Interferons and beyond: Induction of antiretroviral restriction factors

Interferon epsilon promotes HIV restriction at multiple steps of viral replication

(2017) Albert Garcia-Minambres et al.   IMMUNOLOGY AND CELL BIOLOGY

Cytokines Elevated in HIV Elite Controllers Reduce HIV Replication In Vitro and Modulate HIV Restriction Factor Expression

(2017) Evan S. Jacobs et al.   JOURNAL OF VIROLOGY

The Envelope Gene of Transmitted HIV-1 Resists a Late Interferon Gamma-Induced Block

(2017) Suzannah J. Rihn et al.   JOURNAL OF VIROLOGY

Refining strategies to translate genome editing to the clinic

(2017) Tatjana I Cornu et al.   NATURE MEDICINE

Antiviral Goes Viral: Harnessing CRISPR/Cas9 to Combat Viruses in Humans

(2017) Jasper Adriaan Soppe et al.   TRENDS IN MICROBIOLOGY

Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells

(2017) Marielle Cavrois et al.   Cell Reports

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

The therapeutic landscape of HIV-1 via genome editing

(2017) Alexander Kwarteng et al.   AIDS Research and Therapy

Emerging and Neglected Infectious Diseases: Insights, Advances, and Challenges

(2017) Nicholas Israel Nii-Trebi   Biomed Research International

Ethical and regulatory aspects of genome editing

(2016) Donald B. Kohn et al.   BLOOD

The clinical applications of genome editing in HIV

(2016) Cathy X. Wang et al.   BLOOD

Origins and Evolution of tetherin , an Orphan Antiviral Gene

(2016) Daniel Blanco-Melo et al.   Cell Host & Microbe

The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild

(2016) Anke Heigele et al.   Cell Host & Microbe

Identification of Interferon-Stimulated Genes with Antiretroviral Activity

(2016) Melissa Kane et al.   Cell Host & Microbe

Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction

(2016) Toshana L. Foster et al.   Cell Host & Microbe

Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity

(2016) Christian Krapp et al.   Cell Host & Microbe

Engineering hematopoietic stem cells toward a functional cure of human immunodeficiency virus infection

(2016) Jianbin Wang et al.   CYTOTHERAPY

TALEN gene editing takes aim on HIV

(2016) Ronald Benjamin et al.   HUMAN GENETICS

Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a

(2016) Maximilian Riess et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interferon Alpha Subtype-Specific Suppression of HIV-1 InfectionIn Vivo

(2016) Kerry J. Lavender et al.   JOURNAL OF VIROLOGY

Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution

(2016) Richard N. McLaughlin et al.   MOLECULAR BIOLOGY AND EVOLUTION

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

(2016) Ryan J Park et al.   NATURE GENETICS

Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance

(2016) Dorota Kmiec et al.   mBio

HIV replication

(2016) Daniel Sauter et al.   Current Opinion in HIV and AIDS

IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle

(2016) Mayte Coiras et al.   Cell Reports

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

(2016) George Savidis et al.   Cell Reports

SnapShot: Antiviral Restriction Factors

(2015) Silvia F. Kluge et al.   CELL

Perspectives of Genome-Editing Technologies for HIV Therapy

(2015) Hirotaka Ebina et al.   CURRENT HIV RESEARCH

Comparison of Antiviral Activity of Lambda-Interferons Against HIV Replication in Macrophages

(2015) Yizhong Wang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Early Vertebrate Evolution of the Host Restriction Factor Tetherin

(2015) Elena Heusinger et al.   JOURNAL OF VIROLOGY

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

(2015) Yoshiko Usami et al.   NATURE

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

(2015) Annachiara Rosa et al.   NATURE

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

Therapeutic genome editing: prospects and challenges

(2015) David Benjamin Turitz Cox et al.   NATURE MEDICINE

MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins

(2015) Takuya Tada et al.   NATURE MEDICINE

HIV-1 and interferons: who's interfering with whom?

