Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma

Integrated genomic characterization of adrenocortical carcinoma

(2014) Guillaume Assié et al.   NATURE GENETICS

Laf4/Aff3, a Gene Involved in Intellectual Disability, Is Required for Cellular Migration in the Mouse Cerebral Cortex

(2014) Justin M. Moore et al.   PLoS One

An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription

(2014) M. Giraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FRA2A Is a CGG Repeat Expansion Associated with Silencing of AFF3

(2014) Sofie Metsu et al.   PLoS Genetics

Wnt signaling in stem and cancer stem cells

(2013) Jane D Holland et al.   CURRENT OPINION IN CELL BIOLOGY

Pharmacological modulation of beta-catenin and its applications in cancer therapy

(2013) Ravi Thakur et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ARMC5 Mutations in Macronodular Adrenal Hyperplasia with Cushing's Syndrome

(2013) Guillaume Assié et al.   NEW ENGLAND JOURNAL OF MEDICINE

Silencing Mutated β-Catenin Inhibits Cell Proliferation and Stimulates Apoptosis in the Adrenocortical Cancer Cell Line H295R

(2013) Sébastien Gaujoux et al.   PLoS One

Progression to Adrenocortical Tumorigenesis in Mice and Humans through Insulin-Like Growth Factor 2 and β-Catenin

(2012) Joanne H. Heaton et al.   AMERICAN JOURNAL OF PATHOLOGY

On the role of Wnt/β-catenin signaling in stem cells

(2012) Susanne J. Kühl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes

(2012) Chris Wallace et al.   HUMAN MOLECULAR GENETICS

The Super Elongation Complex Family of RNA Polymerase II Elongation Factors: Gene Target Specificity and Transcriptional Output

(2012) Z. Luo et al.   MOLECULAR AND CELLULAR BIOLOGY

Combination Chemotherapy in Advanced Adrenocortical Carcinoma

(2012) Martin Fassnacht et al.   NEW ENGLAND JOURNAL OF MEDICINE

New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes

(2012) Niina Sandholm et al.   PLoS Genetics

Genome-wide association study of rheumatoid arthritis in Koreans: Population-specific loci as well as overlap with European susceptibility loci

(2011) Jan Freudenberg et al.   ARTHRITIS AND RHEUMATISM

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

The Genetic Basis of Graves Disease

(2011) Rafal Ploski et al.   CURRENT GENOMICS

The super elongation complex (SEC) and MLL in development and disease

(2011) E. Smith et al.   GENES & DEVELOPMENT

Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability

(2011) Mireille Melko et al.   HUMAN MOLECULAR GENETICS

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers

(2010) D. Plant et al.   ANNALS OF THE RHEUMATIC DISEASES

Transcriptome Analysis Reveals that p53 and  -Catenin Alterations Occur in a Group of Aggressive Adrenocortical Cancers

(2010) B. Ragazzon et al.   CANCER RESEARCH

 -Catenin Activation Is Associated with Specific Clinical and Pathologic Characteristics and a Poor Outcome in Adrenocortical Carcinoma

(2010) S. Gaujoux et al.   CLINICAL CANCER RESEARCH

Constitutive β-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development

(2010) Annabel Berthon et al.   HUMAN MOLECULAR GENETICS

Wnt/β-Catenin Pathway Activation in Adrenocortical Adenomas Is Frequently due to Somatic CTNNB1-Activating Mutations, Which Are Associated with Larger and Nonsecreting Tumors: A Study in Cortisol-Secreting and -Nonsecreting Tumors

(2010) Stéphane Bonnet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

Wnt/βcatenin signaling in adrenocortical stem/progenitor cells: Implications for adrenocortical carcinoma

(2009) A. Kim et al.   ANNALES D ENDOCRINOLOGIE

Inactivation of the Carney Complex Gene 1 (Protein Kinase A Regulatory Subunit 1A) Inhibits SMAD3 Expression and TGF -Stimulated Apoptosis in Adrenocortical Cells

(2009) B. Ragazzon et al.   CANCER RESEARCH

Triangular tibia with fibular aplasia associated with a microdeletion on 2q11.2 encompassing LAF4

(2009) E Steichen-Gersdorf et al.   CLINICAL GENETICS

Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes

(2009) Anne Barton et al.   HUMAN MOLECULAR GENETICS

Targeted disruption of  -catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex

(2008) A. C. Kim et al.   DEVELOPMENT

The T cell factor/β-Catenin Antagonist PKF115–584 Inhibits Proliferation of Adrenocortical Carcinoma Cells

(2008) Mabrouka Doghman et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Wnt/β-Catenin and 3′,5′-Cyclic Adenosine 5′-Monophosphate/Protein Kinase A Signaling Pathways Alterations and Somatic β-Catenin Gene Mutations in the Progression of Adrenocortical Tumors

(2008) Sébastien Gaujoux et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM