Involvement of the Warburg effect in non-tumor diseases processes

Inflammation in atherosclerosis

(2016) Soraya Taleb   Archives of Cardiovascular Diseases

Endothelial cell metabolism: A novel player in atherosclerosis? Basic principles and therapeutic opportunities

(2016) Andreas Pircher et al.   ATHEROSCLEROSIS

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo

(2016) Siroon Bekkering et al.   ATHEROSCLEROSIS

Disruption of Glut1 in Hematopoietic Stem Cells Prevents Myelopoiesis and Enhanced Glucose Flux in Atheromatous Plaques ofApoE−/−MiceNovelty and Significance

(2016) Vincent Sarrazy et al.   CIRCULATION RESEARCH

Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis

(2016) Xiao-Qing Sun et al.   HYPERTENSION RESEARCH

Oligodendrogliopathy in Multiple Sclerosis: Low Glycolytic Metabolic Rate Promotes Oligodendrocyte Survival

(2016) M. B. Rone et al.   JOURNAL OF NEUROSCIENCE

Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism

(2016) Naoyuki Makita et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

A Urinary Metabolic Signature for Multiple Sclerosis and Neuromyelitis Optica

(2016) Teklab Gebregiworgis et al.   JOURNAL OF PROTEOME RESEARCH

Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease

(2016) Meliana Riwanto et al.   PLoS One

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A PKM2 signature in the failing heart

(2015) Meredith L. Rees et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucose-6-phosphate tips the balance in modulating apoptosis in cerebellar granule cells

(2015) A. Bobba et al.   FEBS LETTERS

Bioenergetics profile of CD4 + T cells in relapsing remitting multiple sclerosis subjects

(2015) Lidia De Riccardis et al.   JOURNAL OF BIOTECHNOLOGY

MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

(2015) Mireille Ouimet et al.   JOURNAL OF CLINICAL INVESTIGATION

2-Deoxy-D-Glucose Ameliorates PKD Progression

(2015) M. Chiaravalli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs

(2015) Lanbo Shi et al.   Scientific Reports

Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells

(2015) Ruslan Rafikov et al.   Redox Biology

Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions

(2015) Philip G. Nijland et al.   Acta Neuropathologica Communications

Glycolytic enzyme upregulation and numbness of mitochondrial activity characterize the early phase of apoptosis in cerebellar granule cells

(2014) A. Bobba et al.   APOPTOSIS

A genetic perspective on glucose consumption in the cerebral cortex during human development

(2014) J. Caravas et al.   DIABETES OBESITY & METABOLISM

Cutting Edge: Vitamin D Regulates Lipid Metabolism in Mycobacterium tuberculosis Infection

(2014) H. Salamon et al.   JOURNAL OF IMMUNOLOGY

Glycolytic inhibitor 2-deoxy-d-glucose suppresses cell proliferation and enhances methylprednisolone sensitivity in non-Hodgkin lymphoma cells through down-regulation of HIF-1α and c-MYC

(2014) Yu-Yang Pang et al.   LEUKEMIA & LYMPHOMA

Increased Metabolite Levels of Glycolysis and Pentose Phosphate Pathway in Rabbit Atherosclerotic Arteries and Hypoxic Macrophage

(2014) Atsushi Yamashita et al.   PLoS One

Enhanced Antitumor Immunity Contributes to the Radio-Sensitization of Ehrlich Ascites Tumor by the Glycolytic Inhibitor 2-Deoxy-D-Glucose in Mice

(2014) Abdullah Farooque et al.   PLoS One

The Warburg effect then and now: From cancer to inflammatory diseases

(2013) Eva M. Palsson-McDermott et al.   BIOESSAYS

Metabolic dysfunction in pulmonary hypertension: the expanding relevance of the Warburg effect

(2013) Katherine A. Cottrill et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy

(2013) Isaline Rowe et al.   NATURE MEDICINE

Influence of glucose metabolism on vascular smooth muscle cell proliferation

(2013) Mario Chiong et al.   Vasa-European Journal of Vascular Medicine

Lactic Acid Is Elevated in Idiopathic Pulmonary Fibrosis and Induces Myofibroblast Differentiation via pH-Dependent Activation of Transforming Growth Factor-β

(2012) Robert Matthew Kottmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid β and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production

(2012) Jordan T. Newington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate

(2012) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

(2012) Haitao Wen et al.   NATURE IMMUNOLOGY

New aspects of the Warburg effect in cancer cell biology

(2012) Steven J. Bensinger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Metabolomic Analysis of Bone Morphogenetic Protein Receptor Type 2 Mutations in Human Pulmonary Endothelium Reveals Widespread Metabolic Reprogramming

(2012) Joshua P. Fessel et al.   Pulmonary Circulation

Current therapeutics and practical management strategies for pulmonary arterial hypertension

(2011) Richa Agarwal et al.   AMERICAN HEART JOURNAL

Targeting Energetic Metabolism

(2011) Rubin M. Tuder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Role of Pyruvate Dehydrogenase Inhibition in the Development of Hypertrophy in the Hyperthyroid Rat Heart

(2011) Helen J. Atherton et al.   CIRCULATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic Profiling of Lung Granuloma inMycobacterium tuberculosisInfected Guinea Pigs: Ex vivo1H Magic Angle Spinning NMR Studies

(2011) B. S. Somashekar et al.   JOURNAL OF PROTEOME RESEARCH

Mechanisms of disease: hypertrophic cardiomyopathy

(2011) Norbert Frey et al.   Nature Reviews Cardiology

Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect

(2011) Jordan T. Newington et al.   PLoS One

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Impairment of mitochondrial respiration in mouse fibroblasts byoncogenic H-RASQ61L

(2010) Dianer Yang et al.   CANCER BIOLOGY & THERAPY

Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension

(2010) G. Sutendra et al.   Science Translational Medicine

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

(2009) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Polycystic Kidney Disease

(2009) J. Benun et al.   PEDIATRICS IN REVIEW

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER