Patient-derived xenografts: a relevant preclinical model for drug development

Humanized Mouse Xenograft Models: Narrowing the Tumor–Microenvironment Gap

(2016) J. Jason Morton et al.   CANCER RESEARCH

Regorafenib for the Treatment of Advanced Gastric Cancer (INTEGRATE): A Multinational Placebo-Controlled Phase II Trial

(2016) Nick Pavlakis et al.   JOURNAL OF CLINICAL ONCOLOGY

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

(2016) Danny N. Khalil et al.   Nature Reviews Clinical Oncology

Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy

(2016) Yukihiko Hiroshima et al.   Oncotarget

Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts

(2015) Matthew Read et al.   ANNALS OF SURGICAL ONCOLOGY

Color-coding cancer and stromal cells with genetic reporters in a patient-derived orthotopic xenograft (PDOX) model of pancreatic cancer enhances fluorescence-guided surgery

(2015) S Yano et al.   CANCER GENE THERAPY

Evaluating Patient-Derived Colorectal Cancer Xenografts as Preclinical Models by Comparison with Patient Clinical Data

(2015) M. Nunes et al.   CANCER RESEARCH

Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies

(2015) C. Krepler et al.   CLINICAL CANCER RESEARCH

Antitumor activity of the multikinase inhibitor regorafenib in patient-derived xenograft models of gastric cancer

(2015) Hung Huynh et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

MicroPET/CT imaging of patient-derived pancreatic cancer xenografts implanted subcutaneously or orthotopically in NOD-scid mice using 64Cu-NOTA-panitumumab F(ab')2 fragments

(2015) Amanda J. Boyle et al.   NUCLEAR MEDICINE AND BIOLOGY

Initiation and Characterization of Small Cell Lung Cancer Patient-Derived Xenografts from Ultrasound-Guided Transbronchial Needle Aspirates

(2015) Wade C. Anderson et al.   PLoS One

Establishing prostate cancer patient derived xenografts: Lessons learned from older studies

(2015) Pamela J. Russell et al.   PROSTATE

Patient-derived bladder cancer xenografts: a systematic review

(2015) Carina Bernardo et al.   Translational Research

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers

(2015) Sandra Misale et al.   Nature Communications

Appropriateness of Using Patient-Derived Xenograft Models for Pharmacologic Evaluation of Novel Therapies for Esophageal/Gastro-Esophageal Junction Cancers

(2015) Lorin Dodbiba et al.   PLoS One

Patient-Derived Ovarian Tumor Xenografts Recapitulate Human Clinicopathology and Genetic Alterations

(2014) F. Ricci et al.   CANCER RESEARCH

A comprehensively characterized large panel of head and neck cancer patient-derived xenografts identifies the mTOR inhibitor everolimus as potential new treatment option

(2014) Konrad Klinghammer et al.   INTERNATIONAL JOURNAL OF CANCER

Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- and phenotypes of patient tumours

(2014) Noémie Braekeveldt et al.   INTERNATIONAL JOURNAL OF CANCER

The multiple facets of drug resistance: one history, different approaches

(2014) Evandro Niero et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Efficacy and safety of ipilimumab in elderly patients with pretreated advanced melanoma treated at Italian centres through the expanded access programme

(2014) Vanna Chiarion Sileni et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor

(2014) Jason K Sicklick et al.   Journal of Translational Medicine

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts

(2014) Monique D. Topp et al.   Molecular Oncology

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models

(2013) X. Zhang et al.   CANCER RESEARCH

Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models

(2013) D. Siolas et al.   CANCER RESEARCH

Hand-held high-resolution fluorescence imaging system for fluorescence-guided surgery of patient and cell-line pancreatic tumors growing orthotopically in nude mice

(2013) Yukihiko Hiroshima et al.   JOURNAL OF SURGICAL RESEARCH

Establishment of patient-derived non-small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies

(2013) Xu-chao Zhang et al.   Journal of Translational Medicine

Clinical, Molecular and Genetic Validation of a Murine Orthotopic Xenograft Model of Pancreatic Adenocarcinoma Using Fresh Human Specimens

(2013) Dustin M. Walters et al.   PLoS One

The tumor microenvironment controls drug sensitivity

(2012) Arne Östman   NATURE MEDICINE

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma

(2012) Xiumei Zhao et al.   NEURO-ONCOLOGY

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

High drug attrition rates—where are we going wrong?

(2011) Lisa Hutchinson et al.   Nature Reviews Clinical Oncology

A Molecularly Annotated Platform of Patient-Derived Xenografts ("Xenopatients") Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

(2011) A. Bertotti et al.   Cancer Discovery

Establishment and Characterization of a Panel of Human Uveal Melanoma Xenografts Derived from Primary and/or Metastatic Tumors

(2010) F. Nemati et al.   CLINICAL CANCER RESEARCH

The Ability to Form Primary Tumor Xenografts Is Predictive of Increased Risk of Disease Recurrence in Early-Stage Non-Small Cell Lung Cancer

(2010) T. John et al.   CLINICAL CANCER RESEARCH

Recent advances of novel targeted therapy in non-small cell lung cancer

(2009) Jed A Katzel et al.   Journal of Hematology & Oncology

Establishment of Patient-Derived Non-Small Cell Lung Cancer Xenografts as Models for the Identification of Predictive Biomarkers

(2008) I. Fichtner et al.   CLINICAL CANCER RESEARCH