Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?
Authors
Keywords
Telomeres, Alt, Cancer therapy, G-quadruplex ligands
Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 36, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-12-22
DOI
10.1186/s13046-017-0657-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an “ALT-like” phenotype in diffuse malignant peritoneal mesothelioma cells
- (2017) Graziella Cimino-Reale et al. Journal of Hematology & Oncology
- The C-Circle Assay for alternative-lengthening-of-telomeres activity
- (2017) Jeremy D. Henson et al. METHODS
- Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes
- (2017) Jaewon Min et al. MOLECULAR AND CELLULAR BIOLOGY
- Targeting telomerase and telomeres to enhance ionizing radiation effects in in vitro and in vivo cancer models
- (2017) F. Berardinelli et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres
- (2017) Xiaolei Pan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Telomere Recognition and Assembly Mechanism of Mammalian Shelterin
- (2017) Fabian Erdel et al. Cell Reports
- Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres
- (2017) Rebecca A. Dagg et al. Cell Reports
- Cdk-dependent phosphorylation regulates TRF1 recruitment to PML bodies and promotes C-circle production in ALT cells
- (2016) Florence R. Wilson et al. JOURNAL OF CELL SCIENCE
- Patient-derived xenografts: a relevant preclinical model for drug development
- (2016) Luca Pompili et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Alternative lengthening of telomeres does exist in various canine sarcomas
- (2016) Theresa Kreilmeier et al. MOLECULAR CARCINOGENESIS
- Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds
- (2016) Jutta Zimmer et al. MOLECULAR CELL
- DNA methylation mediated up-regulation ofTERRAnon-coding RNA is coincident with elongated telomeres in the human placenta
- (2016) Boris Novakovic et al. MOLECULAR HUMAN REPRODUCTION
- Break-induced telomere synthesis underlies alternative telomere maintenance
- (2016) Robert L. Dilley et al. NATURE
- A balance between elongation and trimming regulates telomere stability in stem cells
- (2016) Teresa Rivera et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma
- (2016) Carl Koschmann et al. Science Translational Medicine
- A balance between elongation and trimming regulates telomere stability in stem cells
- (2016) Teresa Rivera et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Telomerase Regulation from Beginning to the End
- (2016) Deanna MacNeil et al. Genes
- The value of trabectedin in the treatment of soft tissue sarcoma
- (2016) Tomoki Nakamura et al. Therapeutics and Clinical Risk Management
- Leiomyosarcoma With Alternative Lengthening of Telomeres Is Associated With Aggressive Histologic Features, Loss of ATRX Expression, and Poor Clinical Outcome
- (2015) Jau-Yu Liau et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Alternative lengthening of telomeres phenotype in malignant vascular tumors is highly associated with loss of ATRX expression and is frequently observed in hepatic angiosarcomas
- (2015) Jau-Yu Liau et al. HUMAN PATHOLOGY
- Telomere length and telomerase activity in non-small cell lung cancer prognosis: clinical usefulness of a specific telomere status
- (2015) Tamara Fernández-Marcelo et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- TERRA and the state of the telomere
- (2015) Karsten Rippe et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Complex interactions between the DNA-damage response and mammalian telomeres
- (2015) Nausica Arnoult et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Molecular mechanisms of activity and derepression of alternative lengthening of telomeres
- (2015) Hilda A Pickett et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX
- (2015) David Clynes et al. Nature Communications
- TERRA and the state of the telomere
- (2015) Karsten Rippe et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Complex interactions between the DNA-damage response and mammalian telomeres
- (2015) Nausica Arnoult et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Molecular mechanisms of activity and derepression of alternative lengthening of telomeres
- (2015) Hilda A Pickett et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors
- (2014) Joshua Mangerel et al. ACTA NEUROPATHOLOGICA
- TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities
- (2014) Christian Koelsche et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities
- (2014) Angela Rizzo et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas
- (2014) Kathleen Dorris et al. JOURNAL OF NEURO-ONCOLOGY
- ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells
- (2014) David Clynes et al. PLoS One
- Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase
- (2014) Tai-Yuan Yu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells
- (2014) Rajika Arora et al. Nature Communications
- Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX Is Required for Proper Replication Restart and Cellular Resistance to Replication Stress
- (2013) Justin Wai-Chung Leung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells
- (2013) Sicong Zeng et al. JOURNAL OF CELL SCIENCE
- On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts
- (2013) Sara Iachettini et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- G-Quadruplex Structures in the Human Genome as Novel Therapeutic Targets
- (2013) Joanna Bidzinska et al. MOLECULES
- Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence
- (2013) Bettina Balk et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Human Sarcomas Are Mosaic for Telomerase-Dependent and Telomerase-Independent Telomere Maintenance Mechanisms
- (2012) April R.S. Gocha et al. AMERICAN JOURNAL OF PATHOLOGY
- The role of telomere trimming in normal telomere length dynamics
- (2012) Hilda A. Pickett et al. CELL CYCLE
- Prognostic Value of Alternative Lengthening of Telomeres–Associated Biomarkers in Uterine Sarcoma and Uterine Carcinosarcoma
- (2012) Yoo-Kyung Lee et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Compromised genomic integrity impedes muscle growth after Atrx inactivation
- (2012) Michael S. Huh et al. JOURNAL OF CLINICAL INVESTIGATION
- Telomere loss, not average telomere length, confers radiosensitivity to TK6-irradiated cells
- (2012) F. Berardinelli et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
- (2012) Jeremy Schwartzentruber et al. NATURE
- Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway
- (2012) Courtney A. Lovejoy et al. PLoS Genetics
- Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes
- (2011) Christopher M. Heaphy et al. AMERICAN JOURNAL OF PATHOLOGY
- DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents
- (2011) A. Biroccio et al. CLINICAL CANCER RESEARCH
- Human Mre11/Human Rad50/Nbs1 and DNA Ligase IIIα/XRCC1 Protein Complexes Act Together in an Alternative Nonhomologous End Joining Pathway
- (2011) Julie Della-Maria et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The alternative lengthening of telomeres pathway may operate in non-neoplastic human cells
- (2011) Tania L Slatter et al. JOURNAL OF PATHOLOGY
- Altered Telomeres in Tumors with ATRX and DAXX Mutations
- (2011) C. M. Heaphy et al. SCIENCE
- Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis
- (2010) Lorenza Venturini et al. BMC CANCER
- Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers
- (2010) Jeremy D. Henson et al. FEBS LETTERS
- Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival
- (2010) Kerrie L. McDonald et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- A Review of Trabectedin (ET-743): A Unique Mechanism of Action
- (2010) Maurizio D'Incalci et al. MOLECULAR CANCER THERAPEUTICS
- Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths
- (2010) Masayuki Kimura et al. Nature Protocols
- Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
- (2009) Angela Rizzo et al. NUCLEIC ACIDS RESEARCH
- Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies
- (2008) Jennie N. Jeyapalan et al. INTERNATIONAL JOURNAL OF CANCER
- Immunohistochemical expression of promyelocytic leukemia body in soft tissue sarcomas
- (2008) Toshihiro Matsuo et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Alternative lengthening of telomeres (ALT) and chromatin: Is there a connection?
- (2007) Thalia Nittis et al. BIOCHIMIE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now