(2015) Tomas Doyle et al.   NATURE REVIEWS MICROBIOLOGY

Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators

(2015) Hal P. Bogerd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter

(2015) Filippo Turrini et al.   Retrovirology

IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein

(2015) Jingyou Yu et al.   Cell Reports

The Challenge of a “Functional Cure” for AIDS by Gene Modified HSCT Therapy

(2015) Lei Xu et al.   Current Stem Cell Research & Therapy

Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms

(2015) Michael S. Harper et al.   PLoS Pathogens

Type I Interferon: Understanding Its Role in HIV Pathogenesis and Therapy

(2015) Steven E. Bosinger et al.   Current HIV/AIDS Reports

Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing

(2014) Nadine Laguette et al.   CELL

IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread

(2014) Alex A. Compton et al.   Cell Host & Microbe

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-27 Is Differentially Associated with HIV Viral Load and CD4+ T Cell Counts in Therapy-Naïve HIV-Mono-Infected and HIV/HCV-Co-Infected Chinese

(2014) Lai He et al.   PLoS One

Plasma Interleukin-27 (IL-27) Levels Are Not Modulated in Patients with Chronic HIV-1 Infection

(2014) Sanjay Swaminathan et al.   PLoS One

IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity

(2014) Kevin Tartour et al.   Retrovirology

Toll-Like Receptor Agonists Are Potent Inhibitors of Human Immunodeficiency Virus-Type 1 Replication in Peripheral Blood Mononuclear Cells

(2013) Maarten Buitendijk et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Interleukin-27 treated human macrophages induce the expression of novel microRNAs which may mediate anti-viral properties

(2013) Sanjay Swaminathan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection

(2013) Zhenlong Liu et al.   Cell Host & Microbe

Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection

(2013) Sanjay Swaminathan et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Interleukin-2 Inhibits HIV-1 Replication in Some Human T Cell Lymphotrophic Virus-1-infected Cell Lines via the Induction and Incorporation of APOBEC3G into the Virion

(2013) Raphael M. Oguariri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation

(2013) Lue Dai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Restriction of HIV-1 Replication in Primary Macrophages by IL-12 and IL-18 through the Upregulation of SAMHD1

(2013) E. Pauls et al.   JOURNAL OF IMMUNOLOGY

Effects of Cellular Activation on Anti-HIV-1 Restriction Factor Expression Profile in Primary Cells

(2013) R. A. S. Raposo et al.   JOURNAL OF VIROLOGY

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

MX2 is an interferon-induced inhibitor of HIV-1 infection

(2013) Melissa Kane et al.   NATURE

Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells

(2013) Xiying Qu et al.   NUCLEIC ACIDS RESEARCH

Interferon-α Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers

(2013) Gareth A. D. Hardy et al.   PLoS One

Interleukin-27 Is a Potent Inhibitor of cis HIV-1 Replication in Monocyte-Derived Dendritic Cells via a Type I Interferon-Independent Pathway

(2013) Qian Chen et al.   PLoS One

90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1

(2013) Veronika Lodermeyer et al.   Retrovirology

Expression profile of host restriction factors in HIV-1 elite controllers

(2013) Mohamed Abdel-Mohsen et al.   Retrovirology

Relative resistance of HIV-1 founder viruses to control by interferon-alpha

(2013) Angharad E Fenton-May et al.   Retrovirology

Interferon-  Protects the Female Reproductive Tract from Viral and Bacterial Infection

(2013) K. Y. Fung et al.   SCIENCE

Phosphorylation of SAMHD1 by Cyclin A2/CDK1 Regulates Its Restriction Activity toward HIV-1

(2013) Alexandra Cribier et al.   Cell Reports

IFITM Proteins Restrict Viral Membrane Hemifusion

(2013) Kun Li et al.   PLoS Pathogens

IFN-λ inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production

(2012) Ren-Rong Tian et al.   ANTIVIRAL RESEARCH

Inhibition of HIV-1 Particle Assembly by 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase

(2012) Sam J. Wilson et al.   Cell Host & Microbe

Innate Sensing of HIV-1 Assembly by Tetherin Induces NFκB-Dependent Proinflammatory Responses

(2012) Rui Pedro Galão et al.   Cell Host & Microbe

The Ability of Primate Lentiviruses to Degrade the Monocyte Restriction Factor SAMHD1 Preceded the Birth of the Viral Accessory Protein Vpx

(2012) Efrem S. Lim et al.   Cell Host & Microbe

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

The Restriction Factors of Human Immunodeficiency Virus

(2012) Reuben S. Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFN-  and Lipopolysaccharide Upregulate APOBEC3 mRNA through Different Signaling Pathways

(2012) H. V. Mehta et al.   JOURNAL OF IMMUNOLOGY

Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11

(2012) Manqing Li et al.   NATURE

IL-27-Induced Gene Expression Is Downregulated in HIV-Infected Subjects

(2012) Christina Guzzo et al.   PLoS One

Role of retroviral restriction factors in the interferon- -mediated suppression of HIV-1 in vivo

