CDK2 Regulates HIV-1 Transcription by Phosphorylation of CDK9 on Serine 90

Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4+ T cells and inhibits HIV-1 gene expression

(2012) Sona Budhiraja et al.   Retrovirology

Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR

(2012) Mirai Nakamura et al.   Retrovirology

CTGC motifs within the HIV core promoter specify Tat-responsive pre-initiation complexes

(2012) Emmanuelle Wilhelm et al.   Retrovirology

Switching Cdk2 On or Off with Small Molecules to Reveal Requirements in Human Cell Proliferation

(2011) Karl A. Merrick et al.   MOLECULAR CELL

Protein Phosphatase-1 Activates CDK9 by Dephosphorylating Ser175

(2011) Tatiana Ammosova et al.   PLoS One

Latency profiles of full length HIV-1 molecular clone variants with a subtype specific promoter

(2011) Renée M van der Sluis et al.   Retrovirology

Cyclin-dependent kinase inhibitors: a survey of recent patent literature

(2010) Hervé Galons et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Expression of a Protein Phosphatase 1 Inhibitor, cdNIPP1, Increases CDK9 Threonine 186 Phosphorylation and Inhibits HIV-1 Transcription

(2010) Tatiana Ammosova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells

(2010) U Kruse et al.   LEUKEMIA

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

(2010) Nanhai He et al.   MOLECULAR CELL

HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP

(2010) Bijan Sobhian et al.   MOLECULAR CELL

Iron Chelators of the Di-2-pyridylketone Thiosemicarbazone and 2-Benzoylpyridine Thiosemicarbazone Series Inhibit HIV-1 Transcription: Identification of Novel Cellular Targets--Iron, Cyclin-Dependent Kinase (CDK) 2, and CDK9

(2010) Z. Debebe et al.   MOLECULAR PHARMACOLOGY

Crystal structure of HIV-1 Tat complexed with human P-TEFb

(2010) Tahir H. Tahirov et al.   NATURE

HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear

(2010) Iván D’Orso et al.   Viruses-Basel

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

(2009) M. Barboric et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes

(2008) Andreas Markert et al.   EMBO REPORTS

PP2B and PP1  cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling

(2008) R. Chen et al.   GENES & DEVELOPMENT

Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop

(2008) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A La-Related Protein Modulates 7SK snRNP Integrity to Suppress P-TEFb-Dependent Transcriptional Elongation and Tumorigenesis

(2008) Nanhai He et al.   MOLECULAR CELL

LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated

(2008) B. J. Krueger et al.   NUCLEIC ACIDS RESEARCH