HIV-1 and interferons: who's interfering with whom?

Origin of the HIV-1 group O epidemic in western lowland gorillas

(2015) Mirela D’arc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retroviral Retention Activates a Syk-Dependent HemITAM in Human Tetherin

(2014) Rui Pedro Galão et al.   Cell Host & Microbe

IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread

(2014) Alex A. Compton et al.   Cell Host & Microbe

Structural Insight into HIV-1 Restriction by MxB

(2014) Jennifer L. Fribourgh et al.   Cell Host & Microbe

Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection

(2014) Shivani Srivastava et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transfer of the Amino-Terminal Nuclear Envelope Targeting Domain of Human MX2 Converts MX1 into an HIV-1 Resistance Factor

(2014) C. Goujon et al.   JOURNAL OF VIROLOGY

Reprogramming human endothelial cells to haematopoietic cells requires vascular induction

(2014) Vladislav M. Sandler et al.   NATURE

Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif

(2014) Yingying Guo et al.   NATURE

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

(2014) Jeongmin Ryoo et al.   NATURE MEDICINE

IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity

(2014) Kevin Tartour et al.   Retrovirology

MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1

(2014) Thomas Fricke et al.   Retrovirology

The early spread and epidemic ignition of HIV-1 in human populations

(2014) N. R. Faria et al.   SCIENCE

Immunologic strategies for HIV-1 remission and eradication

(2014) D. H. Barouch et al.   SCIENCE

Regulating the diverse outcomes of interferon's interference

(2014) Heather D. Marshall et al.   TRENDS IN IMMUNOLOGY

Interferon-stimulated genes: roles in viral pathogenesis

(2014) John W Schoggins   Current Opinion in Virology

Innate Immune Responses and Rapid Control of Inflammation in African Green Monkeys Treated or Not with Interferon-Alpha during Primary SIVagm Infection

(2014) Béatrice Jacquelin et al.   PLoS Pathogens

Plasmacytoid Dendritic Cells Suppress HIV-1 Replication but Contribute to HIV-1 Induced Immunopathogenesis in Humanized Mice

(2014) Guangming Li et al.   PLoS Pathogens

Plasmacytoid Dendritic Cell Dynamics Tune Interferon-Alfa Production in SIV-Infected Cynomolgus Macaques

(2014) Timothée Bruel et al.   PLoS Pathogens

Human APOBEC3 Induced Mutation of Human Immunodeficiency Virus Type-1 Contributes to Adaptation and Evolution in Natural Infection

(2014) Eun-Young Kim et al.   PLoS Pathogens

The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection

(2013) Zhenlong Liu et al.   Cell Host & Microbe

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

(2013) Xavier Lahaye et al.   IMMUNITY

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

Hepatitis C Therapy With Interferon-α and Ribavirin Reduces CD4 T-Cell–Associated HIV-1 DNA in HIV-1/Hepatitis C Virus–Coinfected Patients

(2013) Hong Sun et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

MX2 is an interferon-induced inhibitor of HIV-1 infection

(2013) Melissa Kane et al.   NATURE

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

Interferon-α Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers

(2013) Gareth A. D. Hardy et al.   PLoS One

Phenotypic properties of transmitted founder HIV-1

(2013) N. F. Parrish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PNAS Plus: From the Cover: IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

(2013) M. R. Jakobsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relative resistance of HIV-1 founder viruses to control by interferon-alpha

(2013) Angharad E Fenton-May et al.   Retrovirology

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Viral and Cellular Requirements for the Nuclear Entry of Retroviral Preintegration Nucleoprotein Complexes

(2013) Kenneth Matreyek et al.   Viruses-Basel

IL-15 cis Presentation Is Required for Optimal NK Cell Activation in Lipopolysaccharide-Mediated Inflammatory Conditions

(2013) Ivan Zanoni et al.   Cell Reports

Origins of HIV and the AIDS Pandemic

(2013) P. M. Sharp et al.   Cold Spring Harbor Perspectives in Medicine

HIV Restriction Factors and Mechanisms of Evasion

(2013) M. H. Malim et al.   Cold Spring Harbor Perspectives in Medicine

Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection

(2013) Muhamuda Kader et al.   PLoS Pathogens

Type I Interferon Upregulates Bak and Contributes to T Cell Loss during Human Immunodeficiency Virus (HIV) Infection

