Urology & Nephrology
Miloud Chakit, Aziz Aqira, Aboubaker El Hessni, Abdelhalim Mesfioui
Summary: This study evaluated the effectiveness of extracorporeal shockwave lithotripsy (ESWL) in the treatment of nephrolithiasis in the North of Morocco. The results showed that ESWL is highly successful in treating human kidney stones and is considered the first choice treatment modality for this pathology in the population of this area.
Article
Food Science & Technology
Chaimae Ramdani, Karim El Fakhouri, Rachid Boulamtat, Rachid Bouharroud, Abdelhalim Mesfioui, Muamar Al-Jaboobi, Mustapha El Bouhssini
Summary: The cactus Opuntia ficus-indica L. plays a vital economic role in Morocco, but its cultivation is threatened by the Dactylopius opuntiae insect pest. This study explored the use of entomopathogenic fungi as a biopesticide alternative to chemical pesticides for controlling D. opuntiae. The results showed that certain fungal isolates, such as B. bassiana and A. lecanii, demonstrated high insecticidal activity against both nymphs and adult females of D. opuntiae.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2022)
Article
Public, Environmental & Occupational Health
Ibrahim Hinad, Youssef S'hih, Aboubaker Elhessni, Abdelhalim Mesfioui, Moulay Laarbi Ouahidi
Summary: Diabetic patients in the Ksar Elkebir region of Morocco use a variety of herbal remedies to treat diabetes, with commonly used plant species including Olea europaea, Trigonella foenum graecum, Origanum compactum, and Salvia officinalis. They typically utilize plant leaves and decoctions as the preferred mode of preparation.
PAN AFRICAN MEDICAL JOURNAL
(2022)
Article
Psychiatry
El Hassan Ouanouche, Hicham Elmostafi, Naoufal Amarat, Ouahid Wafaa, Tamouza Ryad, Aboubaker El Hessni, Abdelhalem Mesfioui
Summary: The study found a clear association between cannabis use and the onset and severity of schizophrenia. Cannabis users tended to be younger, predominantly male, and have lower educational and economic levels compared to non-users. The results also suggest a dose effect of cannabis use on schizophrenia symptoms, with the age of onset of cannabis use being a significant predictive factor.
MIDDLE EAST CURRENT PSYCHIATRY-MECPSYCH
(2022)
Article
Chemistry, Multidisciplinary
Rabab Ez-Zriouli, Houda El Yacoubi, Hamada Imtara, Aboubaker El-Hessni, Abdelhalim Mesfioui, Mahmoud Tarayrah, Ramzi A. Mothana, Omar Mohammed Noman, Fatine Mouhsine, Atmane Rochdi
Summary: This article aimed to study the antimicrobial activity, chemical composition, and acute oral toxicity of essential oils from Mentha pulegium and Rosmarinus officinalis. The results showed that the oils had significant antimicrobial effects against resistant strains and contained compounds that are potentially effective against these microorganisms. Based on the toxicity tests, the oils were found to be marginally safe and could be further explored as bio-products with low risk potential.
Article
Anatomy & Morphology
Rongyan Sun, Yubo Zhou, Jiao Liang, Lihong Yang, Zhengjun Fan, Huali Wang
Summary: This study found that knockdown of MDM2 can attenuate vascular endothelial dysfunction in hypertension, which may be achieved through inhibiting the activation of Notch1 and NLRP3 inflammasome.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
E. M. Fernandez-Rubio, R. J. Radlanski
Summary: This study investigates the development of the primary and secondary temporomandibular joints in humans, focusing on their coexistence and subsequent separation. The findings reveal that both joints develop simultaneously and remain connected for over 6 weeks before separating at around the 18th to 24th week. Understanding the precise timing and functional movements involved in the development of these joints is crucial for comprehending the overall development of the temporomandibular joint.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
Nawwaf Sebastian Damen, Sorin Hostiuc, Adelina Maria Jianu, Bogdan Adrian Manta, Mugurel Constantin Rusu, Mihai Adrian Dobra
Summary: This study documented the anatomical variations of the left renal vein (LRV) through a retrospective analysis of 375 computed tomography angiograms. Five different anatomical types of LRV were identified, and a new anatomical classification system for the retroaortic LRV (RLRV) was proposed.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
Harald Knof, Markus Berndt, Thomas Shiozawa
Summary: This study investigated the impact of online learning conditions on the oral exam performance of medical students. The results showed that students who used collaborative learning strategies were able to assess their abilities more realistically. However, the learning strategies did not have an impact on exam results.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Review
Anatomy & Morphology
Felix Margenfeld, Adib Zendehdel, Giorgio Tamborrini, Magdalena Mueller-Gerbl
Summary: This study is the first scoping review to screen ultrasound studies on human cadaver joints and revealed a heterogeneous field. It is recommended to use a uniform method for conducting and presenting ultrasound examinations in future studies.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
Rafael Heiss, Svenja A. Hoeger, Michael Uder, Thilo Hotfiel, Jannis Hanspach, Frederik B. Laun, Armin M. Nagel, Frank W. Roemer
Summary: This study utilized 7 Tesla magnetic resonance imaging (MRI) to assess morphological and functional changes in skeletal muscle during exercise-induced delayed onset muscle soreness (DOMS). The results showed significant alterations in T2 signal intensity and T2 values immediately after exercise and 60 hours later. These findings suggest the potential use of ultra-high field MRI in sports medicine to monitor microstructural muscle damage and guide appropriate therapeutic strategies.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
Lukasz Olewnik, Nicol Zielinska, Kacper Ruzik, Michal Podgorski, Przemyslaw Kicinski, Rui Diogo, Friedrich Paulsen
Summary: This study provides the first comprehensive classification of the fibularis brevis tendon based on its insertion in human fetuses and evaluates the prevalence of fibularis digiti quinti.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
Denise Bonente, Virginia Barone, Vitaliano Francesco Muzii, Sara Ottolenghi, Miriam Durante, Sandra Bracco, Claudio Nicoletti, Eugenio Bertelli
Summary: This study characterizes the morphology and topography of the spina musculi recti lateralis (SMRL) and compares it to known bony landmarks. The results show that the SMRL is a process of the sphenoidal orbital plate and serves as a reliable landmark for the insertion of the tendinous ring and lateral rectus. This is an important variation for orbital surgeons to be aware of.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
Article
Anatomy & Morphology
Fatih Cicek, Selim Cinaroglu, Faruk Gazi Ceranoglu, Erkut Kucuk, Kursad Ramazan Zor
Summary: This study revealed the nerve innervation of the orbicularis oculi muscle for BoNT treatment of blepharospasm using Sihler's staining technique. It identified precise crossing points of these nerves, which can be targeted for BoNT administration, leading to more efficient outcomes and reduced expenses.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
