Role of Liver X Receptor in AD Pathophysiology

Pyroglutamylated amyloid-β is associated with hyperphosphorylated tau and severity of Alzheimer’s disease

(2014) Markus Mandler et al.   ACTA NEUROPATHOLOGICA

Interactions between Amyloid-β and Tau Fragments Promote Aberrant Aggregates: Implications for Amyloid Toxicity

(2014) Thanh D. Do et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells

(2014) Miguel Moutinho et al.   MOLECULAR NEUROBIOLOGY

Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

(2014) Meredith A. Chabrier et al.   NEUROBIOLOGY OF DISEASE

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ϵ4, and the Risk of Late-Onset Alzheimer Disease in African Americans

(2013) Christiane Reitz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity

(2013) Tomonori Ishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) N. F. Fitz et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) A. R. Price et al.   SCIENCE

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Lipid Metabolism and Neuroinflammation in Alzheimer's Disease: A Role for Liver X Receptors

(2012) Jihong Kang et al.   ENDOCRINE REVIEWS

R6/2 Huntington's Disease Mice Develop Early and Progressive Abnormal Brain Metabolism and Seizures

(2012) E. Cepeda-Prado et al.   JOURNAL OF NEUROSCIENCE

Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis

(2012) Spyridon Theofilopoulos et al.   Nature Chemical Biology

Age-related changes in neuroactive steroid levels in 3xTg-AD mice

(2012) Donatella Caruso et al.   NEUROBIOLOGY OF AGING

Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits

(2012) Julie A. Harris et al.   PLoS One

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Synapses and Alzheimer's Disease

(2012) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

ApoE is required for maintenance of the dentate gyrus neural progenitor pool

(2011) C.-P. Yang et al.   DEVELOPMENT

Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-  Expression for Microglial A  Phagocytosis

(2011) D. Terwel et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices

(2011) Gerhard Rammes et al.   NEUROPHARMACOLOGY

Oxysterols: A world to explore

(2010) A. Otaegui-Arrazola et al.   FOOD AND CHEMICAL TOXICOLOGY

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice

(2010) James J. Donkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PLASMA LIPID DISTURBANCES AND COGNITIVE DECLINE

(2010) Vincenza Frisardi et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease

(2010) Lesley Jones et al.   PLoS One

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

(2009) Gang Li et al.   Cell Stem Cell

Oxysterols Drive Dopaminergic Neurogenesis from Stem Cells

(2009) Dengke K. Ma et al.   Cell Stem Cell

Liver X Receptors and Oxysterols Promote Ventral Midbrain Neurogenesis In Vivo and in Human Embryonic Stem Cells

(2009) Paola Sacchetti et al.   Cell Stem Cell

Amyloid-β interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons

(2009) Tsan-Ju Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Molecular regulation of neuronal migration during neocortical development

(2009) Zhen Huang   MOLECULAR AND CELLULAR NEUROSCIENCE

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

(2009) Tim Vanmierlo et al.   NEUROBIOLOGY OF AGING

Synaptic Depression and Aberrant Excitatory Network Activity in Alzheimer’s Disease: Two Faces of the Same Coin?

(2009) Jorge J. Palop et al.   NEUROMOLECULAR MEDICINE

Synaptic transmission block by presynaptic injection of oligomeric amyloid beta

(2009) H. Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Higher total cholesterol, cognitive decline, and dementia

(2008) Francesco Panza et al.   NEUROBIOLOGY OF AGING

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease

(2008) José J. Rodríguez et al.   PLoS One

LTP maintenance and its protein synthesis-dependence

(2007) Wickliffe C. Abraham et al.   NEUROBIOLOGY OF LEARNING AND MEMORY