Journal
EUROPEAN JOURNAL OF HEART FAILURE
Volume 17, Issue 11, Pages 1091-1103Publisher
WILEY
DOI: 10.1002/ejhf.399
Keywords
Heart failure; cell-cell communication; inter-organ communication; paracrine signalling mediators
Categories
Funding
- Integrated Research and Treatment Centre, BMBF
- Deutsche Forschungsgemeinschaft [DFG TH903/10-1]
- 7th European Framework programme (FIBROTARGET)
- HRCMM (Heidelberg Research Centre for Molecular Medicine) Career Development Fellowship
- European Commission 7th Framework Programme (EUTrigTreat)
- Telethon Foundation [GGP11224]
- Swedish Research Council
- Swedish Heart and Lung Foundation
- Diabetes Foundation
- Karolinska Institutet
- Swedish Society for Medical Research
- EMBO Longterm Fellowship
- European Commission (EMBOCOFUND) - Marie Curie Actions [GA-210-267146]
- European Commission (FP7-Health) [MEDIA-261409]
- British Heart Foundation [PG/13/56/30383]
- Oxford Biomedical Research Council
- Marie Curie Intra-European Fellowship by the European Commission within FP7 (HRS-EAT) [300289]
- Deutsche Forschungsgemeinschaft DFG [SP-1293/1-1]
- European Commission7th Framework Programme (SysKid)
- Else-Kroener-Fresenius foundation
- British Heart Foundation [FS/11/66/28855, PG/13/56/30383] Funding Source: researchfish
Ask authors/readers for more resources
Cell-cell or inter-organ communication allows the exchange of information and messages, which is essential for the coordination of cell/organ functions and the maintenance of homeostasis. It has become evident that dynamic interactions of different cell types play a major role in the heart, in particular during the progression of heart failure, a leading cause of mortality worldwide. Heart failure is associated with compensatory structural and functional changes mostly in cardiomyocytes and cardiac fibroblasts, which finally lead to cardiomyocyte hypertrophy and fibrosis. Intercellular communication within the heart is mediated mostly via direct cell-cell interaction or the release of paracrine signalling mediators such as cytokines and chemokines. However, recent studies have focused on the exchange of genetic information via the packaging into vesicles as well as the crosstalk of lipids and other paracrine molecules within the heart and distant organs, such as kidney and adipose tissue, which might all contribute to the pathogenesis of heart failure. In this review, we discuss emerging communication networks and respective underlying mechanisms which could be involved in cardiovascular disease conditions and further emphasize promising therapeutic targets for drug development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available