miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an “ALT-like” phenotype in diffuse malignant peritoneal mesothelioma cells

Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

(2017) Rihan El Bezawy et al.   Journal of Hematology & Oncology

Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors

(2016) Aatur D. Singhi et al.   CLINICAL CANCER RESEARCH

Telomerase inhibitors: a patent review (2010–2015)

(2016) Ruo-Jun Man et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma

(2016) Virginia Spanò et al.   JOURNAL OF MEDICINAL CHEMISTRY

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

(2016) Mohammad A. Jafri et al.   Genome Medicine

Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells

(2015) Mahesh Ramamoorthy et al.   CANCER CELL

miR-1182 attenuates gastric cancer proliferation and metastasis by targeting the open reading frame of hTERT

(2015) Dan Zhang et al.   CANCER LETTERS

Comprehensive screening of alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas

(2015) Jau-Yu Liau et al.   MODERN PATHOLOGY

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

(2015) Hilda A Pickett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

(2015) Hilda A Pickett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells

(2015) Takahito Ohira et al.   Scientific Reports

miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively

(2015) Ge Song et al.   Scientific Reports

The panorama of miRNA-mediated mechanisms in mammalian cells

(2014) Anna Stroynowska-Czerwinska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MicroRNA-dependent Regulation of Telomere Maintenance Mechanisms: A Field as Much Unexplored as Potentially Promising

(2014) Francesca Santambrogio et al.   CURRENT PHARMACEUTICAL DESIGN

miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ

(2014) Hyun Jung et al.   Molecular Cancer

Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

(2014) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Diffuse malignant peritoneal mesothelioma: Long-term survival with complete cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC)

(2013) Dario Baratti et al.   EUROPEAN JOURNAL OF CANCER

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

(2012) Jian Hu et al.   CELL

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

(2012) Marilena V. Iorio et al.   EMBO Molecular Medicine

Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance

(2012) L. Venturini et al.   NEURO-ONCOLOGY

Cancer and Telomeres--An ALTernative to Telomerase

(2012) J. W. Shay et al.   SCIENCE

miRWalk – Database: Prediction of possible miRNA binding sites by “walking” the genes of three genomes

(2011) Harsh Dweep et al.   JOURNAL OF BIOMEDICAL INFORMATICS

The role of microRNA-150 as a tumor suppressor in malignant lymphoma

(2011) A Watanabe et al.   LEUKEMIA

MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region

(2011) A.-r. Yoon et al.   NUCLEIC ACIDS RESEARCH

TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21WAF1/Cip1 and PTEN/AKT pathway

(2010) Eun Jin Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alternative lengthening of telomeres in hTERT-inhibited laryngeal cancer cells

(2010) Wei Chen et al.   CANCER SCIENCE

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers

(2010) Jeremy D. Henson et al.   FEBS LETTERS

TSPYL5 suppresses p53 levels and function by physical interaction with USP7

(2010) Mirjam T. Epping et al.   NATURE CELL BIOLOGY

miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma

(2010) Alexander Swarbrick et al.   NATURE MEDICINE

Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths

(2010) Masayuki Kimura et al.   Nature Protocols

Experience with peritoneal mesothelioma at the Milan National Cancer Institute

(2010) Marcello Deraco   World Journal of Gastrointestinal Oncology

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

(2009) Jeremy D Henson et al.   NATURE BIOTECHNOLOGY

Multiple Mechanisms of Telomere Maintenance Exist and Differentially Affect Clinical Outcome in Diffuse Malignant Peritoneal Mesothelioma

(2008) R. Villa et al.   CLINICAL CANCER RESEARCH