(2012) S. K. Pillai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

(2012) Corine St Gelais et al.   Retrovirology

Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons

(2012) Viviana Cobos Jiménez et al.   Scientific Reports

IL-27 increases BST-2 expression in human monocytes and T cells independently of type I IFN

(2012) Christina Guzzo et al.   Scientific Reports

The TRIM Family Protein KAP1 Inhibits HIV-1 Integration

(2011) Awatef Allouch et al.   Cell Host & Microbe

Binding and activity of all human alpha interferon subtypes

(2011) Thomas B. Lavoie et al.   CYTOKINE

High Susceptibility to Repeated, Low-Dose, Vaginal SHIV Exposure Late in the Luteal Phase of the Menstrual Cycle of Pigtail Macaques

(2011) Sundaram A Vishwanathan et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Evolutionary genetic dissection of human interferons

(2011) Jérémy Manry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Upregulation of BST-2/Tetherin by HIV Infection In Vivo

(2011) S. Homann et al.   JOURNAL OF VIROLOGY

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Antiviral restriction factor transgenesis in the domestic cat

(2011) Pimprapar Wongsrikeao et al.   NATURE METHODS

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation

(2011) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag

(2011) Matthew W Woods et al.   Retrovirology

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation

(2010) K. Allers et al.   BLOOD

Immune Evasion and Counteraction of Restriction Factors by HIV-1 and Other Primate Lentiviruses

(2010) Frank Kirchhoff   Cell Host & Microbe

Role of Interferon α (IFNα)-inducible Schlafen-5 in Regulation of Anchorage-independent Growth and Invasion of Malignant Melanoma Cells

(2010) Efstratios Katsoulidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-27, an Anti-HIV-1 Cytokine, Inhibits Replication of Hepatitis C Virus

(2010) Astrid C. Frank et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Guanylate-Binding Proteins: Emerging Insights into the Biochemical Properties and Functions of This Family of Large Interferon-Induced Guanosine Triphosphatase

(2010) Deborah J. Vestal et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The IFITM Proteins Inhibit HIV-1 Infection

(2010) J. Lu et al.   JOURNAL OF VIROLOGY

ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses

(2010) Sumio Hayakawa et al.   NATURE IMMUNOLOGY

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

(2010) Eric W. Refsland et al.   NUCLEIC ACIDS RESEARCH

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease

(2010) D. Favre et al.   Science Translational Medicine

Genome-Wide mRNA Expression Correlates of Viral Control in CD4+ T-Cells from HIV-1-Infected Individuals

(2010) Margalida Rotger et al.   PLoS Pathogens

IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages

(2009) Tomozumi Imamichi et al.   AIDS

Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells

(2009) M. R. Khaitov et al.   ALLERGY

Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon

(2009) T. Greenwell-Wild et al.   BLOOD

A Tail of Tetherin: How Pandemic HIV-1 Conquered the World

(2009) Ravindra K. Gupta et al.   Cell Host & Microbe

Tetherin-Driven Adaptation of Vpu and Nef Function and the Evolution of Pandemic and Nonpandemic HIV-1 Strains

(2009) Daniel Sauter et al.   Cell Host & Microbe

Interferon-γ: A historical perspective

(2009) Alfons Billiau et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Human Immunodeficiency Virus, Restriction Factors, and Interferon

(2009) Stuart Neil et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections

(2009) A. R. Stacey et al.   JOURNAL OF VIROLOGY

Defining APOBEC3 Expression Patterns in Human Tissues and Hematopoietic Cell Subsets

(2009) F. A. Koning et al.   JOURNAL OF VIROLOGY

Lambda Interferon Inhibits Human Immunodeficiency Virus Type 1 Infection of Macrophages

(2009) W. Hou et al.   JOURNAL OF VIROLOGY

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

A new strategy to understand how HIV infects women: identification of a window of vulnerability during the menstrual cycle

(2008) Charles R Wira et al.   AIDS

HIV-1 Accessory Proteins—Ensuring Viral Survival in a Hostile Environment

(2008) Michael H. Malim et al.   Cell Host & Microbe

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Implication of TRIMalpha and TRIMCyp in interferon-induced anti-retroviral restriction activities

(2008) Laetitia Carthagena et al.   Retrovirology

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE