Complex interactions between the DNA-damage response and mammalian telomeres

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding

(2015) Grzegorz Sarek et al.   MOLECULAR CELL

Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients

(2015) K. Simpson et al.   Molecular Oncology

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection

(2015) Vera Boersma et al.   NATURE

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Cell death during crisis is mediated by mitotic telomere deprotection

(2015) Makoto T. Hayashi et al.   NATURE

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates

(2015) Jaya Sarkar et al.   NUCLEIC ACIDS RESEARCH

Human Rap1 modulates TRF2 attraction to telomeric DNA

(2015) Eliška Janoušková et al.   NUCLEIC ACIDS RESEARCH

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA double strand break repair pathway choice: a chromatin based decision?

(2015) T Clouaire et al.   Nucleus

DNA double strand break repair pathway choice: a chromatin based decision?

(2015) T Clouaire et al.   Nucleus

TRF1 and TRF2 Differentially Modulate Rad51-Mediated Telomeric and Nontelomeric Displacement Loop Formation in Vitro

(2014) Brian D. Bower et al.   BIOCHEMISTRY

The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres

(2014) Adélaïde Saint-Léger et al.   CELL CYCLE

DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells

(2014) Sehyun Oh et al.   DNA REPAIR

Alternative end-joining pathway(s): Bricolage at DNA breaks

(2014) Philippe Frit et al.   DNA REPAIR

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

(2014) Michal Zimmermann et al.   GENES & DEVELOPMENT

Germline Mutations in Shelterin Complex Genes Are Associated With Familial Glioma

(2014) Matthew N. Bainbridge et al.   JNCI-Journal of the National Cancer Institute

POT1 loss-of-function variants predispose to familial melanoma

(2014) Carla Daniela Robles-Espinoza et al.   NATURE GENETICS

Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma

(2014) Jianxin Shi et al.   NATURE GENETICS

Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions

(2014) A. Orthwein et al.   SCIENCE

Functional characterization of the TERRA transcriptome at damaged telomeres

(2014) Antonio Porro et al.   Nature Communications

Escape from Telomere-Driven Crisis Is DNA Ligase III Dependent

(2014) Rhiannon E. Jones et al.   Cell Reports

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

(2014) Antonio Porro et al.   Cell Reports

TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation

(2014) Shaheen Kabir et al.   Cell Reports

Isolation of Chromatin from Dysfunctional Telomeres Reveals an Important Role for Ring1b in NHEJ-Mediated Chromosome Fusions

(2014) Cristina Bartocci et al.   Cell Reports

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

(2014) Matthew J. Yousefzadeh et al.   PLoS Genetics

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

5′ C-rich telomeric overhangs are an outcome of rapid telomere truncation events

(2013) Liana Oganesian et al.   DNA REPAIR

Extensive Telomere Erosion in the Initiation of Colorectal Adenomas and Its Association With Chromosomal Instability

(2013) Laureline Roger et al.   JNCI-Journal of the National Cancer Institute

The Telomere Deprotection Response Is Functionally Distinct from the Genomic DNA Damage Response

(2013) Anthony J. Cesare et al.   MOLECULAR CELL

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A two-step mechanism for TRF2-mediated chromosome-end protection

(2013) Keiji Okamoto et al.   NATURE

POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia

(2013) Andrew J Ramsay et al.   NATURE GENETICS

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication

(2013) J.-B. Vannier et al.   SCIENCE

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

(2013) M. Di Virgilio et al.   SCIENCE

TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres

(2013) Albert Ribes-Zamora et al.   Cell Reports

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres

(2013) Bingbing Wan et al.   Cell Reports

Localization-Dependent and -Independent Roles of SLX4 in Regulating Telomeres

(2013) Jamie S.J. Wilson et al.   Cell Reports

Telomere-Driven Tetraploidization Occurs in Human Cells Undergoing Crisis and Promotes Transformation of Mouse Cells

(2012) Teresa Davoli et al.   CANCER CELL

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST

(2012) Peng Wu et al.   CELL

A three-state model of telomere control over human proliferative boundaries

(2012) Anthony J Cesare et al.   CURRENT OPINION IN CELL BIOLOGY

Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening

(2012) T. T. Chow et al.   GENES & DEVELOPMENT

Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the Telomere

(2012) N. Özlem Arat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

(2012) Makoto T Hayashi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α

(2012) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction

(2012) Sehyun Oh et al.   NUCLEIC ACIDS RESEARCH

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Five dysfunctional telomeres predict onset of senescence in human cells

(2011) Zeenia Kaul et al.   EMBO REPORTS

Telomere Protection by TPP1/POT1 Requires Tethering to TIN2

(2011) Kaori K. Takai et al.   MOLECULAR CELL

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms

(2011) Yong Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection

(2011) Rekha Rai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis

(2010) T. T. Lin et al.   BLOOD

Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy

(2010) Teresa Davoli et al.   CELL

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

(2010) Jing Ye et al.   CELL

Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection

(2010) Xueyu Dai et al.   EMBO JOURNAL

The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres

(2010) Rekha Rai et al.   EMBO JOURNAL

SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair

(2010) Yung C Lam et al.   EMBO JOURNAL

A Shld1-Controlled POT1a Provides Support for Repression of ATR Signaling at Telomeres through RPA Exclusion

(2010) Yi Gong et al.   MOLECULAR CELL

Apollo Contributes to G Overhang Maintenance and Protects Leading-End Telomeres

(2010) Peng Wu et al.   MOLECULAR CELL

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

(2010) Sophie Badie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson syndrome

(2010) F. Touzot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Control of telomere length by a trimming mechanism that involves generation of t-circles

(2009) Hilda A Pickett et al.   EMBO JOURNAL

Human RAP1 inhibits non-homologous end joining at telomeres

(2009) Jay Sarthy et al.   EMBO JOURNAL

Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN

(2009) N. Arnoult et al.   GENES & DEVELOPMENT

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

(2009) Anthony J Cesare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements

(2009) Boitelo T. Letsolo et al.   NUCLEIC ACIDS RESEARCH

Ku86 represses lethal telomere deletion events in human somatic cells

(2009) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered telomere degradation models dyskeratosis congenita

(2008) D. Hockemeyer et al.   GENES & DEVELOPMENT

Functional Dissection of Human and Mouse POT1 Proteins

(2008) W. Palm et al.   MOLECULAR AND CELLULAR BIOLOGY

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE

A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins

(2008) Y. Chen et al.   SCIENCE

Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy

(2008) Xueying Wang et al.   Epigenetics & Chromatin