(2013) Joseph A. Fraietta et al.   PLoS Pathogens

Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation

(2012) T. H. Vanderford et al.   BLOOD

Innate Sensing of HIV-1 Assembly by Tetherin Induces NFκB-Dependent Proinflammatory Responses

(2012) Rui Pedro Galão et al.   Cell Host & Microbe

Host Gene Expression Changes Correlating With Anti–HIV-1 Effects in Human Subjects After Treatment With Peginterferon Alfa-2a

(2012) Jonathan J. Hubbard et al.   JOURNAL OF INFECTIOUS DISEASES

Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration

(2012) Livio Azzoni et al.   JOURNAL OF INFECTIOUS DISEASES

Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11

(2012) Manqing Li et al.   NATURE

Intrinsic antiviral immunity

(2012) Nan Yan et al.   NATURE IMMUNOLOGY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

Role of retroviral restriction factors in the interferon- -mediated suppression of HIV-1 in vivo

(2012) S. K. Pillai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic identification of type I and type II interferon-induced antiviral factors

(2012) S.-Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV Interplay with SAMHD1

(2012) T. Schaller et al.   SCIENCE

Hiding in Plain Sight: How HIV Evades Innate Immune Responses

(2011) Nicolas Manel et al.   CELL

Direct Effects of Type I Interferons on Cells of the Immune System

(2011) S. Hervas-Stubbs et al.   CLINICAL CANCER RESEARCH

Virus-Induced Transient Immune Suppression and the Inhibition of T Cell Proliferation by Type I Interferon

(2011) H. D. Marshall et al.   JOURNAL OF VIROLOGY

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Innate Sensing of HIV-Infected Cells

(2011) Alice Lepelley et al.   PLoS Pathogens

Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue

(2010) Gilad Doitsh et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Immune Evasion and Counteraction of Restriction Factors by HIV-1 and Other Primate Lentiviruses

(2010) Frank Kirchhoff   Cell Host & Microbe

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics

(2010) John S. Albin et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Safety, Tolerability, and Mechanisms of Antiretroviral Activity of Pegylated Interferon Alfa‐2a in HIV‐1–Monoinfected Participants: A Phase II Clinical Trial

(2010) David M. Asmuth et al.   JOURNAL OF INFECTIOUS DISEASES

Characterization of the Alpha Interferon-Induced Postentry Block to HIV-1 Infection in Primary Human Macrophages and T Cells

(2010) C. Goujon et al.   JOURNAL OF VIROLOGY

The IFITM Proteins Inhibit HIV-1 Infection

(2010) J. Lu et al.   JOURNAL OF VIROLOGY

Analysis of Apoptosis of Memory T Cells and Dendritic Cells during the Early Stages of Viral Infection or Exposure to Toll-Like Receptor Agonists

(2010) K. Bahl et al.   JOURNAL OF VIROLOGY

Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

(2010) L. D. Harris et al.   JOURNAL OF VIROLOGY

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Interferon-Alpha Mediates Restriction of Human Immunodeficiency Virus Type-1 Replication in Primary Human Macrophages at an Early Stage of Replication

(2010) Kelly M. Cheney et al.   PLoS One

Genome-Wide mRNA Expression Correlates of Viral Control in CD4+ T-Cells from HIV-1-Infected Individuals

(2010) Margalida Rotger et al.   PLoS Pathogens

HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation

(2009) Jhen Tsang et al.   AIDS

Human Immunodeficiency Virus, Restriction Factors, and Interferon

(2009) Stuart Neil et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections

(2009) A. R. Stacey et al.   JOURNAL OF VIROLOGY

HIV Evolution in Early Infection: Selection Pressures, Patterns of Insertion and Deletion, and the Impact of APOBEC

(2009) Natasha Wood et al.   PLoS Pathogens

Emerging Concepts in the Immunopathogenesis of AIDS

(2008) Daniel C. Douek et al.   Annual Review of Medicine

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Interferon type I responses in primary and secondary infections

(2008) Mohammed Alsharifi et al.   IMMUNOLOGY AND CELL BIOLOGY

Conserved Footprints of APOBEC3G on Hypermutated Human Immunodeficiency Virus Type 1 and Human Endogenous Retrovirus HERV-K(HML2) Sequences

(2008) A. E. Armitage et al.   JOURNAL OF VIROLOGY

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Interferon signaling and treatment outcome in chronic hepatitis C

(2008) M. Sarasin-Filipowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA