Factor H–IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial PathogenStreptococcus pyogenes

Complement factor H in host defense and immune evasion

(2016) Raffaella Parente et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Using an in vitro xenoantibody-mediated complement-dependent cytotoxicity model to evaluate the complement inhibitory activity of the peptidic C3 inhibitor Cp40

(2016) Junxiang Wang et al.   CLINICAL IMMUNOLOGY

Self-nonself discrimination by the complement system

(2016) Seppo Meri   FEBS LETTERS

Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae

(2016) Sanjay Ram et al.   IMMUNOBIOLOGY

Protection of host cells by complement regulators

(2016) Christoph Q. Schmidt et al.   IMMUNOLOGICAL REVIEWS

C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend

(2016) David Ermert et al.   IMMUNOLOGY LETTERS

Complement-mediated ‘bystander’ damage initiates host NLRP3 inflammasome activation

(2016) Rahul Suresh et al.   JOURNAL OF CELL SCIENCE

A Novel Factor H–Fc Chimeric Immunotherapeutic Molecule againstNeisseria gonorrhoeae

(2016) Jutamas Shaughnessy et al.   JOURNAL OF IMMUNOLOGY

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable Haemophilus influenzae

(2016) Sandy M. Wong et al.   Frontiers in Cellular and Infection Microbiology

Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion

(2016) Elise S. Hovingh et al.   Frontiers in Microbiology

Virulence of Group A Streptococci Is Enhanced by Human Complement Inhibitors

(2015) David Ermert et al.   PLoS Pathogens

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Fusion Protein Comprising Factor H Domains 6 and 7 and Human IgG1 Fc as an Antibacterial Immunotherapeutic

(2014) Jutamas Shaughnessy et al.   Clinical and Vaccine Immunology

Update on the antibiotic resistance crisis

(2014) Gian Maria Rossolini et al.   CURRENT OPINION IN PHARMACOLOGY

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

Distinct localization of the complement C5b-9 complex on Gram-positive bacteria

(2013) Evelien T. M. Berends et al.   CELLULAR MICROBIOLOGY

Binding of Complement Inhibitor C4b-binding Protein to a Highly VirulentStreptococcus pyogenesM1 Strain Is Mediated by Protein H and Enhances Adhesion to and Invasion of Endothelial Cells

(2013) David Ermert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasmin(ogen) Acquisition by Group A Streptococcus Protects against C3b-Mediated Neutrophil Killing

(2013) Diane Ly et al.   Journal of Innate Immunity

Recommendations for the standardization of light transmission aggregometry: a consensus of the working party from the platelet physiology subcommittee of SSC/ISTH

(2013) M. Cattaneo et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Factor H Binds to the Hypervariable Region of Many Streptococcus pyogenes M Proteins but Does Not Promote Phagocytosis Resistance or Acute Virulence

(2013) Mattias C. U. Gustafsson et al.   PLoS Pathogens

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

(2012) Hongchang Qu et al.   IMMUNOBIOLOGY

Acquisition of Complement Factor H Is Important for Pathogenesis of Streptococcus pyogenes Infections: Evidence from Bacterial In Vitro Survival and Human Genetic Association

(2011) K. Haapasalo et al.   JOURNAL OF IMMUNOLOGY

Binding of the Human Complement Regulators CFHR1 and Factor H by Streptococcal Collagen-like Protein 1 (Scl1) via Their Conserved C Termini Allows Control of the Complement Cascade at Multiple Levels

(2010) Michael Reuter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement control protein factor H: The good, the bad, and the inadequate

(2010) Viviana P. Ferreira et al.   MOLECULAR IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

The Binding of Factor H to a Complex of Physiological Polyanions and C3b on Cells Is Impaired in Atypical Hemolytic Uremic Syndrome

(2009) V. P. Ferreira et al.   JOURNAL OF IMMUNOLOGY

Optimization of antibody binding to Fc RIIa enhances macrophage phagocytosis of tumor cells

(2008) J. O. Richards et al.   MOLECULAR CANCER THERAPEUTICS

Complement factor H allotype 402H is associated with increased C3b opsonization and phagocytosis ofStreptococcus pyogenes

(2008) Karita Haapasalo et al.   MOLECULAR MICROBIOLOGY