Complement-mediated ‘bystander’ damage initiates host NLRP3 inflammasome activation

The membrane attack complex as an inflammatory trigger

(2016) B. Paul Morgan   IMMUNOBIOLOGY

Dengue virus and antiplatelet autoantibodies synergistically induce haemorrhage through Nlrp3-inflammasome and FcүRIII

(2015) Chia-Ming Chang et al.   THROMBOSIS AND HAEMOSTASIS

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Complement C5a potentiates uric acid crystal-induced IL-1β production

(2014) Ling-Ling An et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

(2014) E. O. Samstad et al.   JOURNAL OF IMMUNOLOGY

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

Dramatic effects of eculizumab in a child with diffuse proliferative lupus nephritis resistant to conventional therapy

(2014) Rosanna Coppo et al.   PEDIATRIC NEPHROLOGY

Eculizumab treatment for rescue of renal function in IgA nephropathy

(2014) Therese Rosenblad et al.   PEDIATRIC NEPHROLOGY

Structural and Dynamics Aspects of ASC Speck Assembly

(2014) Ali Can Sahillioglu et al.   STRUCTURE

C3a modulates IL-1  secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

(2013) E. Asgari et al.   BLOOD

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1  Release

(2013) F. Laudisi et al.   JOURNAL OF IMMUNOLOGY

Soluble complement complex C5b-9 promotes microglia activation

(2013) Chao Yang et al.   JOURNAL OF NEUROIMMUNOLOGY

A Role for Uric Acid and the Nalp3 Inflammasome in Antiphospholipid Antibody-Induced IL-1β Production by Human First Trimester Trophoblast

(2013) Melissa J. Mulla et al.   PLoS One

Aluminum Hydroxide Adjuvant Differentially Activates the Three Complement Pathways with Major Involvement of the Alternative Pathway

(2013) Esin Güven et al.   PLoS One

Eculizumab for treatment of asthma

(2012) Steven G Smith et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH independent of its effects on hemolysis and microparticle formation

(2012) Ilene C. Weitz et al.   THROMBOSIS RESEARCH

Pathogenesis of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis

(2011) C. O. S. Savage   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis

(2011) Frank L. van de Veerdonk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration

(2011) K Lueck et al.   EYE

Platelet activation attracts a subpopulation of effector monocytes to sites ofLeishmania majorinfection

(2011) Ricardo Goncalves et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Caspase-1-Processed Cytokines IL-1  and IL-18 Promote IL-17 Production by    and CD4 T Cells That Mediate Autoimmunity

(2011) S. J. Lalor et al.   JOURNAL OF IMMUNOLOGY

Immunodeficiency and autoimmunity: lessons from systemic lupus erythematosus

(2011) Alexandros P. Grammatikos et al.   TRENDS IN MOLECULAR MEDICINE

The structure and function of mammalian membrane-attack complex/perforin-like proteins

(2010) S. C. Kondos et al.   TISSUE ANTIGENS

Complement as an Endogenous Adjuvant for Dendritic Cell-Mediated Induction of Retrovirus-Specific CTLs

(2010) Zoltán Bánki et al.   PLoS Pathogens

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production

(2009) C. Fang et al.   BLOOD

Complement-Dependent Neutrophil Recruitment Is Critical for the Development of Elastase-Induced Abdominal Aortic Aneurysm

(2009) Monica B. Pagano et al.   CIRCULATION

Complement Inhibitor Eculizumab in Atypical Hemolytic Uremic Syndrome

(2009) C. J. Mache et al.   Clinical Journal of the American Society of Nephrology

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Quantification of the infectious dose of Leishmania major transmitted to the skin by single sand flies

(2008) N. Kimblin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA