A Mini-Review of Reactive Oxygen Species in Urological Cancer: Correlation with NADPH Oxidases, Angiogenesis, and Apoptosis

Anethole Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Apoptosis

(2018) Ayman I. Elkady   Anti-Cancer Agents in Medicinal Chemistry

Potential Molecular Targets of Ampelopsin in Prevention and Treatment of Cancers

(2018) Xianjuan Kou et al.   Anti-Cancer Agents in Medicinal Chemistry

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer

(2018) Luka Andrisic et al.   Redox Biology

Paradoxical roles of dual oxidases in cancer biology

(2017) Andrew C. Little et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of Oxidants Distinguishes Susceptibility of Prostate Carcinoma Cell Lines to p53 Gene Transfer Mediated by an Improved Adenoviral Vector

(2017) Rodrigo Esaki Tamura et al.   HUMAN GENE THERAPY

Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells

(2017) Kwang-Youn Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bax/Bak-independent mitochondrial depolarization and reactive oxygen species induction by sorafenib overcome resistance to apoptosis in renal cell carcinoma

(2017) Bernhard Gillissen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination of Carmustine and Selenite Inhibits EGFR Mediated Growth Signaling in Androgen-Independent Prostate Cancer Cells

(2017) Vijayalakshmi Thamilselvan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Naringenin-Induced Apoptotic Cell Death in Prostate Cancer Cells Is Mediated via the PI3K/AKT and MAPK Signaling Pathways

(2017) Whasun Lim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Anti-Tumorigenic Potential of a Novel Orlistat-AICAR Combination in Prostate Cancer Cells

(2017) Clayton Wright et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Chrysin induces death of prostate cancer cells by inducing ROS and ER stress

(2017) Soomin Ryu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NADPH Oxidase-1 Plays a Key Role in Keratinocyte Responses to UV Radiation and UVB-Induced Skin Carcinogenesis

(2017) Houssam Raad et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

NOX2-dependent immunosuppression in chronic myelomonocytic leukemia

(2017) Johan Aurelius et al.   JOURNAL OF LEUKOCYTE BIOLOGY

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

(2017) Yang Zhao et al.   Molecular Cancer

Oxidative Stress: Harms and Benefits for Human Health

(2017) Gabriele Pizzino et al.   Oxidative Medicine and Cellular Longevity

Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells

(2017) Sul-Gi Park et al.   Pharmacological Reports

Benzyl isothiocyanate induces reactive oxygen species-initiated autophagy and apoptosis in human prostate cancer cells

(2017) Ji-Fan Lin et al.   Oncotarget

Reduction–oxidation pathways involved in cancer development: a systematic review of literature reviews

(2017) Xīn Gào et al.   Oncotarget

Role of NOX2-Derived Reactive Oxygen Species in NK Cell–Mediated Control of Murine Melanoma Metastasis

(2017) Ebru Aydin et al.   Cancer Immunology Research

Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles

(2017) Jingga Morry et al.   Redox Biology

Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells

(2017) Aida Rodriguez-Garcia et al.   Redox Biology

Green Tea Polyphenol Induces Changes in Cancer-Related Factors in an Animal Model of Bladder Cancer

(2017) Tomohiro Matsuo et al.   PLoS One

Activation of NADPH oxidases leads to DNA damage in esophageal cells

(2017) Vikas Bhardwaj et al.   Scientific Reports

Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation

(2016) Elaine Lai-Han Leung et al.   ANTIOXIDANTS & REDOX SIGNALING

Renal Carcinogenesis, Tumor Heterogeneity, and Reactive Oxygen Species: Tactics Evolved

(2016) Karthigayan Shanmugasundaram et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of NADPH oxidases in inducing a selective increase of oxidant stress and cyclin D1 and checkpoint 1 over-expression during progression to human gastric adenocarcinoma

(2016) Eduardo E. Montalvo-Javé et al.   EUROPEAN JOURNAL OF CANCER

Combination of carmustine and selenite effectively inhibits tumor growth by targeting androgen receptor, androgen receptor-variants, and Akt in preclinical models: New hope for patients with castration resistant prostate cancer

(2016) Vijayalakshmi Thamilselvan et al.   INTERNATIONAL JOURNAL OF CANCER

Coumestrol Inhibits Proliferation and Migration of Prostate Cancer Cells by Regulating AKT, ERK1/2, and JNK MAPK Cell Signaling Cascades

(2016) Whasun Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Guizhi Fuling Wan as a Novel Agent for Intravesical Treatment for Bladder Cancer in a Mouse Model

(2016) Chi-Chen Lu et al.   MOLECULAR MEDICINE

5-bromo-3-(3-hydroxyprop-1-ynyl)-2H-pyran-2-one induces apoptosis in T24 human bladder cancer cells through mitochondria-dependent signaling pathways

(2016) Guo-Qiang Yu et al.   Molecular Medicine Reports

Galangin inhibits cell invasion by suppressing the epithelial-mesenchymal transition and inducing apoptosis in renal cell carcinoma

(2016) JINGYI CAO et al.   Molecular Medicine Reports

Dual oxidase 1: A predictive tool for the prognosis of hepatocellular carcinoma patients

(2016) SHENGSEN CHEN et al.   ONCOLOGY REPORTS

Thymoquinone induces apoptosis through downregulation of c-FLIP and Bcl-2 in renal carcinoma Caki cells

(2016) Eun Jung Park et al.   ONCOLOGY REPORTS

Carnosic acid induces apoptosis through inactivation of Src/STAT3 signaling pathway in human renal carcinoma Caki cells

(2016) JI EUN PARK et al.   ONCOLOGY REPORTS

ABT-737, a Bcl-2 Selective Inhibitor, and Chloroquine Synergistically Kill Renal Cancer Cells

(2016) Pei Yin et al.   ONCOLOGY RESEARCH

Immunomodulatory proteins FIP-gts and chloroquine induce caspase-independent cell death via autophagy for resensitizing cisplatin-resistant urothelial cancer cells

(2016) I-Lun Hsin et al.   PHYTOMEDICINE

Increased Intracellular Reactive Oxygen Species Mediates the Anti-Cancer Effects of WZ35 via Activating Mitochondrial Apoptosis Pathway in Prostate Cancer Cells

(2016) Minxiao Chen et al.   PROSTATE

DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon

(2016) Ran Qi et al.   Gastroenterology Research and Practice

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

JS-K promotes apoptosis by inducing ROS production in human prostate cancer cells

(2016) Mingning Qiu et al.   Oncology Letters

Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways

(2016) Wei-Feng Zhong et al.   Oncology Letters

Prostate tumor-induced angiogenesis is blocked by exosomes derived from menstrual stem cells through the inhibition of reactive oxygen species

(2016) Francisca Alcayaga-Miranda et al.   Oncotarget

The combination of three molecular markers can be a valuable predictive tool for the prognosis of hepatocellular carcinoma patients

(2016) Sheng-Sen Chen et al.   Scientific Reports

Niclosamide suppresses renal cell carcinoma by inhibiting Wnt/β-catenin and inducing mitochondrial dysfunctions

(2016) Juan Zhao et al.   SpringerPlus

Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity

(2016) Gagan Deep et al.   Scientific Reports

Regulation of MMP-1 expression in response to hypoxia is dependent on the intracellular redox status of metastatic bladder cancer cells

(2015) Dong Hui Shin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Extracellular localization of catalase is associated with the transformed state of malignant cells

(2015) Britta Böhm et al.   BIOLOGICAL CHEMISTRY

Piperlongumine and its analogs down-regulate expression of c-Met in renal cell carcinoma

(2015) Konstantin Golovine et al.   CANCER BIOLOGY & THERAPY

Reactive Oxygen Species in Cancer: A Dance with the Devil

(2015) Paul T. Schumacker   CANCER CELL

Direct and indirect inactivation of tumor cell protective catalase by salicylic acid and anthocyanidins reactivates intercellular ROS signaling and allows for synergistic effects

(2015) Katrin Scheit et al.   CARCINOGENESIS

6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression

(2015) Min Ae Han et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System

(2015) D. I. Brown et al.   CIRCULATION RESEARCH

ROS signaling by NADPH oxidase 5 modulates the proliferation and survival of prostate carcinoma cells

(2015) Monika Höll et al.   MOLECULAR CARCINOGENESIS

A reactive oxygen species activation mechanism contributes to JS-K-induced apoptosis in human bladder cancer cells

(2015) Mingning Qiu et al.   Scientific Reports

Increasing the endogenous NO level causes catalase inactivation and reactivation of intercellular apoptosis signaling specifically in tumor cells

(2015) Georg Bauer   Redox Biology

Aristolochic acid-induced apoptosis and G2 cell cycle arrest depends on ROS generation and MAP kinases activation

(2014) Victor Romanov et al.   ARCHIVES OF TOXICOLOGY

NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2 

(2014) J. L. Gregg et al.   CANCER RESEARCH

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Src inhibition potentiates antitumoral effect of paclitaxel by blocking tumor-induced angiogenesis

(2014) Simona Delle Monache et al.   EXPERIMENTAL CELL RESEARCH

The Fas Death Signaling Pathway Connecting Reactive Oxygen Species Generation and FLICE Inhibitory Protein Down-Regulation

(2014) L. Wang et al.   JOURNAL OF IMMUNOLOGY

Pathological significance and prognostic role of microvessel density, evaluated using CD31, CD34, and CD105 in prostate cancer patients after radical prostatectomy with neoadjuvant therapy

(2014) Yasuyoshi Miyata et al.   PROSTATE

Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species—Studies in White Blood Cells and in Animal Models

(2013) Swenja Kröller-Schön et al.   ANTIOXIDANTS & REDOX SIGNALING

Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody

(2013) Smitha Antony et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody

(2013) YONGHZONG WU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells

(2013) Sudjit Luanpitpong et al.   MOLECULAR BIOLOGY OF THE CELL

Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a

(2013) WEI LI et al.   ONCOLOGY REPORTS

The role of IL-6 in the radiation response of prostate cancer

(2013) Chun-Te Wu et al.   Radiation Oncology

Biomarkers of Oxidative Stress and Risk of Developing Colorectal Cancer: A Cohort-nested Case-Control Study in the European Prospective Investigation Into Cancer and Nutrition

(2012) A. M. Leufkens et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

NADPH Oxidases as Regulators of Tumor Angiogenesis: Current and Emerging Concepts

(2012) Sanja Coso et al.   ANTIOXIDANTS & REDOX SIGNALING

The antioxidant paradox: less paradoxical now?

(2012) Barry Halliwell   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals

(2012) K. Shimada et al.   CLINICAL CANCER RESEARCH

Redox regulation of cancer cell migration and invasion

(2012) Lalchhandami Tochhawng et al.   MITOCHONDRION

Effect of dual inhibition of apoptosis and autophagy in prostate cancer

(2012) Ahamed Saleem et al.   PROSTATE

Adiponectin inhibits oxidative stress in human prostate carcinoma cells

(2012) J-P Lu et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells

(2011) W.-C. Huang et al.   MOLECULAR CANCER RESEARCH

NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair

(2011) F. Jiang et al.   PHARMACOLOGICAL REVIEWS

Cadmium Increases HIF-1 and VEGF Expression through ROS, ERK, and AKT Signaling Pathways and Induces Malignant Transformation of Human Bronchial Epithelial Cells

(2011) Yi Jing et al.   TOXICOLOGICAL SCIENCES

Angiotensin II Type 1 Receptor Expression and Microvessel Density in Human Bladder Cancer

(2011) Suguru Shirotake et al.   UROLOGY

ROS generation via NOX4 and its utility in the cytological diagnosis of urothelial carcinoma of the urinary bladder

(2011) Keiji Shimada et al.   BMC Urology

Multiple protective functions of catalase against intercellular apoptosis-inducing ROS signaling of human tumor cells

(2010) Sonja Heinzelmann et al.   BIOLOGICAL CHEMISTRY

BLT2 promotes the invasion and metastasis of aggressive bladder cancer cells through a reactive oxygen species-linked pathway

(2010) Eun-Young Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins

(2010) Lee   INTERNATIONAL JOURNAL OF ONCOLOGY

Oxidative Modification of Nuclear Mitogen-activated Protein Kinase Phosphatase 1 Is Involved in Transforming Growth Factor β1-induced Expression of Plasminogen Activator Inhibitor 1 in Fibroblasts

(2010) Rui-Ming Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential induction of reactive oxygen species through Erk1/2 and Nox-1 by FK228 for selective apoptosis of oncogenic H-Ras-expressing human urinary bladder cancer J82 cells

(2010) Shambhunath Choudhary et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cis-dichlorodiammineplatinum Upregulates Angiotensin II Type 1 Receptors through Reactive Oxygen Species Generation and Enhances VEGF Production in Bladder Cancer

(2010) N. Tanaka et al.   MOLECULAR CANCER THERAPEUTICS

A Novel Human AlkB Homologue, ALKBH8, Contributes to Human Bladder Cancer Progression

(2009) K. Shimada et al.   CANCER RESEARCH

Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues

(2009) Agnes Juhasz et al.   FREE RADICAL RESEARCH

Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cells

(2009) Kyung Lee et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase

(2009) J P Lu et al.   PROSTATE CANCER AND PROSTATIC DISEASES

A summary measure of pro- and anti-oxidant exposures and risk of incident, sporadic, colorectal adenomas

(2008) Michael Goodman et al.   CANCER CAUSES & CONTROL

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

(2008) Masuko Ushio-Fukai et al.   CANCER LETTERS

Oxidative Stress Is Inherent in Prostate Cancer Cells and Is Required for Aggressive Phenotype

(2008) B. Kumar et al.   CANCER RESEARCH

Silencing of DUOX NADPH Oxidases by Promoter Hypermethylation in Lung Cancer

(2008) S. Luxen et al.   CANCER RESEARCH

Mitochondrial complex III regulates hypoxic activation of HIF

(2008) T Klimova et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of oxidative stress-induced carcinogenesis: From epidemiology to oxygenomics

(2008) Shinya Toyokuni   IUBMB LIFE