Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance

A Salt Bridge in Intracellular Loop 2 Is Essential for Folding of Human P-Glycoprotein

(2013) Tip W. Loo et al.   BIOCHEMISTRY

Association/Dissociation of the Nucleotide-binding Domains of the ATP-binding Cassette Protein MsbA Measured during Continuous Hydrolysis

(2013) Rebecca S. Cooper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the Origin of Large Flexibility of P-glycoprotein in the Inward-facing State

(2013) Po-Chao Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric Coupling between the Intracellular Coupling Helix 4 and Regulatory Sites of the First Nucleotide-binding Domain of CFTR

(2013) Jennifer E. Dawson et al.   PLoS One

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

(2013) A. B. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P-glycoprotein is fully active after multiple tryptophan substitutions

(2012) Douglas J. Swartz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The ATPase Activity of the P-glycoprotein Drug Pump Is Highly Activated When the N-terminal and Central Regions of the Nucleotide-binding Domains Are Linked Closely Together

(2012) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Ligand-induced Conformational Rearrangements in P-glycoprotein as Probed by Fluorescence Resonance Energy Transfer Spectroscopy

(2011) Brandy Verhalen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Differences in Pore Properties Between Wild-Type and Cysteine-Less Forms of the CFTR Chloride Channel

(2011) Ryan G. Holstead et al.   JOURNAL OF MEMBRANE BIOLOGY

A Gene Optimization Strategy that Enhances Production of Fully Functional P-Glycoprotein in Pichia pastoris

(2011) Jiangping Bai et al.   PLoS One

The V510D Suppressor Mutation Stabilizes ΔF508-CFTR at the Cell Surface

(2010) Tip W. Loo et al.   BIOCHEMISTRY

Spin labeling of the Escherichia coli NADH ubiquinone oxidoreductase (complex I)

(2010) Thomas Pohl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1

(2010) Emily Crowley et al.   FEBS Journal

ABC Efflux Pump-Based Resistance to Chemotherapy Drugs

(2009) Paul D. W. Eckford et al.   CHEMICAL REVIEWS

Functional role of the linker region in purified human P-glycoprotein

(2009) Tomomi Sato et al.   FEBS Journal

Improved expression and purification of human multidrug resistance protein MDR1 from baculovirus-infected insect cells

(2009) Atsushi Kodan et al.   PROTEIN EXPRESSION AND PURIFICATION

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1

(2009) Daniel A.P. Gutmann et al.   TRENDS IN BIOCHEMICAL SCIENCES